Relationship of osteocalcin and matrix Gla protein gene polymorphisms to serum osteocalcin levels and bone mineral density in postmenopausal Korean women

Menopause

Volumn 13, Issue 3, 2006, Pages 467-473

  Kim, Jung Gu ^a,b   Ku, Seung Yup ^a,b   Lee, Dong Ock ^a   Jee, Byung Chul ^a   Suh, Chang Suk ^a,b   Kim, Seok Hyun ^a,b   Choi, Young Min ^a,b   Moon, Shin Yong ^a,b  

^a Seoul National University   (South Korea)

^b Seoul National University Hospital   (South Korea)

Author keywords

Bone mineral density; Gla protein; Menopause; Osteocalcin; Polymorphism

Indexed keywords

ALKALINE PHOSPHATASE BONE ISOENZYME; CARBOXY TERMINAL TELOPEPTIDE; COLLAGEN TYPE 1; OSTEOCALCIN;

ADULT; AGED; ALLELE; ARTICLE; BODY MASS; BONE DENSITY; BONE TURNOVER; FEMALE; FEMUR NECK; GENE; GENETIC POLYMORPHISM; GENOTYPE; HIND III GENE; HUMAN; LUMBAR SPINE; MAJOR CLINICAL STUDY; POSTMENOPAUSE; SOUTH KOREA;

AGED; ALKALINE PHOSPHATASE; ASIAN CONTINENTAL ANCESTRY GROUP; BONE DENSITY; BONE REMODELING; CALCIUM-BINDING PROTEINS; COLLAGEN TYPE I; DNA; EXTRACELLULAR MATRIX PROTEINS; FEMALE; FEMUR NECK; HUMANS; KOREA; LUMBAR VERTEBRAE; MIDDLE AGED; OSTEOCALCIN; OSTEOPOROSIS, POSTMENOPAUSAL; PEPTIDES; POLYMORPHISM, GENETIC;

EID: 33745233063     PISSN: 10723714     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.gme.0000182803.06762.fb     Document Type: Article

References (24)

1. Osteoporosis prevention diagnosis, and therapy. NIH Consensus Statement 2000;17:1-45.
2. Jouanny P, Guillemin F, Kuntz C, Jaendel C, Pourel J. Environmental and genetic factors affecting bone mass. Similarity of bone density among members of healthy families. Arthritis Rheum 1995;38:61-67.
3. Liu YZ, Liu YJ, Recker RR, Deng HW. Molecular studies of identification of genes for osteoporosis: the 2002 update. J Endocrinol 2003;177:147-196.
4. Cho SH, Hwang YY, Lee JA, Choi YY, Cho SS. Prevalence of osteoporosis based on bone density measurement in Korea women. Korean J Obstet Gynecol 1999;42:821-825.
5. Rowe SM, Yoon TR, Kim YS, Lee GH. An epidemiologic study of hip fracture in Honam, Korea. Int Orthop 1993;17:139-143.
6. Kim JG, Lim KS, Kim EK, Choi YM, Lee JY. Association of vitamin D receptor and estrogen receptor gene polymorphisms with bone mass in postmenopausal Korean women. Menopause 2001;8:222-228.
7. Kim JG, Roh KR, Lee JY. The relationship among serum insulin-like growth factor-I, insulin-like growth factor-I gene polymorphism and bone mineral density in postmenopausal women in Korea. Am J Obstet Gynecol 2002;186:345-350.
8. Kim JG, Kwon JH, Kim SH, Choi YM, Moon SY, Lee JY. Association between vitamin D receptor gene haplotypes and bone mass in postmenopausal Korean women. Am J Obstet Gynecol 2003;189:1234-1240.
9. Hauschka PV, Lian JB, Cole DEC, Gundberg CM. Osteocalcin and matrix Gla protein: vitamin K-dependent prtoteins in bone. Physiol Rev 1989;69:990-1047.
10. Glowacki J, Rey C, Glimcher MJ, Cox KA, Lian J. A role for osteocalcin in osteoclast differentiation. J Cell Biochem 1991;45:292-302.
11. Cancela L, Hsieh CL, Francke U Price PA. Molecular structure, chromosome assignment, and promotor organization of the human matrix Gla protein gene. J Biol Chem 1990;265:15040-15048.
12. Luo G, Ducy P, McKee MD, et al. Spontaneous calcification of arteries and cartilage in mice lacking matrix Gla protein. Nature 1997;386:78-81.
13. Dohi Y, Iki M, Ohgushi H, et al. A novel polymorphism in the promoter region for the human osteocalcin gene: the possibility of a correlation with bone mineral density in postmenopausal Japanese women. J Bone Miner Res 1998;13:1633-1639.
14. Watanabe I, Tsukamoto JK, Shiba T, Emi Ml. Isolation and radiation hybrid mapping of a dinuclotide repeat polymorphism at the human matrix Gla (MGP) locus. J Hum Genet 1998;43:75-76.
15. Yamada Y, Ando F, Niino N, Shimokata H. Association of polymorphisms of interleukin-6, osteocalcin, and vitamin D receptor genes, alone or in combination, with bone mineral density in community-dwelling Japanese women and men. J Clin Endocrinol Metab 2003;88:3372-3378.
16. Chen HY, Tsai HD, Chen WC, Wu JY, Tsai FJ, Tsai CH. Relation of polymorphism in the promotor region for the human osteocalcin gene to bone mineral density and occurrence of osteoporosis in postmenopausal Chinese women in Taiwan. J Clin Lab Anal 2001;15:251-255.
17. Sowers M, Willing M, Burns T, et al. Genetic markers, bone mineral density, and serum osteocalcin levels. J Bone Miner Res 1999;14:1411-1419.
18. Mo XY, Cao CK, Xu FH, et al. Lack of association between the HindIII RFLP of the osteocalcin (BGP) gene and bone mineral density (BMD) in healthy pre- and postmenopausal Chinese women. J Bone Miner Metab 2004;22:264-269.
19. Ota N, Hunt S, Nakajima T, et al. Linkage of interleukin 6 locus to human osteopenia by sibling pair analysis. Hum Gent 1999;105:253-257.
20. Tsukamoto K, Orimo H, Hosoi T, Miyao M, Yoshida H, Watanabe S, et al. Association of bone mineral density with polymorphism of the human matrix Gla protein locus in elderly women. J Bone Miner Metab 2000;18:27-30.
21. Kanis JA, Melton LJ 3rd, Christiansen C, Johnston CC, Khaltaev N. The diagnosis of osteoporosis. J Bone Miner Res. 1994;9:1137-1141.
22. Livshits G, Yakovenko C, Kobyliansky E. Quantitative genetic analysis of circulating levels of biochemical markers of bone formation. Am J Med Genet 2000;94:324-331.
23. Morrison NA, Yeoman R, Kelly PJ, Eisman JA. Contribution of trans-acting factor alleles to normal physiological variability: vitamin D receptor gene polymorphism and circulation osteocalcin. Proc Natl Acad Sci U S A 1992;89:6665-6669.
24. Ducy P, Desbois C, Boyce B, et al. Increased bone formation in osteocalcin-deficient mice. Nature 1996;382:448-452.