Development of an ultra-fast single-photon counting imager for single-molecule imaging

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

Volumn 6092, Issue , 2006, Pages

  Ohnuki, Tohru ^a   Michalet, Xavier ^a   Tripathi, Arun ^a   Weiss, Shimon ^a   Arisaka, Katsushi ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

CMOS Camera; GaAsP Photocathode; Image Intensifier; MCP; Photon Counting; Single Molecule Imaging

Indexed keywords

CMOS CAMERAS; GAASP PHOTOCATHODES; MCP; PHOTON COUNTING; SINGLE-MOLECULE IMAGING;

ARRAYS; CMOS INTEGRATED CIRCUITS; DATA PROCESSING; FIELD PROGRAMMABLE GATE ARRAYS; FLUORESCENCE; IMAGE INTENSIFIERS (ELECTRON TUBE); IMAGING TECHNIQUES; MOLECULES; PHOTOCATHODES; PHOTONS; QUANTUM EFFICIENCY; REAL TIME SYSTEMS; SEMICONDUCTING GALLIUM COMPOUNDS; SPECTROSCOPIC ANALYSIS;

IMAGE SENSORS;

EID: 33745306909     PISSN: 16057422     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1117/12.658191     Document Type: Conference Paper

References (17)

1. S. Weiss, "Fluorescence Spectroscopy of Single Biomolecules", Science 283, 1676 - 1683 (1999).
2. S. Weiss, "Measuring Conformational Dynamics of Biomolecules by Single Molecule Fluorescence Spectroscopy", Nature Structural Biology 7, 724-729 (2000).
3. M. Dahan, T. Laurence, F. Pinaud, D. S. Chemla, A. P. Alivisatos, M. Sauer, S. Weiss. "Time-gated biological imaging by use of colloidal quantum dots", Optics Letters 26 (11): 825-827 (2001)
4. Michalet, X., Lacoste, T. D., Weiss. S., "Ultrahigh-Resolution Colocalization of Spectrally Separable Point-like Fluorescent Probes", Methods 25: 87-102 (2001)
5. Michalet, X., Weiss. S., "Single-molecule Spectroscopy and microscopy", Comptes rendus Physique 2 (4): 619-644 (2002)
6. Michalet, X., Pinaud, F. F., Bentolila, L. A., Tsay, J. M., Doose, S., Li, J. J., Sundaresan, G., Wu, A. M., Gambhir, S. S., Weiss. "Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics", S. Science 307 538 -544 (2005)
7. K. Arisaka, "New Trends in Vacuum-Based Photon Detectors", Nucl. Instrum. Meth. A442, 80 (2000),
8. 2nd International Conference on New Developments in Photodetection (Beaune 99), Beaune, France, 21-25 Jun 1999
9. K. Arisaka, "Summary Talk" at 4th International Conference on New Developments in Photodetection (Beaune 05), Beaune, France, 19-24 Jun 2005, unpublished.
10. Hübner, C. G.; Krylov, V.; Renn, A.; Nyffeler, P.; Wild, U. P. In Single Molecule Spectroscopy; Rigler, R., Orrit, M., Basche, T., Eds.; Springer Verlag: Stockholm, 2001.
11. Kelly, L. A.; Trunk, J. G.; Polewski, K.; Sutherland, J. C. Rev. Sci. Instr. 1995, 66, 1496-1498.
12. Kelly, L. A.; Trunk, J. G.; Sutherland, J. C. Rev. Sci. Instr. 1997, 68, 2279-2286.
13. Emiliani, V.; Sanvitto, D.; Tramier, M.; Piolot, T.; Petrasek, Z.; Kemnitz, K.; Durieux, C.; Coppey-Moisan, M. Appl. Phys. Lett. 2003, 83, 2471-2473.
14. Lampton, M.; Paresce, F. Rev. Sci. Instr. 1974, 45, 1098-1105.
15. Lampton, M.; Malina, R. F. Rev. Sci. Instr. 1976, 47, 1360-1362.
16. Siegmund, O. H. W.; Gummin, M. A.; Stock, J.; Marsh, D.; Raffanti, R.; Sasseen, T.; Tom, J.; Welsh, B.; Gaines, G.; Jelinsky, P.; Hull, J. Proc. SPIE 1994, 2280, 89-100.
17. Michalet, X.; Siegmund, O. H. W.; Vallerga, J. V.; Jelinsky, P. N.; Millaud, J. E.; Weiss, S. Nucl. Instrum. & Meth. A 2006, submitted.