Therapeutic window for cycloheximide treatment after hypoxic-ischemic brain injury in neonatal rats

Journal of Korean Medical Science

Volumn 21, Issue 3, 2006, Pages 490-494

  Won, Soon Park ^a   Dong, Kyung Sung ^b   Kang, Saem ^b   Soo, Hyun Koo ^a   Yu, Jin Kim ^a   Jang, Hoon Lee ^a   Yun, Sil Chang ^a   Lee, Munhyang ^a  

^a Sungkyunkwan University School of Medicine   (South Korea)

^b Samsung Medical Center   (South Korea)

Author keywords

Animals, Newborn; Apoptosis; Cycloheximide; Hypoxia Ischemia, Brain

Indexed keywords

EID: 33745246322     PISSN: 10118934     EISSN: 15986357     Source Type: Journal    
DOI: 10.3346/jkms.2006.21.3.490     Document Type: Article

References (28)

1. Delivoria-Papadopoulos M, Mishra OP. Mechanisms of cerebral injury in perinatal asphyxia and strategies for prevention. J Pediatr 1998; 132: S30-4.
2. Vannucci RC, Perlman JM. Interventions for perinatal hypoxic-ischemic encephalopathy. Pediatrics 1997; 100: 1004-14.
3. Robertson NJ, Edwards AD. Recent advances in developing neuroprotective strategies for perinatal asphyxia. Curr Opin Pediatr 1998; 10: 575-80.
4. Chang YS, Park WS, Lee M, Kim KS, Shin SM, Choi JH. Near infrared spectroscopic monitoring of secondary cerebral energy failure after transient global hypoxia-ischemia in the newborn piglet. Neurol Res 1998; 21: 216-24.
5. Cheng Y, Deshmukh M, D'Costa A, Demaro JA, Gidday JM, Shah A, Sun Y, Jacuin MF, Johnson EM, Holtzman DM. Caspase inhibitor affords neuroprotection with delayed administration in a rat model of neonatal hypoxic-ischemic brain injury. J Clin Invest 1998; 101: 1992-9.
6. Kirino T. Delayed neuronal death in the gerbil hippocampus following ischemia. Brain Res 1997; 239: 57-69.
7. Whitelaw A, Thorensen M. Clinical trials after perinatal asphyxia. Curr Opin Pediatr 2002; 14: 664-8.
8. Groenendaal F, de Vries LS. Selection of babies for intervention after birth asphyxia. Semin Neonatol 2000; 5: 17-32.
9. Fellman V, Raivio KO. Reperfusion injury as the mechanism of brain damage after perinatal asphyxia. Pediatr Res 1997; 41: 599-606.
10. Linnik MD, Zobrist RH, Hatfield MD. Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats. Stroke 1993; 24: 2002-9.
11. Renovoize C, Biola A, Pallardy M, Breard J. Apoptosis: identification of dying cells. Cell Biol Toxicol 1998; 14: 111-20.
12. Taylor DL, Edwards AD, Mehmet H. Oxidative metabolism, apoptosis and perinatal brain injury. Brain Pathol 1999; 9: 93-117.
13. Martin LJ, Al-Abdulla NA, Branbrink AM, Kirsch JR, Sieber FE, Portera-Cailliau C. Neurodegeneration in excitotoxicity, global cerebral ischemia, and target deprivation: a perspective on the contributions of apoptosis and necrosis. Brain Res Bull 1998; 46: 281-309.
14. Johnson EM Jr, Deckwerth TL. Molecular mechanisms of developmental neuronal death. Annu Rev Neurosci 1993; 16: 31-46.
15. Snider BJ, Du C, Wei L, Choi DW. Cycloheximide reduces infarct volume when administered up to 6 h after mild focal ischemia in rats. Brain Res 2001; 917: 147-57.
16. Zhu C, Wang X, Xu F, Bahr BA, Shibata M, Uchiyama Y, Hagberg H, Blomgren K. The influence of age on apoptotic and other mechanisms of cell death after cerebral hypoxia-ischemia. Cell Death Differ 2005; 12: 162-76.
17. Geddes R, Vannucci RC, Vannucci SJ. Delayed cerebral atrophy following moderate hypoxia-ischemia in the immature rat. Dev Neurosci 2001; 23: 180-5.
18. Park WS, Sung DK, Kang S, Koo SH, Kim YJ, Lee JH, Chang YS, Lee M. Neuroprotective effect of cycloheximide on hypoxic-ischemic brain injury in neonatal rats. J Korean Med Sci 2006; 21: 337-41.
19. Kidwell CS, Liebeskind DS, Starkman S, Saver JL. Trends in acute ischemic stroke trials through the 20th century. Stroke 2001; 32: 1349-59.
20. Pavlik A, Teisinger J. Effect of cycloheximide administered to rats in early postnatal life: prolonged of DNA synthesis in the developing brain. Brain Res 1980; 192: 531-41.
21. Hwang JH, Sung DK, Choi CW, Kang S, Chang YS, Park WS, Lee M. Single cell dissociation methods for flow cytometric analysis hypoxia-ischemia injured newborn rat pup brain. Korean J Pediatr 2005; 48: 545-50.
22. Swanson RA, Morton MT, Tsao-Wu G, Savalos RA, Davidson Sharp FR. A semiautomated method for measuring brain infarct volume. J Cereb Blood Flow Metab 1990; 10: 290-3.
23. Furukawa K, Estus S, Fu W, Mark RJ, Mattson MP. Neuroprotective action of cycloheximide involves induction of Bcl-2 and antioxidant pathways. J Cell Biol 1997; 136: 1137-49.
24. Nam MJ, Thore C, Busija D. Rapid induction of prostaglandin synthesis in piglet astroglial cells by interleukin 1 . Brain Res Bull 1995; 36: 215-8.
25. Ratan RR, Murphy TH, Baraban JM. Macromolecular synthesis inhibitors prevent oxidative stress-induced apoptosis in embryonic cortical neurons by shunting cysteine from protein synthesis to glutathione. J Neurosci 1994; 14: 4385-92.
26. Honda O, Kuroda M, Joja I, Asaumi J, Takeda Y, Akaki S, Togami I, Kanazawa S, Kawasaki S, Hiraki Y. Assessment of secondary necrosis of Jurkat cells using a new microscopic system and double staining method with annexin V and propidium iodide. Int J Oncol 2000; 16: 283-8.
27. Green DR. Apoptotic pathways: ten minutes to dead. Cell 2005; 121: 671-4.
28. Danial NN, Korsmeyer SJ. Cell death: critical control points. Cell 2004; 116: 205-19.