Phenolic components and antioxidant activity of Fernblock®, an aqueous extract of the aerial parts of the fern Polypodium leucotomos

Methods and Findings in Experimental and Clinical Pharmacology

Volumn 28, Issue 3, 2006, Pages 157-160

  Garcia F ^a   Pivel, J P ^a   Guerrero, A ^a   Brieva, A ^a   Martinez Alcazar M P ^b   Caamano Somoza M ^b   Gonzalez S ^c  

^a Industrial Farmacéutica Cantabria ^*  (Spain)

^b UNIVERSIDAD SAN PABLO CEU   (Spain)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Antioxidant; FRAP; HPLC Electrochemical detection; HPLC Mass spectrum; Phenolics; Polypodium

Indexed keywords

4 HYDROXYBENZOIC ACID; 4 HYDROXYCINNAMOYLQUINIC ACID; CAFFEIC ACID; CHLOROGENIC ACID; FERNBLOCK; FERULIC ACID; PARA COUMARIC ACID; PHENOL DERIVATIVE; POLYPODIUM LEUCOTOMOS EXTRACT; SCAVENGER; UNCLASSIFIED DRUG; VANILLIC ACID;

ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG FORMULATION; DRUG IDENTIFICATION; ELECTROCHEMICAL DETECTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; ULTRAVIOLET SPECTROSCOPY;

ANTIOXIDANTS; CAFFEIC ACIDS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COUMARIC ACIDS; ELECTROCHEMISTRY; FERRIC COMPOUNDS; MASS SPECTROMETRY; OXIDATION-REDUCTION; PARABENS; PHENOLS; PLANT COMPONENTS, AERIAL; PLANT EXTRACTS; POLYPODIUM; VANILLIC ACID;

EID: 33745313356     PISSN: 03790355     EISSN: None     Source Type: Journal    
DOI: 10.1358/mf.2006.28.3.985227     Document Type: Article

References (29)

1. Hassler, M., Brian, S. Checklist of ferns and fern allies 2001. Available at www.caverock.net.nz/~bj/fern/phlebodium.htm
2. Stolze, R. Ferns and fern allies of Guatemala. Part II. Polypodiace. Fieldiana-Botany Vol. 6: 374.
3. Ruiz, H. Disertaciones sobre la raíz de la Rathania, de la Calaguala y de la China y acerca de la yerba llamada Canchalagua. Biblioteca de clásicos de la Farmacia española. Coedición Fundación Ciencias de la Salud, Sociedad Estatal Quinto Centenario y Real Jardín Botánico (CSIC): Madrid, 1992.
4. House, R.P., Lagos, S., Ochoa, L., Torres, C., Mejia, T., Rivas, M. Plantas Medicinales Comunes de Honduras. UNAH-CIMN-H CID/CIIR.GTZ: Honduras 1994, 369.
5. Lucca, D.M. Flora Medicinal Boliviana: Diccionario Enciclopédico. Editorial Los Amigos del Libro: La Paz, Bolivia 1992, 321.
6. Horvath, A., Alvarado, F., Szocs, J., de Alvardo, Z.N., Padilla, G. Metabolic effects of calagualine, an antitumoral saponine of Polypodium leucotomos. Nature 1967, 214: 1256.
7. Padilla, H.C., Lainez, H., Pacheco, J.A. A new agent (hydrophilic fraction of Polypodium leucotomos) for management of psoriasis. Int J Dermatol 1974, 13: 276.
8. Vasange-Tuominen, M., Perera-Ivarsson, P., Shen, J., Bohlin, L., Rolfsen, W. The fern Polypodium decumanum, used in the treatment of psoriasis, and its fatty acid constituents as inhibitors of leukotriene B4 formation. Prostaglandins Leukot Essent Fatty Acids 1994, 50(5): 279.
9. Jimenez, D., Naranjo, R., Doblare, E., Munoz, C., Vargas, J.F. Anapsos, an anti-psoriatic drug, in atopic dermatitis. Allergol Immunopathol (Madr) 1987, 15: 185.
10. Mohammad, A. Vitiligo repigmentation with Anapsos (Polypodium leucotomos). Int J Dermatol 1989, 28: 479.
11. Gonzalez, S., Pathak, M.A. Inhibition of ultraviolet-induced formation of reactive oxygen species, lipid peroxidation, erythema and skin photosensitization by Polypodium leucotomos. Photodermatol Photoimmunol Photomed 1996, 12: 45.
12. Gomes, A.J., Lunardi, C.N., Gonzalez, S., Tedesco, A.C. The antioxidant action of Polypodium leucotomos extract and kojic acid: reactions with reactive oxygen species. Braz J Med Biol Res 2001, 34: 1487.
13. Gonzalez, S., Pathak, M.A., Cuevas, J., Villarrubia, V., Fitzpatrick, T.B. Topical or oral administration with an extract of Polypodium leucotomos prevents acute sunburn and psoralen-induced phototoxic reactions as well as depletion of Langerhans cells in human skin. Photodermatol Photoimmunol Photomed 1997, 13: 50.
14. Middelkamp-Hup, M.A., Pathak, M.A., Parrado, C., Goukassian, D., Rius-Diaz, F., Mihm, M.C., Fitzpatrick, T.B., Gonzalez, S. Oral Polypodium leucotomos extract decreases ultraviolet-induced damage of human skin. J Am Acad Dermatol 2004, 51(6): 910.
15. Vasange, M., Liu, B., Welch, C.J., Rolfsen, W., Bohlin, L. The flavonoid constituents of two Polypodium species (Calaguala) and their effect on the elastase release in human neutrophils. Planta Med 1997, 63(6): 511.
16. Duke, J.A. Chemicals and their biological Activities in: Polypodium aureum L. (Polypodiaceae). Calaguala Phytochemical Database, USDA-ARS-NGRL, Beltsville Agricultural Research Center: Beltsville, Maryland. Available at www.ars-grin.gov/cgi-bin/duke.
17. Manna, S.K., Bueso-Ramos, C., Alvarado, F., Aggarwal, B.B. Calagualine inhibits nuclear transcription factors-kappaB activated by various inflammatory and tumor promoting agents. Cancer Lett 2003, 190(2): 171.
18. Singlenton, V.L., Orthofer, R., Lamuela-Raventos, R.M. Analysis of total phenols and other oxidation substrates by means of Folin-Ciocalteau reagent. Methods Enzymol 1999, 299: 152.
19. Aaby, K., Hvattum, E., Skrede, G. Analysis of flavonoids and other phenolic compounds using high-performance liquid chromatography with coulometric array detection: Relationship to antioxidant activity. J Agric Food Chem 2004, 52(15): 4595.
20. Fang, N., Yu, S., Prior, R.L. LC/MS/MS characterization of phenolic constituents in dried plums. J Agric Food Chem 2002, 50(12): 3579.
21. n identification of chlorogenic acids. J Agric Food Chem 2003, 51(10): 2900.
22. Lazarowych, N., Pekos, P. Use of fingerprint and marker compounds for identification and standardization of botanical drugs. Strategies for applying pharmaceutical HPLC analysis to herbal products. Drug Inf J 1998, 32: 497.
23. Allen, S.D., Almond, M.J., Bruneel, J.L., Gilbert, A., Hollins, P., Mascetti, J. The photodimerisation of trans-cinnamic acid and its derivatives: A study by vibrational microspectroscopy. Spectrochim Acta A 2000, 56(12): 2423.
24. Cockell, C.H., Knowland, J. Ultraviolet radiation screening compounds. Biol Rev 1999, 74: 311.
25. Buettner, G.R., Schafer, F.Q. Free radicals, oxidants and antioxidants. Teratology 2000, 62: 234.
26. Capote, R., Alonso-Lebrero, J.L., García, F., Brieva, A., Pivel, J.P., González, S. Polypodium leucotomos extract inhibits transurocanic acid photoisomerization and photodecomposition. J Photochem Photobiol B 2006, 82: 173-9.
27. Gombau, L., García, F., Lahoz, A. et al. Polypodium leucotomos extract: Antioxidant activity and disposition. Toxicology in vitro. 2006, 20(4): 464.
28. Bentley, R. The shikimic pathway-A metabolic tree with many branches. Crit Rev Biochem Mol 1990, 25(5): 307.
29. Heller, W. Topics in the biosynthesis of plant phenols. Acta Horticulturae 1994, 381: 46.