Cellular senescence, cancer, and organismal aging: A paradigm shift

Biochemical and Biophysical Research Communications

Volumn 344, Issue 1, 2006, Pages 1-2

  Lim, Chang Su ^a  

^a VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; PROTEIN P53;

AGING; CANCER INCIDENCE; CANCER INHIBITION; CANCER MORTALITY; CARCINOGENESIS; CELL CYCLE ARREST; CELL DIVISION; CELL PROLIFERATION; CELL TRANSFORMATION; DNA DAMAGE; GENE ACTIVATION; HUMAN; IONIZING RADIATION; LONGEVITY; MOLECULAR MECHANICS; NONHUMAN; ONCOGENE; OXIDATIVE STRESS; PRIORITY JOURNAL; SENESCENCE; SHORT SURVEY; TELOMERE; ARTICLE; CELL AGING; MORTALITY; NEOPLASM;

AGING; CELL AGING; HUMANS; NEOPLASMS;

EID: 33745228077     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.03.161     Document Type: Short Survey

References (8)

1. Hayflick L. The limited in vitro lifetime of human diploid cell strains. Exp. Cell Res. 37 (1965) 614-636
2. Campisi J. From cells to organisms: can we learn about aging from cells in culture?. Exp. Gerontol. 36 4-6 (2001) 607-618
3. Dimri G.P., Lee X., Basile G., Acosta M., Scott G., Roskelley C., et al. A novel biomarker identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl. Acad. Sci. USA 92 (1995) 9363-9367
4. Campisi J. Cellular senescence and apoptosis: how cellular responses might influence aging phenotypes. Exp. Gerontol. 38 1-2 (2003) 5-11
5. Pompei F., and Wilson R. A quantitative model of cellular senescence influence on cancer and longevity. Toxicol. Ind. Health. 18 8 (2002) 365-376
6. C.S. Lim, Is cellular senescence hypothesis of aging antagonistically pleiotropic? Med Hypotheses 2006 (in press).
7. Agarwal S., Sharma S., Agrawal V., and Roy N. Caloric restriction augments ROS defense in S. cerevisiae, by a Sir2p independent mechanism. Free Radic. Res. 39 1 (2005) 55-62
8. Herbig U., Ferreira M., Condel L., Carey D., and Sedivy J.M. Cellular senescence in aging primates. Science 311 5765 (2006) 1257