Synthesis and biological evaluation of novel heterocyclic ionone-like derivatives as anti-inflammatory agents

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 15, 2006, Pages 5152-5160

  Balbi, Alessandro ^a   Anzaldi, Maria ^a   Mazzei, Mauro ^a   Miele, Mariangela ^a   Bertolotto, Maria ^a   Ottonello, Luciano ^a   Dallegri, Franco ^a  

^a UNIVERSITY OF GENOA   (Italy)

Author keywords

Antiinflammatory activity; Isoxazole; Neutrophil chemotaxis; Neutrophil superoxide; Pyrazole; Pyrimidine ionone like derivatives

Indexed keywords

1 (2 CHLOROPHENYL) 5 (2,6,6 TRIMETHYL 2 CYCLOHEX 1 YL)ETHENYL 1H PYRAZOLE; 1 (2,4 NITROPHENYL) 5 (2,6,6 TRIMETHYL 2 CYCLOHEX 1 YL)ETHENYL 1H PYRAZOLE; 1 (4 BROMOPHENYL) 5 (2,6,6 TRIMETHYL 2 CYCLOHEX 1 YL)ETHENYL 1H PYRAZOLE; 1 (4 CHLOROPHENYL) 5 (2,6,6 TRIMETHYL 2 CYCLOHEX 1 YL)ETHENYL 1H PYRAZOLE; 1 PHENYL 5 (2,6,6 TRIMETHYL 2 CYCLOHEX 1 YL)ETHENYL 1H PYRAZOLE; 2 [5 [2 (2,6,6 TRIMETHYL 2 CYCLOHEXEN 1 YL)ETHENYL] 1H PYRAZOL 1 YL]ETHANOL; 2 METHYLTHIO 4 [(2,6,6 TRIMETHYL 2 CYCLOHEXEN 1 YL)ETHENYL]PYRIMIDINE; 4 AMINO 5 [5 [2 (2,6,6 TRIMETHYL 2 CYCLOHEXEN 1 YL)ETHENYL]PYRAZOL 1 YL 4H [1,2,4]TRIAZOLE 3 THIOL; 5 (2,6,6 TRIMETHYL 2 CYCLOHEXEN 1 YL)ETHENYL 1H PYRAZOLE; 5 (2,6,6 TRIMETHYL 2 CYCLOHEXEN 1 YL)ETHENYLISOXAZOLE; 6 (2,6,6 TRIMETHYL 2 CYCLOHEXEN 1 YL)ETHENYL 2 AMINOPYRIMIDINE; ANTIINFLAMMATORY AGENT; IONONE DERIVATIVE; N,N DIMETHYL 5 [(2,6,6 TRIMETHYL 2 CYCLOHEXEN 1 YL)ETHENYL] 1H PYRAZOLE 1 CARBOTHIOAMIDE; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL MIGRATION; CELL VIABILITY; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NORMAL HUMAN; PSORIASIS; RESPIRATORY BURST; SKIN DISEASE;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL MOVEMENT; CELL SURVIVAL; CHEMOTAXIS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HUMANS; NEUTROPHILS; NORISOPRENOIDS; RESPIRATORY BURST; STRUCTURE-ACTIVITY RELATIONSHIP; SUPEROXIDES;

EID: 33745159027     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.04.007     Document Type: Article

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