Anabolic responsiveness of skeletal muscles correlates with androgen receptor protein but not mRNA

Canadian Journal of Physiology and Pharmacology

Volumn 84, Issue 2, 2006, Pages 273-277

  Monks, Douglas A ^a   Kopachik, Will ^b   Breedlove, S Marc ^b   Jordan, Cynthia L ^b  

^a UNIVERSITY OF TORONTO   (Canada)

^b MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

Anabolic steroids; Extensor digitorum longus; Levator ani; Sexual dimorphism; Spinal nucleus of the bulbocavernosus; Testosterone

Indexed keywords

ANDROGEN RECEPTOR; MESSENGER RNA;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; EXTENSOR DIGITORUM LONGUS MUSCLE; LEVATOR ANI MUSCLE; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKELETAL MUSCLE; WESTERN BLOTTING;

ANABOLIC AGENTS; ANDROGENS; ANIMALS; MALE; MUSCLE, SKELETAL; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ANDROGEN; RNA, MESSENGER;

EID: 33745150050     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/y05-157     Document Type: Article

References (17)

1. Antonio, J., Wilson, J.D., and George, F.W. 1999. Effects of castration and androgen treatment on androgen-receptor levels in rat skeletal muscles. J. Appl. Physiol. 87: 2016-2019. PMID: 10601143.
2. Blok, L.J., de Ruiter, P.E., and Brinkmann, A.O. 1996. Androgen receptor phosphorylation. Endocr. Res. 22: 197-219. PMID: 8875135.
3. Breedlove, S.M., and Arnold, A.P. 1980. Hormone accumulation in a sexually dimorphic motor nucleus of the rat spinal cord. Science, 210: 564-566. PMID: 7423210.
4. Edgerton, V.R., and Simpson, D.R. 1971. Dynamic and metabolic relationships in the rat extensor digitorum longus muscle. Exp. Neurol. 30: 374-376. PMID: 4251154.
5. Hanzlikova, V., Schiaffino, S., and Settembrini, P. 1970. Histochemical fiber types characteristics in the normal and the persistent levator ani muscle of the rat. Histochemie, 22: 45-50. PMID: 4245675.
6. Hart, B.L. 1983. Role of testosterone secretion and penile reflexes in sexual behavior and sperm competition in male rats: a theoretical contribution. Physiol. Behav. 31: 823-827. doi:10.1016/0031-9384(83)90279-2. PMID: 6665072.
7. Lin, H.K., Wang, L., Hu, Y.C., Altuwaijri, S., and Chang, C. 2002. Phosphorylation-dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase. EMBO J. 21: 4037-4048. doi:10.1093/emboj/cdf406. PMID: 12145204.
8. Lubischer, J.L., and Bebinger, D.M. 1999. Regulation of terminal Schwann cell number at the adult neuromuscular junction. J. Neurosci. 19: RC46. PMID: 10594090.
9. Monks, D.A., Getsios, S., MacCalman, C.D., and Watson, N.V. 2001. N-cadherin is regulated by gonadal steroids in the adult hippocampus. Proc. Natl. Acad. Sci. USA, 98: 1312-1316. doi:10.1073/pnas.031562798. PMID: 11158636.
10. Monks, D.A., O'Bryant, E.L., and Jordan, C.L. 2004. Androgen receptor immunoreactivity in skeletal muscle: enrichment at the neuromuscular junction. J. Comp. Neurol. 473: 59-72. doi:10. 1002/cne.20088. PMID: 15067718.
11. Mora, G.R., and Mahesh, V.B. 1999. Autoregulation of the androgen receptor at the translational level: testosterone induces accumulation of androgen receptor mRNA in the rat ventral prostate polyribosomes. Steroids, 64: 587-591. doi:10.1016/S0039-128X(99)00037-9. PMID: 10503713.
12. Mora, G.R., Prins, G.S., and Mahesh, V.B. 1996. Autoregulation of androgen receptor protein and messenger RNA in rat ventral prostate is protein synthesis dependent. J. Steroid Biochem. Mol. Biol. 58: 539-549. doi: 10.1016/0960-0760(96)00079-9. PMID: 8918980.
13. O'Hanlon, J.K., and Sachs, B.D. 1986. Fertility of mating in rats (Rattus norvegicus): contributions of androgen-dependent morphology and actions of the penis. J. Comp. Psychol. 100: 178-187. doi:10.1037/0735-7036.100.2.178. PMID: 3755090.
14. Prins, G.S., Birch, L., and Greene, G.L. 1991. Androgen receptor localization in different cell types of the adult rat prostate. Endocrinology, 129: 3187-3199. PMID: 1954898.
15. Rance, N.B., and Max, S.R. 1984. Modulation of the cytosolic androgen receptor in striated muscle by sex steroids. Endocrinology, 115: 862-866. PMID: 6611254.
16. Tan, J.A., Joseph, D.R., Quarmby, V.E., Lubahn, D.B., Sar, M., French, F.S., and Wilson, E.M. 1988. The rat androgen receptor: primary structure, autoregulation of its messenger ribonucleic acid, and immunocytochemical localization of the receptor protein. Mol. Endocrinol. 2: 1276-1285. PMID: 3216867.
17. Woodham, C., Birch, L., and Prins, G.S. 2003. Neonatal estrogen down-regulates prostatic androgen receptor through a proteosome-mediated protein degradation pathway. Endocrinology, 144: 4841-4850. doi:10.1210/en.2003-0035. PMID: 12960060.