Ca2+-dependent maturation of subtilisin from a hyperthermophilic archaeon, Thermococcus kodakaraensis: The propeptide is a potent inhibitor of the mature domain but is not required for its folding

Applied and Environmental Microbiology

Volumn 72, Issue 6, 2006, Pages 4154-4162

  Pulido, Marian ^a   Saito, Kenji ^a   Tanaka, Shun Ichi ^a   Koga, Yuichi ^a   Morikawa, Masaaki ^a,c   Takano, Kazufumi ^a,b   Kanaya, Shigenori ^a  

^a OSAKA UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c HOKKAIDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CALCIUM; DEGRADATION; ENZYME INHIBITION; ESCHERICHIA COLI;

AUTOPROCESSING; T. KODAKARAENSIS MAT-SUBTILISIN MOLECULES; T. KODAKARAENSIS PROPEPTIDE;

POLYPEPTIDES;

CALCIUM; PEPTIDE; PROPEPTIDE; PROSUBTILISIN; PROTEIN INHIBITOR; PROTEIN PRECURSOR; SUBTILISIN; UNCLASSIFIED DRUG; ARCHAEAL PROTEIN; ENZYME PRECURSOR;

BIOCHEMISTRY; BIOLOGICAL ANALYSIS; CALCIUM; ENZYME; MATURATION; PEPTIDE; THERMOPHILIC BACTERIUM;

ARCHAEBACTERIUM; ARTICLE; ENZYME ACTIVITY; KINETICS; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN ANALYSIS; PROTEIN AUTOPROCESSING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN PROCESSING; PROTEIN PURIFICATION; PROTEIN STABILITY; PROTEIN SYNTHESIS; TEMPERATURE DEPENDENCE; THERMOCOCCUS; THERMOCOCCUS KODAKARAENSIS KOD1; THERMOPHILIC BACTERIUM; DRUG ANTAGONISM; ENZYMOLOGY; GROWTH, DEVELOPMENT AND AGING; HEAT; METABOLISM; MOLECULAR GENETICS; THERMODYNAMICS;

ARCHAEA; THERMOCOCCUS KODAKARENSIS;

ARCHAEAL PROTEINS; CALCIUM; ENZYME PRECURSORS; HEAT; KINETICS; MOLECULAR SEQUENCE DATA; PROTEIN FOLDING; SUBTILISINS; THERMOCOCCUS; THERMODYNAMICS;

EID: 33745182284     PISSN: 00992240     EISSN: None     Source Type: Journal    
DOI: 10.1128/AEM.02696-05     Document Type: Article

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