A new MMPI-derived indicator of liability to develop schizophrenia: Evidence from the New York High-Risk Project

Assessment

Volumn 8, Issue 2, 2001, Pages 127-143

  Bolinskey, P Kevin ^a   Gottesman, Irving I ^a   Nichols, David S ^b   Shapiro, Barbara M ^c   Roberts, Simone A ^c   Adamo, Ulla H ^c   Erlenmeyer Kimling, L ^c,d  

^a UNIVERSITY OF VIRGINIA   (United States)

^b New York State Psychiatric Institute ^*  (United States)

^c NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^d NONE   (United States)

Author keywords

Genetics; MMPI; New York High Risk Project; Offspring of schizophrenics; Schizophrenia

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; DISEASE PREDISPOSITION; FEMALE; GENETICS; HUMAN; LONGITUDINAL STUDY; MALE; MIDDLE AGED; MINNESOTA MULTIPHASIC PERSONALITY INVENTORY; PSYCHOMETRY; PSYCHOSIS; RISK ASSESSMENT; SCHIZOPHRENIA; SOCIAL ENVIRONMENT; STATISTICS;

ADOLESCENT; ADULT; DISEASE SUSCEPTIBILITY; FEMALE; HUMANS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; MMPI; PSYCHOMETRICS; PSYCHOTIC DISORDERS; RISK ASSESSMENT; SCHIZOPHRENIA; SOCIAL ENVIRONMENT; STATISTICS;

EID: 0035375811     PISSN: 10731911     EISSN: None     Source Type: Journal    
DOI: 10.1177/107319110100800202     Document Type: Article

References (56)

1. Amminger, G. P., Pape, S., Rock, D., Roberts, S. A., Ott, S. L., Squires-Wheeler, E., Kestenbaum, C., & Erlenmeyer-Kimling, L. (1999). Relationship between childhood behavioral disturbance and later schizophrenia in the New York High-Risk Project. American Journal of Psychiatry, 156, 525-530.
2. Archer, R. P. (1997). MMPI-A: Assessing adolescent psychopathology (2nd ed.). Mahwah, NJ: Erlbaum.
3. Butcher, J. N., Kendall, P. C., & Hoffman, N. (1980). MMPI short forms: CAUTION. Journal of Consulting Psychology, 48, 275-278.
4. Campbell, D. T., & Fiske, D. W. (1959). Convergent and discriminant validation by the multitrait-multimethod matrix. Psychological Bulletin, 56, 81-104.
5. Cardno, A. G., & Gottesman, I.I. (2000). Twin studies of schizophrenia: From bow-and-arrow concordances to Star Wars Mx and functional genomics. American Journal of Medical Genetics, 97, 12-17.
6. Carter, J. W., Parnas, J., Cannon, T. D., Schulsinger, F., & Mednick, S. A. (1999). MMPI variables predictive of schizophrenia in the Copenhagen High Risk Project: A 25-year follow-up. Acta Psychiatrica Scandinavica, 99, 432-440.
7. Cornblatt, B., & Erlenmeyer-Kimling, L. (1985). Global attentional deviance as a marker of risk for schizophrenia: Specificity and predictive validity. Journal of Abnormal Psychology, 94, 470-486.
8. Cornblatt, B., Obuchowski, M., Roberts, S., Pollack, S., & Erlenmeyer-Kimling L. (1999). Cognitive and behavioral precursors of schizophrenia. Developmental Psychopathology, 11, 487-508.
9. Dawes, R. (1962). A note on base rates and psychometric efficiency. Journal of Consulting Psychology, 26, 422-424.
10. DiLalla, D. L., Gottesman, I. I., & Carey, G. (2000). Madness beyond the threshold? Associations between personality and psychopathology. In D. L. Molfese & V. J. Molfese (Eds.), Temperament and personality development across the lifespan (pp. 172-210). Los Angeles: Erlbaum Assoc.
11. Erlenmeyer-Kimling, L. (2000). Neurobehavioral deficits in offspring of schizophrenic parents: Indicators and predictors of illness. American Journal of Medical Genetics, 97, 65-71.
12. Erlenmeyer-Kimling, L., & Cornblatt, B. (1988). The New York High-Risk Project: A follow-up report. Schizophrenia Bulletin, 13, 451-461.
13. Erlenmeyer-Kimling, L., Marcuse, Y., Cornblatt, B., Friedman, D., Rainer, J. D., & Rutschmann, J. (1984). The New York High-Risk Project. In N. Watt, E. J. Anthony, L. Wynne, & J. Rolfe (Eds.), Children at risk for schizophrenia: A longitudinal perspective (pp. 169-189). New York: Cambridge University Press.
14. Erlenmeyer-Kimling, L., Rock, D., Roberts, S. A., Janal, M., Kestenbaum, C., Cornblatt, B., Adamo, U. H., & Gottesman, I.I. (2000). Attention, memory, and motor skills as childhood predictors of schizophrenia-related psychoses: The New York High-Risk Project. American Journal of Psychiatry, 157, 1416-1422.
15. Goldberg, L. R. (1965). Diagnosticians vs. diagnostic signs: The diagnosis of psychosis vs. neurosis from the MMPI. Psychological Monographs, 79 (Whole No. 602).
16. Goldberg, L. R. (1969). The search for configural relationships in personality assessment: The diagnosis of psychosis vs. neurosis from the MMPI. Multivariate Behavioral Research, 4, 523-536.
17. Gottesman, I.I. (1991). Schizophrenia genesis: The origins of madness. New York: W. H. Freeman.
18. Gottesman, I. I. (1994). Complications to the complex inheritance of schizophrenia. Clinical Genetics, 46, 116-123.
19. Gottesman, I. I., & Bertelsen, A. (1989). Confirming unexpressed genotypes for schizophrenia: Risks in the offspring of Fischer's Danish identical and fraternal discordant twins. Archives of General Psychiatry, 46, 867-872.
20. Gottesman, I. I., & Prescott, C. A. (1989). Abuses of the MacAndrew MMPI alcoholism scale: A critical review. Clinical Psychology Review, 9, 223-242.
21. Gottesman, I. I., & Shields, J. (1972). Schizophrenia and genetics: A twin study vantage point. New York: Academic Press.
22. Greene, R. L. (1980). The MMPI: An interpretive manual. Orlando, FL: Grune & Stratton.
23. Gross, G. (1997). The onset of schizophrenia. Schizophrenia Research, 28, 187-198.
24. Hanson, D. R., Gottesman, I. I., & Heston, L. L. (1976). Some possible childhood indicators of adult schizophrenia from children of schizophrenics. British Journal of Psychiatry, 129, 142-154.
25. Hathaway, S. R., & McKinley, J. C. (1983). Manual for administration and scoring of the MMPI. Minneapolis, MN: National Computer Systems.
26. Kendler, K. S., McGuire, M., Gruenberg, A. M., & Walsh, D. (1994). Clinical heterogeneity in schizophrenia and the pattern of psychopathology in relatives: Results from an epidemiologically based family study. Acta Psychiatrica Scandinavica, 89, 294-300.
27. Kendler, K. S., Myers J. M., O'Neill, F. A., Martin, R., Murphy, B., MacLean, C. J., Walsh, D., & Straub, R. E. (2000). Clinical features of schizophrenia and linkage to chromosomes 5q, 6p, 8p, and 10p in the Irish Study of High-Density Schizophrenia Families. American Journal of Psychiatry, 157, 402-408.
28. Kety, S. S. (1999). Mental illness and the science of brain and behavior. Nature Medicine, 5, 113-116.
29. Lenzenweger, M. F. (1998). Schizotypy and schizotypic psychopathology: Mapping an alternative expression of schizophrenia liability. In M. F. Lenzenweger & R. H. Dworkin (Eds.), Origins and development of schizophrenia: Advances in experimental psychopathology (pp. 93-121). Washington, DC: American Psychological Association.
30. Levinson, D. F., & Mowry, B. J. (2000). Genetics of schizophrenia. In D. W. Pfaff (Ed.), Genetic influences on neural and behavioral functions (pp. 47-82). Boca Raton, FL: CRC Press.
31. McGue, M., & Gottesman, I. I. (1989). Genetic linkage in schizophrenia: Perspectives from genetic epidemiology. Schizophrenia Bulletin, 15, 453-464.
32. Meehl, P. E. (1990). Toward and integrated theory of schizotaxia, schizotypy, and schizophrenia. Journal of Personality Disorders, 4, 1-99.
33. Merritt, R. D., Balogh, D. W., & Kok, C. J. (1998). DSM-IV Cluster A personality disorders among young adults with a 2-7-8 MMPI profile. Assessment, 5, 273-285.
34. Minnesota Veterans Administration Hospital-MMPI Research Laboratory. (1975). An atlas for the P-code system of MMPI interpretation. Minneapolis, MN: Minneapolis VA Hospital.
35. Moises, H. W., & Gottesman, I. I. (2000) Genetics, risk factors, and personality factors. In F. Henn, H. Helmchen, H. Lauter, & N. Sartorius (Eds.). Contemporary psychiatry (pp. 47-59). Heidelberg, Germany: Springer Verlag.
36. Moldin, S. O. (1988). Psychometric indicators of liability to schizophrenia in children at genetic risk. (Doctoral dissertation, Yeshiva University, 1988). University Microfilms International, 8918037.
37. Moldin, S. O., Gottesman, I. I., & Erlenmeyer-Kimling, L. (1987a). Psychometric validation of psychiatric diagnosis in the New York High-Risk Study. Psychiatry Research, 22, 159-177.
38. Moldin, S. O., Gottesman, I. I., & Erlenmeyer-Kimling, L. (1987b). Searching for the psychometric boundaries of schizophrenia: Evidence from the New York High-Risk Study. Journal of Abnormal Psychology, 96, 354-363.
39. Moldin, S. O., Gottesman, I. L, Erlenmeyer-Kimling, L., & Cornblatt, B. A. (1990). Psychometric deviance in offspring at risk for schizophrenia: I. Initial delineation of a distinct subgroup. Psychiatry Research, 32, 297-310.
40. Moldin, S. O., Gottesman, I. L, Rice, J. P., & Erlenmeyer-Kimling, L. (1991). Replicated psychometric correlates of schizophrenia. American Journal of Psychiatry, 148, 762-767.
41. Moldin, S. O., Rice, J. P., Gottesman, I. I., & Erlenmeyer-Kimling, L. (1990). Psychometric deviance in offspring at risk for schizophrenia: II. Resolving heterogeneity through admixture analysis. Psychiatry Research, 32, 311-322.
42. Nuechterlein, K. H., Asarnow, R. F., Subotnik, K. L., Fogelson, D. L., Ventura, J., Torquato, R. D., & Dawson, M. E. (1998). Neurocognitive vulnerability factors for schizophrenia: Convergence across genetic risk studies and longitudinal trait-state studies. In M. F. Lenzenweger & R. H. Dworkin (Eds.), Origins and development of schizophrenia: Advances in experimental psychopathology (pp. 299-327). Washington, DC: American Psychological Association.
43. Nuechterlein, K. H., Dawson, M. E., Gitlin, M., Ventura, J., Goldstein, M. J., Snyder, K. S., Yee, C. M., & Mintx, J. (1992). Developmental processes in schizophrenic disorders: Longitudinal studies of vulnerability and stress. Schizophrenia Bulletin, 18, 387-425.
44. Pearson, J. S., & Kley, I. B. (1957). On the application of genetic expectancies as age-specific rates in the study of human behavior disorders. Psychological Bulletin, 54, 406-420.
45. Petronis, A., & Gottesman, I. I. (2000). Psychiatric epigenetics: A new focus for the new century. Molecular Psychiatry, 5, 342-346.
46. Rosen, A. (1958). Differentiation of diagnostic groups by individual MMPI scales. Journal of Consulting Psychology, 22, 453-457.
47. Rosen, A. (1962). Development of MMPI scales based on a reference group of psychiatric patients. Psychological Monographs, 76, 1-25.
48. Rosen, A. (1966). Stability of new MMPI scales and statistical procedures for evaluation changes and differences in psychiatric patients. Journal of Consulting Psychology, 30, 142-145.
49. Sing, C. F., Haviland M. B., & Reilly, S. L. (1996). Genetic architecture of common multifactorial diseases. Ciba Foundation Symposium, 197, 211-29.
50. Spitzer, R. L., & Endicott, J. (1978). Schedule for Affective Disorders and Schizophrenia - Lifetime Version (3rd ed.). New York: New York State Psychiatric Institute, Biometrics Research.
51. Spitzer, R. L., Endicott, J., & Robins, E. (1975). Research Diagnostic Criteria (RDC) for a selected group of functional disorders (2nd ed.). New York: New York State Psychiatric Institute, Biometrics Research.
52. Tienari, P., Wynne, L. C., Moring, J., Läksy, K., Nieminen, P., Sorri, A., Lahti, I., Wahlberg, K. -E., Naarala, M., Kurki-Suonio, K., Saarentò, O., Koistinen, P., Tarvainen, T., Hakko, H., & Miettunen, J. (2000). Finnish adoptive family study: Sample selection and adoptee DSM-III-R diagnoses. Ada Psychiatrica Scandinavica, 101, 433-443.
53. Todd, J. A. (1999). From genome to aetiology in a multi-factorial disease, Type 1 diabetes. Bioessays, 21, 164-174.
54. Wiggins, J. S. (1966). Substantive dimensions of self-report in the MMPI item pool. Psychological Monographs, 80, 1-42.
55. Woolf, C. M. (1997). Does the genotype for schizophrenia often remain unexpressed because of canalization and stochastic events during development? Psychological Medicine, 27, 659-668.
56. Zalewski, C. E., & Gottesman, I. I. (1991). (Hu)man versus mean revisited: MMPI group data and psychiatric diagnosis. Journal of Abnormal Psychology, 100, 562-568.