Effects of tetrabromobisphenol A, brominated flame retardant, in ICR mice after prenatal and postnatal exposure

Food and Chemical Toxicology

Volumn 44, Issue 8, 2006, Pages 1408-1413

  Tada, Y ^a   Fujitani, T ^a   Yano, N ^a   Takahashi, H ^a   Yuzawa, K ^a   Ando, H ^a   Kubo, Y ^a   Nagasawa, A ^a   Ogata, A ^a   Kamimura, H ^a  

^a TOKYO METROPOLITAN INSTITUTE OF PUBLIC HEALTH   (Japan)

Author keywords

Flame retardant; Lipid metabolism; Liver lesion; Mice; Tetrabromobisphenol A

Indexed keywords

FLAME RETARDANT; TETRABROMOBISPHENOL A; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATROPHY; BODY WEIGHT; BROMINATION; CELL DEATH; CELL INFILTRATION; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG EFFECT; ENVIRONMENTAL EXPOSURE; FEMALE; FOOD INTAKE; HISTOLOGY; INFLAMMATORY CELL; KIDNEY CYST; KIDNEY INJURY; KIDNEY TUBULE; KIDNEY TUBULE DISORDER; LIPID METABOLISM; LIVER CELL; LIVER INJURY; LIVER WEIGHT; MALE; METABOLIC DISORDER; MOUSE; NONHUMAN; PERINATAL PERIOD; PRENATAL EXPOSURE;

ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; BLOOD GLUCOSE; BLOOD UREA NITROGEN; BODY WEIGHT; CHOLESTEROL; FEMALE; FLAME RETARDANTS; KIDNEY; LITTER SIZE; LIVER; MALE; MATERNAL EXPOSURE; MICE; MICE, INBRED ICR; ORGAN SIZE; POLYBROMINATED BIPHENYLS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; TRIGLYCERIDES;

EID: 33745218500     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2006.03.006     Document Type: Article

References (30)

1. Bergman Å., Athanasiadou M., Klasson W.E., and Sjödin A. Polybrominated environmental pollutants: human and wildlife exposures. Organohalogen Compounds 43 (1999) 89-92
2. Bromine Science and Environmental Forum, 2004. Available from: .
3. Darnerud P.O. Toxic effects of brominated flame retardants in man and wildlife. Environment International 29 (2003) 841-853
4. Darnerud P.O., Eriksen G.S., Johannesson T., Larsen P.B., and Viluksela M. Polybrominated diphenyl ethers: occurrence, dietary exposure, and toxicology. Environmental Health Perspectives 109 (2001) 49-68
5. de Wit C.A. An overview of brominated flame retardants in the environment. Chemosphere 46 (2002) 583-624
6. Eriksson P., Jakobsson E., and Fredriksson A. Brominated flame retardants: a novel class of developmental neurotoxicants in our environment?. Environmental Health Perspectives 109 (2001) 903-908
7. Fukuda N., Ito Y., Yamaguchi M., Mitumori K., Koizumi M., Hasegawa R., Kamata E., and Ema M. Unexpected nephrotoxicity induced by tetrabromobisphenol A in newborn rats. Toxicology Letters 21 (2004) 145-155
8. Gad S.C., and Weil C.S. Statistics for toxicologist. In: Hayes A.W. (Ed). Principles and Methods of Toxicology. third ed. (1994), Raven Press, New York 221-274
9. Hakk H., Larsen G., Bergman A., and Örn U. Metabolism, excretion and distribution of the flame retardant tetrabromobisphenol-A in conventional and bile-duct cannulated rats. Xenobiotica 30 (2000) 881-890
10. Harada T., Enomoto A., Boorman G.A., and Maronpot R.R. Liver and gallbladder. In: Maronpot R.R. (Ed). Pathology of the Mouse (1999), Cache River Press, Vienna 119-183
11. Helleday T., Tuominen K.L., Bergman A., and Jenssen D. Brominated flame retardants induce intragenic recombination in mammalian cells. Mutation Research 439 (1999) 137-147
12. IPCS/WHO, 1995. Tetrabromobisphenol A and derivatives. Environmental Health Criteria 172, Geneva, Switzerland.
13. Jakobsson K., Thuresson K., Rylander L., Sjodin A., Hagmar L., and Bergman A. Exposure to polybrominated diphenyl ethers and tetrabromobisphenol A among computer technicians. Chemosphere 46 (2002) 709-716
14. Japanese Association for Laboratory Animal Science, 1987. Guideline for animal experimentation. Experimental Animals 23, pp. 285-288 (in Japanese).
15. Mariussen E., and Fonnum F. The effect of brominated flame retardants on neurotransmitter uptake into rat brain synaptosomes and vesicles. Neurochemistry International 43 (2003) 533-542
16. Meerts I.A., Assink Y., Cenijn P.H., Weijers B.M., Hans H.J., Bergman A., Koeman J.H., and Brouwer A. Distribution of the flame retardant tetrabromobisphenol A in pregnant and fetal rats and effect on thyroid hormone homeostasis. Organohalogen Compounds 40 (1999) 375-378
17. Meerts I.A., Letcher R.J., Hoving S., Marsh G., Bergman A., Lemmen J.G., van der Burg B., and Brouwer A. In vitro estrogenicity of polybrominated diphenyl ethers, hydroxylated PDBEs, and polybrominated bisphenol A compounds. Environmental Health Perspectives 109 (2001) 399-407
18. Noda T., Morita S., Ohgaki S., Shimizu M., and Yamada A. Safety evaluation of chemicals for use in house-hold products (VII) Teratological studies on tetrabromobisphenol A in rats. Annual Report of Osaka City Institute of Public Health and Environmental Sciences 48 (1985) 106-121
19. Öberg K., Warman K., and Öberg T. Distribution and levels of brominated flame retardants in sewage sludge. Chemosphere 48 (2002) 805-809
20. Olsen C.M., Meussen-Elholm E., Samuelsen M., Holme J.A., and Hongslo J.K. Effects of the environmental oestrogens bisphenol A, tetrachlorobisphenol A, tetrabromobisphenol A, 4-hydroxybiphenyl and 4,4′-dihydroxybiphenyl on oestrogen receptor binding, cell proliferation and regulation of oestrogen sensitive proteins in the human breast cancer cell line MCF-7. Pharmacology and Toxicology 92 (2003) 180-188
21. Osako M., Kim Y., and Sakai S. Leaching of brominates flame retardants in leachate from landfills in Japan. Chemosphere 57 (2004) 1571-1579
22. Pullen S., Boecker R., and Tiegs G. The flame retardants tetrabromobisphenol A and tetrabromobisphenol A-bisallylether suppress the induction of interleukin-2 receptor alpha chain (CD25) in murine splenocytes. Toxicology 184 (2003) 11-22
23. Ronisz D., Finne E.F., Karlsson H., and Förlin L. Effects of the brominated flame retardants hexabromocyclododecane (HBCDD), and tetrabromobisphenol A (TBBPA), on hepatic enzymes and other biomarkers in juvenile rainbow trout and feral eelpout. Aquatic Toxicology 69 (2004) 229-245
24. Samuelsen M., Olsen C., Holme J.A., Meussen-Elholm E., Bergmann A., and Hongslo J.K. Estrogen-like properties of brominated analogs of bisphenol A in the MCF-7 human breast cancer cell line. Cell Biology and Toxicology 17 (2001) 139-151
25. Sellström U., and Jansson B. Analysis of tetrabromobisphenol A in a product and environmental samples. Chemosphere 31 (1995) 3085-3092
26. Sjödin A., Carlsson H., Thuresson K., Sjölin S., Bergman Å., and Östman C. Flame retardants in indoor air at an electronics recycling plant and at other work environments. Environmental Science and Technology 35 (2001) 448-454
27. Szymanska J.A., Piotrowski J.K., and Frydrych B. Hepatotoxicity of tetrabromobisphenol-A: effects of repeated dosage in rats. Toxicology 142 (2000) 87-95
28. Thomsen C., Lundanes E., and Becher G. Brominated flame retardants in archived serum samples from Norway: a study on temporal trends and the role of age. Environmental Science and Technology 36 (2002) 1414-1418
29. Thomsen C., Leknes H., Lundanes E., and Becher G. A new method for determination of halogenated flame retardants in human milk using solid-phase extraction. Journal of Analytical Toxicology 26 (2002) 129-137
30. Watanabe I., Kashimoto T., and Tatsukawa R. Identification of the flame retardant tetrabromobisphenol-A in the river sediment and the mussel collected in Osaka. Bulletin of Environmental Contamination and Toxicology 31 (1983) 48-52