Comparison of in vivo and ex vivo [3H]flumazenil binding assays to determine occupancy at the benzodiazepine binding site of rat brain GABAA receptors

Neuropharmacology

Volumn 51, Issue 1, 2006, Pages 168-172

  Li, Jennifer ^a   Fish, Rebecca L ^a   Cook, Susan M ^a   Tattersall, Frederick D ^a   Atack, John R ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

Dissociation; Ex vivo binding; Flumazenil (Ro 15 1788); GABA; In vivo binding; Receptor occupancy

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; BENZODIAZEPINE; BRETAZENIL; FLUMAZENIL; RADIOLIGAND; TRACER; TRITIUM;

ACCURACY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING ASSAY; BRAIN HOMOGENATE; BRAIN REGION; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG BINDING SITE; INCUBATION TIME; KINETICS; MALE; METHODOLOGY; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; RECEPTOR OCCUPANCY;

ANIMALS; BINDING SITES; BRAIN; BRAIN CHEMISTRY; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUMAZENIL; GABA MODULATORS; MALE; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A;

EID: 33745202262     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2006.03.020     Document Type: Article

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