Physiological and biophysical factors that influence Alzheimer's disease amyloid plaque targeting of native and putrescine modified human amyloid β40

Journal of Pharmacology and Experimental Therapeutics

Volumn 318, Issue 1, 2006, Pages 17-25

  Kandimalla, Karunya K ^a,b   Curran, Geoffry L ^a   Holasek, Silvina S ^a   Gilles, Emily J ^a   Wengenack, Thomas M ^a   Ramirez Alvarado, Marina ^a   Poduslo, Joseph F ^a,c  

^a MAYO GRADUATE SCHOOL   (United States)

^b FLORIDA A AND M UNIVERSITY   (United States)

^c Mayo Clinic   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DINITROPHENOL; AMYLOID BETA PROTEIN[1-40]; FLUORESCEIN; IODINE 125; OUABAIN; PUTRESCINE; THIOFLAVINE;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BETA SHEET; BIOPHYSICS; BLOOD BRAIN BARRIER; BRAIN CELL; BRAIN SLICE; CELL METABOLISM; CIRCULAR DICHROISM; COMPLEX FORMATION; CONTROLLED STUDY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG METABOLISM; DRUG TARGETING; DRUG UPTAKE; EFFUSION; FIBER; IN VITRO STUDY; MAXIMUM ALLOWABLE CONCENTRATION; MOUSE; NONHUMAN; PERMEABILITY BARRIER; PRIORITY JOURNAL; SENILE PLAQUE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; BRAIN; HUMANS; MICE; PEPTIDE FRAGMENTS; PUTRESCINE; SENILE PLAQUES;

EID: 33745269291     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.105.095711     Document Type: Article

References (24)

1. Agdeppa ED, Kepe V, Liu J, Flores-Torres S, Satyamurthy N, Petric A, Cole GM, Small GW, Huang SC, and Barrio JR (2001) Binding characteristics of radiofluorinated 6-dialkylamino-2-naphthylethylidene derivatives as positron emission tomography imaging probes for beta-amyloid plaques in Alzheimer's disease. J Neurosci Methods 21:RC189.
2. Bacskai BJ, Kajdasz ST, Christie RH, Carter C, Games D, Seubert P, Schenk D, and Hyman BT (2001) Imaging of amyloid-beta deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy. Nat Neurosci 7:369-372.
3. Dellian M, Yuan F, Trubetskoy VS, Torchilin VP, and Jain RK (2000) Vascular permeability in a human tumour xenograft: molecular charge dependence. Br J Cancer 82:1513-1518.
4. Gredell JA, Turnquist PA, Maciver MB, and Pearce RA (2004) Determination of diffusion and partition coefficients of propofol in rat brain tissue: implications for studies of drug action in vitro. Br J Anaesth 93:810-817.
5. 125I-amyloid beta protein 40 in wild-type and Alzheimer's disease transgenic mice (APP,PS1) and its implications for amyloid plaque formation. J Pharmacol Exp Ther 313:1370-1378
6. Klunk WE, Engler H, Nordberg A, Wang Y, Blomqvist G, Holt DP, Bergstrom M, Savitcheva I, Huang GF, Estrada S, et al. (2004) Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B. Ann Neurol 55:306-319.
7. Levine H 3rd (1993) Thioflavin-T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution. Protein Sci 2:404-410.
8. Mackic JB, Bading J, Ghiso J, Walker L, Wisniewski T, Frangione B, and Zlokovic BV (2002) Circulating amyloid-beta peptide crosses the blood-brain barrier in aged monkeys and contributes to Alzheimer's disease lesions. Vas Pharmacol 38:303-313.
9. Maness LM, Banks WA, Podlisny MB, Selkoe DJ, and Kastin AJ (1994) Passage of human amyloid beta-protein 1-40 across the murine blood-brain barrier. Life Sci 55:1643-1650.
10. Newman GC, Hospod FE, and Patlak CS (1990) Kinetic model of 2-deoxyglucose metabolism using brain slices. J Chem Doc 10:510-526.
11. +, pH and glutamate on 45Ca kinetics in hippocampal brain slices. J Neurosci Nurs 59:111-120.
12. Patlak CS, Hospod FE, Trowbridge SD, and Newman GC (1998) Diffusion of radiotracers in normal and ischemic brain slices. J Cereb Blood Flow Metab 18:776-802.
13. Poduslo JF (1993) Albumin and the blood-nerve barrier, in Peripheral Neuropathy (Dyck PJ, Thomas PK, Low PA, Griffin JW, and Poduslo JF eds) vol 1, 3rd ed, pp 446-452, W. B. Saunders Company, Philadelphia, PA.
14. Poduslo JF and Curran GL (1996a) Increased permeability of superoxide dismutase at the blood-nerve and blood-brain barriers with retained enzymatic activity after covalent modification with the naturally occurring polyamine, putrescine. J Neurochem 67:734-741.
15. Poduslo JF and Curran GL (1996b) Polyamine modification increases the permeability of proteins at the blood-nerve and blood-brain barriers. J Neurochem 66:1599-1609.
16. Poduslo JF, Curran GL, Haggard JJ, Biere AL, and Selkoe DJ (1997) Permeability and residual plasma volume of human, Dutch variant and rat amyloid beta-protein 1-40 at the blood-brain barrier. Neurobiol Dis 4:27-34.
17. Poduslo JF, Curran GL, Peterson JA, McCormick DJ, Fauq AH, Khan MA, and Wengenack TM (2004) Design and chemical synthesis of a magnetic resonance contrast agent with enhanced in vitro binding, high blood-brain barrier permeability and in vivo targeting to Alzheimer's disease amyloid plaques. Biochemistry 43:6064-6075.
18. Poduslo JF, Curran GL, Sanyal B, and Selkoe DJ (1999) Receptor-mediated transport of human amyloid beta-protein 1-40 and 1-42 at the blood-brain barrier. Neurobiol Dis 6:190-199.
19. Poduslo JF, Curran GL, Wengenack TM, Malester B, and Duff K (2001) Permeability of proteins at the blood-brain barrier in the normal adult mouse and double transgenic mouse model of Alzheimer's disease. Neurobiol Dis 8:555-567.
20. Poduslo JF, Wengenack TM, Curran GL, Wisniewski T, Sigurdsson EM, Macura SI, Borowski BJ, and Jack CR Jr (2002) Molecular targeting of Alzheimer's amyloid plaques for contrast-enhanced magnetic resonance imaging. Neurobiol Dis 11:315-329.
21. Skovronsky DM, Zhang B, Kung MP, Kung HF, Trojanowski JQ, and Lee VM (2000) In vivo detection of amyloid plaques in a mouse model of Alzheimer's disease. Proc Natl Acad Sci USA 97:7609-7614.
22. Wengenack TM, Curran GL, and Poduslo JF (2000a) Targeting Alzheimer amyloid plaques in vivo. Nat Biotechnol 18:868-872.
23. Wengenack TM, Whelan S, Curran GL, Duff KE, and Poduslo JF (2000b) Quantitative histological analysis of amyloid deposition in Alzheimer's double transgenic mouse brain. Neuroscience 101:939-944.
24. Zlokovic BV, Ghiso J, Mackic JB, McComb JG, Weiss MH, and Frangione B (1993) Blood-brain barrier transport of circulating Alzheimer's amyloid beta. Biochem Biophys Res Commun 197:1034-1040.