Age-associated changes in oxidative damage and the activity of antioxidant enzymes in rats with inherited overgeneration of free radicals

Journal of Cellular and Molecular Medicine

Volumn 10, Issue 1, 2006, Pages 206-215

  Sinitsyna, Olga ^a   Krysanova, Zhanna ^a   Ishchenko, A ^b   Dikalova, Anna E ^a   Stolyarov, S ^c   Kolosova, Nataliya ^a   Vasunina, Elena ^a   Nevinsky, Georgy ^b  

^a INSTITUTE OF CYTOLOGY AND GENETICS   (Russian Federation)

^b INSTITUTE OF CHEMICAL BIOLOGY AND FUNDAMENTAL MEDICINE   (Russian Federation)

^c KOL TSOV INSTITUTE OF DEVELOPMENTAL BIOLOGY   (Russian Federation)

Author keywords

Antioxidant enzymes; Nuclear and mitochondrial extracts; OXYS rats aging; Protein carbonyl groups

Indexed keywords

RATTUS NORVEGICUS; VACCINIUM MYRTILLUS;

ANTIOXIDANT; CATALASE; FREE RADICAL; GLUTATHIONE PEROXIDASE; PLANT MEDICINAL PRODUCT; SUPEROXIDE DISMUTASE;

AGING; ANIMAL; ARTICLE; COMPARATIVE STUDY; CYTOSOL; DIET SUPPLEMENTATION; DNA DAMAGE; ENZYMOLOGY; LIVER CELL; LIVER MITOCHONDRION; METABOLISM; OXIDATIVE STRESS; RAT; RAT STRAIN; WISTAR RAT;

AGING; ANIMALS; ANTIOXIDANTS; CATALASE; CYTOSOL; DIETARY SUPPLEMENTS; DNA DAMAGE; FREE RADICALS; GLUTATHIONE PEROXIDASE; HEPATOCYTES; MITOCHONDRIA, LIVER; OXIDATIVE STRESS; PLANT PREPARATIONS; RATS; RATS, INBRED STRAINS; RATS, WISTAR; SUPEROXIDE DISMUTASE;

EID: 33745300235     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2006.tb00301.x     Document Type: Article

References (31)

1. Harman D. Aging: a theory based on free radical and radiation chemistry. J Gerontol. 1956; 11: 298-300.
2. Cathcart R, Schwiers RL, Saul E, Ames BN. Thymine glycol and thymidine glycol in human and rat urine: a possible assay for oxidative DNA damage. Proc Natl Acad Sci USA 1984; 81: 5633-7.
3. Richter C, Park JW, Ames BN. Normal oxidative damage to mitochondrial and nuclear DNA is extensive. Proc Natl Acad Sci USA. 1998; 85: 6465-7.
4. Adelman R, Saul RL, Ames BN. Oxidative damage to DNA: relation to species metabolic rate and life span. Proc Natl Acad Sci USA 1988; 85: 2706-8.
5. Cutler RG. Antioxidants and aging. Am J Clin Nutr. 1991; 53: 373S-9S.
6. Ames BN. Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases. Science 1983; 221: 1256-64.
7. Beckman KB, Ames BN. The free radical theory of aging matures. Physiol Rev. 1998; 78: 547-81.
8. Allen RG. Free radicals in aging, Boca Raton, FL: CPC Press, 1993, pp. 12-23.
9. Feuers RJ, Weindruch R, Hart RW. Caloric restriction, aging, and antioxidant enzymes. Mutat Res. 1993; 295: 191-200.
10. Gutler RG. Human longevity and aging: possible role of reactive oxygen species. Ann NY Acad Sci. 1991; 621: 1-28.
11. Haycock JW, Jones P, Harris JB, Mantle D. Differential susceptibility of human skeletal muscle proteins to free radical induced oxidative damage: a histochemical, immunocytochemical and electron microscopical study in vitro. Acta Neuropathol. 1996; 92: 331-40.
12. Halliwell B, Dizgaroglu M. Free radicals, antioxidants, and human disease: curiosity, cause, or consequence? Lancet 1994; 344: 721-4.
13. Salganik RI, Solovyova NA, Dikalov SI, Grishaeva ON, Semenova LA, Popovsky AV. Inherited enhancement of hydroxyl radical generation and lipid peroxidation in the S strain rats results in DNA rearrangements degenerative diseases and premature aging. Biochem Biophys Res Commun. 1994; 199: 726-33.
14. Inbred Strains of Rats: OXYS, Rat Genome 1996; 2: 52-4.
15. Ceballos-Picot I, Nicole A, Clement M, Bourre JM, Sinet PM. Age-related changes in antioxidant enzymes and lipid peroxidation in brains of control and transgenic mice overexpressing copper-zinc superoxide dismutase. Mutat Res. 1992; 275: 281-93.
16. Tian L, Cai Q, Wei H. Alterations of antioxidant enzymes and oxidative damage to macromolecules in different organs of rats during aging. Free Radic Biol Med. 1998; 24: 1477-84.
17. Yamamura H, Hayakawa M, Iimura Y, Yamamura H, Hayakawa M, Iimura Y. Application of sucrose-gradient centrifugation for selective isolation of Nocardia spp. from soil. J Appl Microbiol. 2003; 95: 677-85.
18. Lowry OH, Rosenbrough NJ, Farr AL, Randall RG. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951; 193: 265-75.
19. Reznick AZ, Packer L. Oxidative damage to proteins: spectrophotometric method for carbonyl assay. Methods Enzymol. 1994; 233: 357-63.
20. Beachamp C, Fridovich I. Superoxide dismutase: improved assays and an assay applicable to acrylamide gels. Analyt Biochem. 1971; 44: 276-390.
21. Flohe L, Otting F. Superoxide Dismutase Assay. Methods Enzymol. 1984; 105: 93-104.
22. Aebi H. Catalase in vitro. Methods Enzymol. 1984; 105: 121-30.
23. Flohe L, Gunzler WA. Assays of glutathione peroxidase. Methods Enzymol. 1984; 105: 114-21.
24. Cao G, Shukitt-Hale B, Bickford PC, Joseph JA, McEwen J, Prior RL. Hyperoxia-induced changes in antioxidant capacity and the effect of dietary antioxidants, J Appl Physiol. 1999; 86: 1817-22.
25. Ramirez-Tortosa C, Andersen QM, Gardner PT, Morrice PC, Wood SG, Duthie SJ, Collins AR, Duthie GG. Anthocyanin-rich extract decreases indices of lipid peroxidation and DNA damage in vitamin E-depleted rats. Free Radic Biol Med. 2001; 31: 1033-7.
26. Hayakawa M, Torii K, Sugiyama S, Tanaja M, Ozava T. Age-associated accumilation of 8-hydroxydeoxyguanosine in miticondrial DNA of human diaphragm. Biochem Biophys Res Commun. 1991; 178: 1023-9.
27. Bhuyan KC, Bhuyan DK, Podos SM. Lipid peroxidation in cataracts of the human. Life Sci. 1986; 38: 1463-71.
28. Scharf J, Dorvarat A. Superoxide dismutase molecules in human cataractous lenses. Opthal Res. 1986; 18: 332-7.
29. Shigenaga MK, Hagen T, Ames BN. Oxidative damage and mitochondrial decay in aging. Proc Natl Acad Sci USA. 91: 10771-8, 1994
30. Kolosova NG, Lebedev PA, Aidagulova SV, Morozkova TS. OXYS Rats as a model of senile cataract. Bull Exp Biol Med. 2003; 136: 415-9.
31. Ishchenko A, Sinitsyna O, Krysanova Zh, Vasyunina E, Saparbaev M, Sidorkina O, Nevinsky G. Age-dependent increase of 8-oxoguanine-, hypoxanthine-, and uracil DNA glycosylase activities of liver extracts from OXYS rats with inherited overgeneration of free radicals and Wistar rats. Med Sci Monit. 2003; 9: BR16-24.