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Volumn 127, Issue 7, 2006, Pages 901-908

New functionalized, differently fluorinated building-blocks via Michael addition to γ-fluoro-α-nitroalkenes

Author keywords

Michael additions, Nitroalkenes, Enamines

Indexed keywords


EID: 33745219816     PISSN: 00221139     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jfluchem.2006.03.017     Document Type: Article
Times cited : (26)

References (36)
  • 2
    • 33745189259 scopus 로고    scopus 로고
    • For a review see:
  • 4
    • 33745218179 scopus 로고    scopus 로고
    • see also:
  • 6
    • 33745199300 scopus 로고    scopus 로고
    • Few methods exist for the synthesis of β-fluoroalkyl γ-nitroketones, see for example: from 2-diazo-3-nitro-1,1,1-trifluoropropane:
  • 8
    • 33745193820 scopus 로고    scopus 로고
    • From 1,1,1-trifluoro-2-penten-4-one:
  • 11
    • 33745196336 scopus 로고    scopus 로고
    • From difluoromethylenephosphonate-derivatives:
  • 13
    • 33745223377 scopus 로고    scopus 로고
    • For a preliminary report see:
  • 20
    • 33745216342 scopus 로고    scopus 로고
    • The starting fluoroaldehyde-hydrates are commercially available. In the case of 1c, the ethyl hemiacetal of difluoroacetaldehyde was used. Although it is also commercially available, it was prepared by hydride reduction of ethyl difluoroacetate:
  • 22
    • 33745218180 scopus 로고    scopus 로고
    • 5 to give 1 (b.p. of nitromethane 101.2 °C; b.p. of 1b 103-105 °C)
  • 23
    • 33745218847 scopus 로고    scopus 로고
    • Preparation of silyl enolethers and related compounds:
  • 28
    • 33745219555 scopus 로고    scopus 로고
    • For a recent review on the Mukaiyama-aldol reaction:
  • 30
    • 33745200635 scopus 로고    scopus 로고
    • The enamines 7a-c were prepared as described in:


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.