c-Jun N-terminal kinase activation during warm hepatic ischemia/reperfusion injuries in a rat model

Wound Repair and Regeneration

Volumn 10, Issue 5, 2002, Pages 314-319

  Shinoda, Masahiro ^a   Shimazu, Motohide ^a   Matsuda, Satoshi ^a   Wakabayashi, Go ^a   Tanabe, Minoru ^a   Hoshino, Ken ^a   Kamei, Shusaku ^a   Koyasu, Shigeo ^a   Kitajima, Masaki ^a  

^a KEIO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

LIVER ENZYME; RADIOISOTOPE; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DEGENERATION; DISEASE MODEL; ENDOTHELIUM; ENZYME ACTIVATION; FLUOROGRAPHY; HISTOLOGY; LEUKOCYTE ADHERENCE; LIVER CELL; LIVER ISCHEMIA; LIVER SURGERY; LIVER TRANSPLANTATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT; REPERFUSION INJURY; RISK FACTOR;

ANIMALS; COLORING AGENTS; ENZYME ACTIVATION; FLUORESCEINS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIVER; LIVER DISEASES; LIVER FUNCTION TESTS; MALE; MICROSCOPY, FLUORESCENCE; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, ANIMAL; PROPIDIUM; RATS; RATS, WISTAR; REPERFUSION INJURY; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0036427195     PISSN: 10671927     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1524-475X.2002.t01-1-10507.x     Document Type: Article

References (12)

1. Starzl TE, Demetris AJ, Van Thiel D. Liver transplantation. N Engl J Med 1989;321:1014-22.
2. Suzuki S, Toledo-Pereyra LH, Rodriguez FJ, Cejalvo D. Neutrophil infiltration as an important factor in liver ischemia and reperfusion injury. Transplantation 1993;55:1265-72.
3. Marzi I, Knee J, Menger MD, Harbauer G, Bühren V. Hepatic microcirculatory disturbances due to portal vein clamping in the orthotopic rat liver transplantation model. Transplantation 1991;52:432-6.
4. Shito M, Wakabayashi G, Ueda M, Shimazu M, Shirasugi N, Endo M, Mukai M, Kitajima M. Interleukin-1 receptor blockade reduces tumor necrosis factor production, tissue injury, and mortality after hepatic ischemia-reperfusion in the rat. Transplantation 1997;63:143-8.
5. Shirasugi N, Wakabayashi G, Shimazu M, Oshima A, Shito M, Kawachi S, Karahashi T, Kumamoto Y, Yoshida M, Kitajima M. Up-regulation of oxygen-derived free radicals by interleukin-1 in hepatic ischemia/reperfusion injury. Transplantation 1997;64:1398-403.
6. Colletti LM, Remick DG, Burtch GD, Kunkel SL, Strieter RM, Campbell DA Jr. Role of tumor necrosis factor-α in the pathophysiologic alterations after hepatic ischemia/reperfusion injury in the rat. J Clin Invest 1990;85:1936-43.
7. Hoffmeyer A, Grosse-Wilde A, Flory E, Neufeld B, Kunz M, Rapp UR, Ludwig S. Different MAPK signaling pathways cooperate to regulate TNFα gene expression in T lymphocyte. J Biol Chem 1999;274:4319-27.
8. Shimohashi N, Nakamuta M, Uchimura K, Sugimoto R, Iwamoto H, Enjoji M, Nawata H. Selenoorganic compound, ebselen, inhibits nitric oxide and tumor necrosis factor-alpha production by the modulation of jun-N-terminal kinase and the NF-kappab signaling pathway in rat Kupffer cells. J Cell Biochem 2000;78:595-606.
9. Suematsu M, DeLano FA, Poole D, Engler RL, Miyasaka M, Zweifach BW, Schmid-Schonbein GW. Spatial and temporal correlation between leukocyte behavior and cell injury in postischemic rat skeletal muscle microcirculation. Lab Invest 1994;70:684-95.
10. Clark BD, Bedrosian I, Schindler R, Cominelli F, Cannon JG, Shaw AR, Dinarello CA. Detection of interleukin 1α and 1β in rabbit tissues during endotoxemia using sensitive radioimmunoassays. J Appl Physiol 1991;71:2412-8.
11. Matsuda S, Moliguchi T, Koyasu S, Nishida E. T lymphocyte activation signals for interleukin-2 production involve activation of MKK6-p38 and MKK7-SAPK/JNK signaling pathways sensitive to cyclosporin A. J Biol Chem 1998;273:12378-82.
12. Takehana K, Sato S, Kobayasi T, Maeda T. A radicicol-related macrocyclic nonaketide compound, antibiotic LL-Z1640-2, inhibits the JNK/p38 pathways in signal-specific manner. Biochem Biophys Res Commun 1999;257:19-23.