Promoter hypermethylation and global hypomethylation are independent epigenetic events in lymphoid leukemogenesis with opposing effects on clinical outcome [5]

Leukemia

Volumn 20, Issue 8, 2006, Pages 1445-1448

  Roman Gomez, J ^a   Jimenez Velasco, A ^b   Agirre, X ^c   Castillejo, J A ^a   Navarro, G ^b   Garate, L ^c   San Jose Eneriz, E ^c   Cordeu, L ^c   Barrios, M ^b   Prosper, F ^c   Heiniger, A ^b   Torres, A ^a  

^a HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

^b HOSPITAL REGIONAL UNIVERSITARIO DE MÁLAGA   (Spain)

^c UNIVERSITY CLINIC OF NAVARRA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; TUMOR SUPPRESSOR PROTEIN;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; APOPTOSIS; CELL ADHESION; CELL CYCLE; CHILD; CONTROLLED STUDY; DNA METHYLATION; DOWN REGULATION; EPIGENETICS; FEMALE; GENE FREQUENCY; HUMAN; LETTER; LEUKEMIA RELAPSE; LEUKEMOGENESIS; MAJOR CLINICAL STUDY; MALE; METASTASIS; MOLECULAR DYNAMICS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROGNOSIS; PROMOTER REGION; SIGNAL TRANSDUCTION;

EID: 33745125112     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/sj.leu.2404257     Document Type: Letter

References (8)

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4. Roman-Gomez J, Jimenez-Velasco A, Agirre X, Prosper F, Heiniger A, Torres A. Lack of CpG island methylator phenotype defines a clinical subtype of T-cell acute lymphoblastic leukemia associated with good prognosis. J Clin Oncol 2005; 23: 7043-7049.
5. Roman-Gomez J, Jimenez-Velasco A, Agirre X, Cervantes F, Sanchez J, Garate L et al. Promoter hypomethylation of the LINE-1 retrotransposable elements activates sense/antisense transcription and marks the progression of chronic myeloid leukemia. Oncogene 2005; 24: 7213-7223.
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8. Yamada Y, Jackson-Grusby L, Linhart H, Meissner A, Eden A, Lin H et al. Opposing effects of DNA hypomethylation on intestinal and liver carcinogenesis. Proc Natl Acad Sci USA 2005; 102: 13580-13585.