Determination of antifungal activities in serum samples from mice treated with different antifungal drugs allows detection of an active metabolite of itraconazole

Microbiology and Immunology

Volumn 50, Issue 4, 2006, Pages 281-292

  Maki, Katsuyuki ^a   Watabe, Etsuko ^a   Iguchi, Yumi ^a   Nakamura, Hideko ^a   Tomishima, Masaki ^a   Ohki, Hidenori ^a   Yamada, Akira ^a   Matsumoto, Satoru ^a   Ikeda, Fumiaki ^a   Tawara, Shuichi ^a   Mutoh, Seitaro ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

Active metabolite; Amphotericin B; Antifungal titer; Bioautography; Ex vivo; Itraconazole

Indexed keywords

AMPHOTERICIN B; AMPHOTERICIN B DEOXYCHOLATE; ANTIFUNGAL AGENT; DRUG METABOLITE; FLUCONAZOLE; ITRACONAZOLE;

ANIMAL EXPERIMENT; ANTIFUNGAL ACTIVITY; ARTICLE; ASPERGILLUS FUMIGATUS; CANDIDA ALBICANS; CONTROLLED STUDY; DRUG ABSORPTION; DRUG DETERMINATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MICROBIOLOGICAL EXAMINATION; MINIMUM INHIBITORY CONCENTRATION; MOUSE; MYCELIAL GROWTH; NONHUMAN; SERUM; ANIMAL; BIOTRANSFORMATION; BLOOD; DRUG EFFECT; INSTITUTE FOR CANCER RESEARCH MOUSE;

ASPERGILLUS FUMIGATUS; CANDIDA ALBICANS; MUS;

ANIMALS; ANTIFUNGAL AGENTS; ASPERGILLUS FUMIGATUS; BIOTRANSFORMATION; CANDIDA ALBICANS; ITRACONAZOLE; MALE; MICE; MICE, INBRED ICR; MICROBIAL SENSITIVITY TESTS;

EID: 33745164632     PISSN: 03855600     EISSN: 13480421     Source Type: Journal    
DOI: 10.1111/j.1348-0421.2006.tb03796.x     Document Type: Article

References (33)

1. Agarwal, A.K., Rogers, P.D., Baerson, S.R., Jacob, M.R., Barker, K.S., Cleary, J.D., Walker, L.A., Nagle, D.G., and Clark, A.M. 2003. Genome-wide expression profiling of the response to polyene, pyrimidine, azole, and echinocandin antifungal agents in Saccharomyces cerevisiae. J. Biol. Chem. 278: 34998-35015.
2. Bammert, G.F., and Fostel, J.M. 2000. Genome-wide expression patterns in Saccharomyces cerevisiae: comparison of drug treatments and genetic alterations affecting biosynthesis of ergosterol. Antimicrob. Agents Chemother. 44: 1255-1265.
3. Bartizal, C., and Odds, F.C. 2003. Influences of methodological variables on susceptibility testing of caspofungin against Candida species and Aspergillus fumigatus. Antimicrob. Agents Chemother. 47: 2100-2107.
4. Conte, J.E., Jr., Golden, J.A., Kipps, J., McIver, M., and Zurlinden, E. 2004. Intrapulmonary pharmacokinetics and pharmacodynamics of itraconazole and 14-hydroxyitraconazole at steady state. Antimicrob. Agents Chemother. 48: 3823-3827.
5. De Backer, M.D., Ilyina, T., Ma, X.-J., Vandoninck, S., Luyten, W.H.M.L., and Vanden Bossche, H. 2001. Genomic profiling of the response of Candida albicans to itraconazole treatment using a DNA microarray. Antimicrob. Agents Chemother. 45: 1660-1670.
6. Denning, D.W. 2003. Echinocandin antifungal drugs. Lancet 362:1142-1151.
7. Henry, K.W., Nickels, J.T., and Edlind, T.D. 2000. Upregulation of ERG genes in Candida species by azoles and other sterol biosynthesis inhibitors. Antimicrob. Agents Chemother. 44: 2693-2700.
8. Heykants, J., Van Peer, A., Van de Velde, V., Van Rooy, P., Meuldermans, W., Lavrijsen, K., Woestenborghs, R., Van Cutsem, J., and Cauwenbergh, G. 1989. The clinical pharmacokinetics of itraconazole: an overview. Mycoses 32 (Suppl 1): 67-87.
9. Hostetler, J.S., Heykants, J., Clemons, K.V., Woestenborghs, R., Hanson, L.H., and Stevens, D.A. 1993. Discrepancies in bioassay and chromatography determinations explained by metabolism of itraconazole to hydroxyitraconazole: studies of interpatient variations in concentrations. Antimicrob. Agents Chemother. 37: 2224-2227.
10. Imhof, A., Balajee, S.A., and Marr, K.A. 2003. New methods to assess susceptibilities of Aspergillus isolates to caspofungin. J. Clin. Microbiol. 41: 5683-5688.
11. Inagaki, K., Takagi, J., Lor, E., Okamoto, M. P., and Gill, M. A. 1992. Determination of fluconazole in human serum by solid-phase extraction and reversed-phase high-performance liquid chromatography. Ther. Drug Monit. 14: 306-311.
12. Jain, P., Akula, I., and Edlind, T. 2003. Cyclic AMP signaling pathway modulates susceptibility of Candida species and Saccharomyces cerevisiae to antifungal azoles and other sterol biosynthesis inhibitors. Antimicrob. Agents Chemother. 47: 3195-3201.
13. Law, D., Moore, C.B., and Denning, D.W. 1994. Bioassay for serum itraconazole concentrations using hydroxyitraconazole standards. Antimicrob. Agents Chemother. 38: 1561-1566.
14. Maertens, J.A. 2004. History of the development of azole derivatives. Clin. Microbiol. Infect. 10 (Suppl 1): 1-10.
15. National Committee for Clinical Laboratory Standards. 2002. Reference method for broth dilution antifungal susceptibility testing of yeasts; approved standard, NCCLS document M27-A2, National Committee for Clinical Laboratory Standards, Wayne, Pa.
16. National Committee for Clinical Laboratory Standards. 2002. Reference method for broth dilution antifungal susceptibility testing of filamentous fungi. Approved standard M38-A, National Committee for Clinical Laboratory Standards, Wayne, Pa.
17. Nilsson-Ehle, I., Yoshikawa, T.T., Edwards, J.E., Schotz, M.C., and Guze, L.B. 1977. Quantitation of amphotericin B with use of high-pressure liquid chromatography. J. Infect. Dis. 135: 414-422.
18. Odds, F.C., Cockayne, A., Hayward, J., and Abbott, A.B. 1985. Effects of imidazole- and triazole-derivative antifungal compounds on the growth and morphological development of Candida albicans hyphae. J. Gen. Microbiol. 131: 2581-2589.
19. Pfaller, M.A., Rex, J.H., and Rinaldi, M.G. 1997. Antifungal susceptibility testing: technical advances and potential clinical applications. Clin. Infect. Dis. 24: 776-784.
20. Rambali, B., Fernandez, J.A., Van Nuffel, L., Woestenborghs, F., Baert, L., Massart, D.L., and Odds, F.C. 2001. Susceptibility testing of pathogenic fungi with itraconazole: a process analysis of test variables. J. Antimicrob. Chemother. 48: 163-177.
21. Rex, J.H., Pfaller, M.A., Rinaldi, M.G., Polak, A., and Galgiani, J.N. 1993. Antifungal susceptibility testing. Clin. Microbiol. Rev. 6: 367-381.
22. Rex, J.H., Pfaller, M.A., Walsh, T.J., Chaturvedi, V., Espinel-Ingroff, A., Ghannoum, M.A., Gosey, L.L., Odds, F.C., Rinaldi, M.G., Sheehan, D.J., and Warnock, D.W. 2001. Antifungal susceptibility testing: practical aspects and current challenges. Clin. Microbiol. Rev. 14: 643-658.
23. Reynes, J., Bazin, C., Ajana, F., Datry, A., Le Moing, J.P., Chwetzoff, E., and Levron, J.C. 1997. Pharmacokinetics of itraconazole (oral solution) in two groups of human immunodeficiency virus-infected adults with oral candidiasis. Antimicrob. Agents Chemother. 41: 2554-2558.
24. Sakamoto, H., Hirose, T., Nakamoto, S., Hatano, K., Shibayama, F., Kikuchi, H., Mine, Y., and Kuwahara, S. 1988. Pharmacokinetics of FK482, a new orally active cephalosporin, in animals. J. Antibiot. 41: 1896-1905.
25. Saville, S.P., Lazzell, A.L., Monteagudo, C., and Lopez-Ribot, J.L. 2003. Engineered control of cell morphology in vivo reveals distinct roles for yeast and filamentous forms of Candida albicans during infection. Eukaryot. Cell 2: 1053-1060.
26. Te Dorsthorst, D.T., Mouton, J.W., van den Beukel, C.J., van der Lee, H.A., Meis, J.F., and Verweij, P.E. 2004. Effect of pH on the in vitro activities of amphotericin B, itraconazole, and flucytosine against Aspergillus isolates. Antimicrob. Agents Chemother. 48: 3147-3150.
27. Tkacz, J.S., and DiDomenico, B. 2001. Antifungals: what's in the pipeline. Curr. Opin. Microbiol. 4: 540-545.
28. Wakabayashi, H., Abe, S., Teraguchi, S., Hayasawa, H., and Yamaguchi, H. 1998. Inhibition of hyphal growth of azole-resistant strains of Candida albicans by triazole antifungal agents in the presence of lactoferrin-related compounds. Antimicrob. Agents Chemother. 42: 1587-1591.
29. Warn, P.A., Sharp, A., Guinea, J., and Denning, D.W. 2004. Effect of hypoxic conditions on in vitro susceptibility testing of amphotericin B, itraconazole and micafungin against Aspergillus and Candida. J. Antimicrob. Chemother. 53: 743-749.
30. Warnock, D.W., Turner, A., and Burke, J. 1988. Comparison of high performance liquid chromatographic and microbiological methods for determination of itraconazole. J. Antimicrob. Chemother. 21: 93-100.
31. Wong, J.W., Nisar, U.R., and Yuen, K.H. 2003. Liquid chromatographic method for the determination of plasma itraconazole and its hydroxy metabolite in pharmacokinetic/bioavailability studies. J. Chromatogr. B 798: 355-360.
32. Yamaguchi, H., Uchida, K., Nagino, K., and Matsunaga, T. 2002. Usefulness of a colorimetric method for testing antifungal drug susceptibilities of Aspergillus species to voriconazole. J. Infect. Chemother. 8: 374-377.
33. Zhang, L., Zhang, Y., Zhou, Y., An, S., Zhou, Y., and Cheng, J. 2002. Response of gene expression in Saccharomyces cerevisiae to amphotericin B and nystatin measured by microarrays. J. Antimicrob. Chemother. 49: 905-915.