Differentiation of adoptees at high versus low genetic risk for schizophrenia by adjusted MMPI indices

European Psychiatry

Volumn 21, Issue 4, 2006, Pages 245-250

  Siira, Virva ^a   Wahlberg, Karl Erik ^a   Miettunen, Jouko ^a   Tienari, Pekka ^a   Làksy, Kristian ^a  

^a UNIVERSITY OF OULU   (Finland)

Author keywords

Adoption study; Demographic variables; High risk study; MMPI; Schizophrenia

Indexed keywords

ADULT; AGE DISTRIBUTION; ARTICLE; CLINICAL ASSESSMENT; CONTROLLED STUDY; FEMALE; GENETIC RISK; HIGH RISK POPULATION; HOSTILITY; HUMAN; HYPOMANIA; MAJOR CLINICAL STUDY; MALE; MINNESOTA MULTIPHASIC PERSONALITY INVENTORY; PRIORITY JOURNAL; PSYCHOMETRY; SCHIZOPHRENIA; SEX RATIO; ADOPTION; COMPARATIVE STUDY; FINLAND; GENETIC PREDISPOSITION; GENETICS; MOTHER; PSYCHOLOGICAL ASPECT; PSYCHOLOGY; REFERENCE VALUE; RISK; STATISTICS;

ADOPTION; ADULT; FEMALE; FINLAND; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MMPI; MOTHERS; PSYCHOMETRICS; REFERENCE VALUES; RISK; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY;

EID: 33745235262     PISSN: 09249338     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eurpsy.2006.01.007     Document Type: Article

References (59)

1. rd ed. revised (1987), American Psychiatric Press, Washington, DC
2. Amminger G.P., Pape S., Rock D., Roberts S.A., Squires-Wheeler E., Kestenbaum C., et al. The New York High-Risk Project: comorbidity for axis I disorders are preceded by childhood behavioral disturbance. J. Nerv. Ment. Dis. 188 (2000) 751-756
3. Bland M. An introduction to medical statistics (1995), Oxford University Press, Oxford
4. Bolinskey P.K., Gottesman I.I., Nichols D.S., Shapiro B.M., Roberts S.A., Adamo U.H., et al. A new MMPI-derived indicator of liability to develop schizophrenia: evidence from the New York high-risk project. Assessment 8 (2001) 127-143
5. Carter J.W., Parnas J., Cannon T.D., Schulsinger F., and Mednick S.A. MMPI variables predictive of schizophrenia in the Copenhagen High-Risk Project: a 25-year follow-up. Acta Psychiatr. Scand. 99 (1999) 432-440
6. Cornblatt B.A., Obuchowski M., Roberts S., Pollack S., and Erlenmeyer-Kimling L. Cognitive and behavioral precursors of schizophrenia. Dev. Psychopathol. 11 (1999) 487-508
7. Curran P.J., West S.G., and Finch J.F. The robustness of test statistics to nonnormality and specification error in confirmatory factor analysis. Psychol. Methods 1 (1996) 16-29
8. Dahlstrom W.G., Welsh G.S., and Dahlstrom L. An MMPI handbook, volume 1, clinical interpretation (1982), University of Minnesota Press, Minneapolis
9. Davis W.E. Age and the discriminative "power" of the MMPI with schizophrenic and nonschizophrenic patients. J. Consult. Clin. Psychol. 38 (1972) 151
10. Eichman W.J. Discrimination of female schizophrenics with configural analysis of the MMPI profile. J. Consult. Psychol. 23 (1959) 442-449
11. Erlenmeyer-Kimling L. Neurobehavioral deficits in offspring of schizophrenic parents: liability indicators and predictors of illness. Am. J. Med. Genet. B Neuropsychiatr. Genet. 97 (2000) 65-71
12. Erlenmeyer-Kimling L. Early neurobehavioral deficits as phenotypic indicators of the schizophrenia genotype and predictors of later psychosis. Am. J. Med. Genet. A 105 (2001) 23-24
13. Friedman A.F., Webb J.T., and Lewak R. Psychological assessment with the MMPI (1989), Lawrence Erlbaum Associates, New Jersey
14. Golden R.R., and Meehl P.E. Detection of the schizoid taxon with MMPI indicators. J. Abnorm. Psychol. 88 (1979) 217-233
15. Goodson J.H., and King G.D. A clinical and actuarial study on the validity of the Goldberg index for the MMPI. J. Clin. Psychol. 32 (1976) 328-335
16. Gottesman I.I., and Shields J. Schizophrenia and genetics: a twin study vantage point (1972), Academic Press, San Diego
17. Gottesman I.I. Complications to the complex inheritance of schizophrenia. Clin. Genet. 46 (1994) 116-123
18. Greene R.L. The MMPI: an interpretive manual (1980), Grune and Stratton, New York
19. Grove W.M. Psychometric detection of schizotypy. Psychol. Bull. 92 1 (1982) 27-38
20. Haier R.J., Rosenthal D., and Wender P.H. MMPI assessment of psychopathology in adopted-away offspring of schizophrenics. Arch. Gen. Psychiatry 35 (1978) 171-175
21. Hanson D.R., Gottesman I.I., and Heston L.L. Some possible childhood indicators of adult schizophrenia inferred from children of schizophrenics. Br. J. Psychiatry 129 (1976) 142-154
22. Johnstone E.C., Abukmeil S.S., Byrne M., Clafferty R., Grant E., Hodges A., et al. Edinburgh High Risk Study: findings after 4-year: demographic, attainment and psychopathological issues. Schizophr. Res. 46 (2000) 1-15
23. Kendler K.S., O'Neil F.A., Burke J., Murphy B., Duke F., Straub R.E., et al. Irish study of high-density schizophrenia families: field methods and power to detect linkage. Am. J. Med. Genet. B Neuropsychiatr. Genet. 67 (1996) 179-190
24. Kendler K.S., Myers J.M., O'Neill F.A., Martin R., Murphy B., MacLean C.J., et al. Clinical features of schizophrenia and linkage to chromosomes 5q, 6p, 8p, and 10p in the Irish study of high-density schizophrenia families. Am. J. Psychiatry 157 (2000) 402-408
25. Kugelmass S., Faber N., Ingraham L.J., Frenkel E., Nathan M., Mirsky A.F., et al. Reanalysis of SCOR and anxiety measures in the Israeli High-Risk Study. Schizophr. Bull. 21 (1995) 205-217
26. MacCrimmon D.J., Cleghorn J.M., Asarnow R.F., and Steffy R.A. Children at risk for schizophrenia: clinical and attentional characteristics. Arch. Gen. Psychiatry 37 (1980) 671-674
27. nd ed (1989), Chapman and Hall, New York
28. Metsänen M., Wahlberg K.-E., Saarento O., Tarvainen T., Miettunen J., Koistinen P., et al. Early presence of thought disorder as a prospective sign of mental disorder. Psychiatry Res. 125 (2004) 193-203
29. Miller T.W., and Paciello R.A. Discriminative dimension of the MMPI as a function of age and psychopathology. J. Clin. Psychol. 36 (1980) 758-759
30. Minnesota Veterans Administration Hospital-MMPI Research Laboratory. An atlas for the P-code system of MMPI interpretation (1975), MN: Veterans' Administration Hospital, Minneapolis
31. Moldin S.O., Gottesman I.I., and Erlenmeyer-Kimling L. Psychometric validation of psychiatric diagnoses in the New York high-risk study. Psychiatry Res. 22 (1987) 159-177
32. Moldin S.O., Gottesman I.I., and Erlenmeyer-Kimling L. Searching for the psychometric boundaries of schizophrenia: evidence from the New York high-risk study. J. Abnorm. Psychol. 96 (1987) 354-363
33. Moldin S.O., Gottesman I.I., Erlenmeyer-Kimling L., and Cornblatt B.A. Psychometric deviance in offspring at risk for schizophrenia: I. Initial delineation of a distinct subgroup. Psychiatry Res. 32 (1990) 297-310
34. Moldin S.O., Rice J.P., Gottesman I.I., and Erlenmeyer-Kimling L. Psychometric deviance in offspring at risk for schizophrenia: II. resolving heterogeneity through admixture analysis. Psychiatry Res. 32 (1990) 311-322
35. Moldin S.O., Rice J.P., Gottesman I.I., and Erlenmeyer-Kimling L. Transmission of a psychometric indicator for liability to schizophrenia in normal families. Genet. Epidemiol. 7 (1990) 163-176
36. Newmark C.S., Gentry L., Simpson M., and Jones T. MMPI criteria for diagnosing schizophrenia. J. Pers. Assess. 42 (1978) 366-373
37. Newmark C.S., Gentry L., and Whitt J.K. Utility of MMPI indices of schizophrenia with adolescents. J. Clin. Psychol. 39 (1983) 170-172
38. Newmark C.S., Jones M.T., McKee D.C., Simpson M., Boren R.B., and Prillaman K. Using discriminant function analysis with clinical, demographic, and historical variables to diagnose schizophrenia. Br. J. Med. Psychol. 53 (1980) 365-374
39. Newmark C.S., and Hutchins T.C. Age and MMPI indices of schizophrenia. J. Clin. Psychol. 36 (1980) 768-769
40. Nuechterlein K.H. Vulnerability models for schizophrenia: state of the art. In: Häfner H., Gattaz W.F., and Janzarik W. (Eds). Search for the causes of schizophrenia (1987), Springer-Verlag, Giessen 297-316
41. Nuechterlein K.H., and Dawson M.E. A heuristic vulnerability/stress model of schizophrenic episodes. Schizophr. Bull. 10 (1984) 300-312
42. Olin S.S., John R.S., and Mednic S.A. Assessing the predictive value of teacher reports in a high risk sample for schizophrenia: a ROC analysis. Schizophr. Res. 16 (1995) 53-66
43. Rosen A. Development of MMPI scales based on a reference group of psychiatric patients. Psychol. Monogr. 76 (1962) 1-25
44. Rosenthal D. Genetic theory and abnormal behavior (1970), McGraw-Hill, New York
45. Siira V., Wahlberg K.-E., Miettunen J., Läksy K., and Tienari P. Psychometric deviance measured by MMPI in adoptees at high risk for schizophrenia and their adoptive controls. J. Pers. Assess. 83 1 (2004) 14-21
46. Sillitti J. MMPI-derived indicators of organic brain dysfunction. J. Clin. Psychol. 38 (1982) 601-605
47. Statistics Finland. 17 (1983), The Center of Statistics, Helsinki
48. Tienari P., Sorri A., Lahti I., Naarala M., Wahlberg K.-E., Moring J., et al. Genetic and psychosocial factors in schizophrenia: the Finnish Adoptive Family Study. Schizophr. Bull. 13 (1987) 477-484
49. Tienari P., Wynne L.C., Moring J., Läksy K., Nieminen P., Sorri A., et al. Finnish Adoptive Family Study of Schizophrenia: sample selection and adoptee DSM-III-R diagnoses. Acta Psychiatr. Scand. 101 (2000) 433-443
50. Tienari P., Wynne L.C., Sorri A., Lahti I., Läksy K., Moring J., et al. Genotype-environment interaction in schizophrenia-spectrum disorder. Br. J. Psychiatry 184 (2004) 216-222
51. Tienari P., Wynne L.C., Läksy K., Moring J., Nieminen P., Sorri A., et al. Genetic boundaries of the schizophrenia spectrum: evidence from the Finnish Adoptive Family Study of Schizophrenia. Am. J. Psychiatry 160 (2003) 1587-1594
52. Walters G.D. The MMPI and schizophrenia: a review. Schizophr. Bull. 9 (1983) 226-246
53. Walters G.D. Schizophrenia. In: Greene R.L. (Ed). The MMPI: use with specific populations (1988), Grune and Stratton, Philadelphia 50-73
54. Watson C.G. An MMPI scale to separate braindamaged from schizophrenic men. J. Consult. Clin. Psychol. 36 (1971) 121-125
55. Watt N.F. Patterns of childhood social development in adult schizophrenics. Arch. Gen. Psychiatry 35 2 (1978) 160-165
56. Wauck I.A. Schizophrenia and the MMPI. J. Clin. Psychol. 6 (1950) 279-284
57. Wiggins J.S. Substantive dimensions of self-report in the MMPI item pool. Psychol. Monogr. 80 (1966) 1-42 (Whole No. 630)
58. Zubin J., and Spring B. Vulnerability-a new view of schizophrenia. J. Abnorm. Psychol. 86 (1977) 103-126
59. Zubin J., Steinhauer S.R., Day R., and van Kammen D.P. Schizophrenia at the crossroads: a blueprint for the 80s. Compr. Psychiatry 26 (1985) 217-240