Cytosolic phospholipase A2: Biochemical properties and physiological roles

IUBMB Life

Volumn 58, Issue 5-6, 2006, Pages 328-333

  Shimizu, Takao ^a   Ohto, Takayo ^a   Kita, Yoshihiro ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

cPLA2 ; Lipid mediators; Phospholipase A2

Indexed keywords

ACYL COENZYME A; ACYLTRANSFERASE; FATTY ACID DERIVATIVE; GLYCEROPHOSPHOLIPID; ICOSANOID; ISOENZYME; LIPOPROTEIN; LUNG SURFACTANT; LYSOPHOSPHOLIPID; LYSOPHOSPHOLIPID ACYLTRANSFERASE; MEMBRANE LIPID; PHOSPHATIDYLCHOLINE; PHOSPHOLIPASE A2; UNCLASSIFIED DRUG; PHOSPHOLIPASE A; PHOSPHOLIPASE A2 ALPHA; PHOSPHOLIPASE A2-ALPHA;

BIOCHEMISTRY; CATALYSIS; CONFERENCE PAPER; CYTOSOL; DEACYLATION; ENZYME ACTIVITY; GENETIC MANIPULATION; LIPID COMPOSITION; LIPID MEMBRANE; LIQUID CHROMATOGRAPHY; MEDIATOR; NONHUMAN; PATHOLOGY; PHENOTYPE; PHYSIOLOGY; PROTEIN FAMILY; PROTEIN FUNCTION; SERUM; STIMULATION; TANDEM MASS SPECTROMETRY; ANIMAL; CHEMISTRY; ENZYMOLOGY; GENETICS; HUMAN; MULTIGENE FAMILY; REVIEW;

ANIMALS; CYTOSOL; HUMANS; ISOENZYMES; MULTIGENE FAMILY; PHOSPHOLIPASES A;

EID: 33745098383     PISSN: 15216543     EISSN: 15216551     Source Type: Journal    
DOI: 10.1080/15216540600702289     Document Type: Conference Paper

References (38)

1. Narumiya, S., and FitzGerald, G. A. (2001) Genetic and pharmacological analysis of prostanoid receptor function. J. Clin. Invest. 108, 25-30 .
2. Narumiya, S., Sugimoto, Y., and Ushikubi, F. (1999) Prostanoid receptors: structures, properties, and functions. Physiol. Rev. 79, 1193-1226.
3. Spiegel, S., and Milstien, S. (2002) Sphingosine 1-phosphate, a key cell signaling molecule. J. Biol. Chem. 277, 25851-25854.
4. Ishii, S., and Shimizu, T. (2000) Platelet-activating factor (PAF) receptor and genetically engineered PAF receptor mutant mice. Prog. Lipid Res. 39, 41-82.
5. Ishii, I., Fukushima, N., Ye, X., and Chun, J. (2004) Lysophospholipid receptors: signaling and biology. Annu. Rev. Biochem. 73, 321-354.
6. Hla, T., Lee, M. J., Ancellin, N., Paik, J. H., and Kluk, M. J. (2001) Lysophospholipids - receptor revelations. Science 294, 1875-1878.
7. McPartland, J. M., Matias, I., Dimarzo, V., and Glass, M. (2006) Evolutionary origins of the endocannabinoid system. Gene 370, 64-74.
8. Dennis, E. A. (1997) The growing phospholipase A2 superfamily of signal transduction enzymes. Trends Biochem. Sci. 22, 1-2.
9. Uozumi, N., Kume, K., Nagase, T., Nakatani, N., Ishii, S., Tashiro, F., Komagata, Y., Maki, K., Ikuta, K., Ouchi, Y., Miyazaki, J., and Shimizu, T. (1997) Role of cytosolic phospholipase A2 in allergic response and parturition. Nature 390, 618-622.
10. Bonventre, J. V., Huang, Z., Taheri, M. R., O'Leary, E., Li, E., Moskowitz, M. A., and Sapirstein, A. (1997) Reduced fertility and postischaemic brain injury in mice deficient in cytosolic phospholipase A2. Nature 390, 622-625.
11. Ohto, T., Uozumi, N., Hirabayashi, T., and Shimizu, T. (2005) Identification of novel cytosolic phospholipase A(2)s, murine cPLA(2){delta}, {epsilon}, and {zeta}, which form a gene cluster with cPLA(2){beta}. J. Biol. Chem. 280, 24576-24583.
12. Dennis, E. A. (2000) Phospholipase A2 in eicosanoid generation. Am. J. Respir. Crit. Care Med. 161, S32-35.
13. Clark, J. D., Milona, N., and Knopf, J. L. (1990) Purification of a 110-kilodalton cytosolic phospholipase A2 from the human monocytic cell line U937. Proc. Natl. Acad. Sci. USA 87, 7708-7712.
14. Clark, J. D., Lin, L. L., Kriz, R. W., Ramesha, C. S., Sultzman, L. A., Lin, A. Y., Milona, N., and Knopf, J. L. (1991) A novel arachidonic acid-selective cytosolic PLA2 contains a Ca(2+)-dependent translocation domain with homology to PKC and GAP. Cell 65, 1043-1051.
15. Sharp, J. D., White, D. L., Chiou, X. G., Goodson, T., Gamboa, G. C., McClure, D., Burgett, S., Hoskins, J., Skatrud, P. L., Sportsman, J. R., et al. (1991) Molecular cloning and expression of human Ca(2+)-sensitive cytosolic phospholipase A2. J. Biol. Chem. 266, 14850-14853.
16. Sugimoto, Y., Segi, E., Tsuboi, K., Ichikawa, A., and Narumiya, S. (1998) Female reproduction in mice lacking the prostaglandin F receptor. Roles of prostaglandin and oxytocin receptors in parturition. Adv. Exp. Med. Biol. 449, 317-321.
17. Kita, Y., Takahashi, T., Uozumi, N., and Shimizu, T. (2005) A multiplex quantitation method for eicosanoids and platelet-activating factor using column-switching reversed-phase liquid chromatography-tandem mass spectrometry. Anal. Biochem. 342, 134-143.
18. Kita, Y., Takahashi, T., Uozumi, N., Nallan, L., Gelb, M. H., and Shimizu, T. (2005) Pathway-oriented profiling of lipid mediators in macrophages. Biochem. Biophys. Res. Commun. 330, 898-906.
19. Kihara, Y., Ishii, S., Kita, Y., Toda, A., Shimada, A., and Shimizu, T. (2005) Dual phase regulation of experimental allergic encephalomyelitis by platelet-activating factor. J. Exp. Med. 202, 853-863.
20. Dessen, A., Tang, J., Schmidt, H., Stahl, M., Clark, J. D., Seehra, J., and Somers, W. S. (1999) Crystal structure of human cytosolic phospholipase A2 reveals a novel topology and catalytic mechanism. Cell 97, 349-360.
21. Glover, S., de Carvalho, M. S., Bayburt, T., Jonas, M., Chi, E., Leslie, C. C., and Gelb, M. H. (1995) Translocation of the 85-kDa phospholipase A2 from cytosol to the nuclear envelope in rat basophilic leukemia cells stimulated with calcium ionophore or IgE/antigen. J. Biol. Chem. 270, 15359-15367.
22. Hirabayashi, T., Kume, K., Hirose, K., Yokomizo, T., Iino, M., Itoh, H., and Shimizu, T. (1999) Critical duration of intracellular Ca2+ response required for continuous translocation and activation of cytosolic phospholipase A2. J. Biol. Chem. 274, 5163-5169.
23. Song, H., Lim, H., Paria, B. C., Matsumoto, H., Swift, L. L., Morrow, J., Bonventre, J. V., and Dey, S. K. (2002) Cytosolic phospholipase A2alpha is crucial for 'on-time' embryo implantation that directs subsequent development. Development 129, 2879-2889.
24. Downey, P., Sapirstein, A., O'Leary, E., Sun, T. X., Brown, D., and Bonventre, J. V. (2001) Renal concentrating defect in mice lacking group IV cytosolic phospholipase A(2). Am. J. Physiol. Renal Physiol. 280, F607-618.
25. Bonventre, J. (2004) Cytosolic phospholipase A2alpha reigns supreme in arthritis and bone resorption. Trends Immunol. 25, 116-119.
26. Tabuchi, S., Uozumi, N., Ishii, S., Shimizu, Y., Watanabe, T., and Shimizu, T. (2003) Mice deficient in cytosolic phospholipase A2 are less susceptible to cerebral ischemia/reperfusion injury. Acta Neurochir. Suppl. 86, 169-172.
27. Fujishima, H., Sanchez Mejia, R. O., Bingham, C. O., 3rd, Lam, B. K., Sapirstein, A., Bonventre, J. V., Austen, K. F., and Arm, J. P. (1999) Cytosolic phospholipase A2 is essential for both the immediate and the delayed phases of eicosanoid generation in mouse bone marrow-derived mast cells. Proc. Natl. Acad. Sci. USA 96, 4803-4807.
28. Nakatani, N., Uozumi, N., Kume, K., Murakami, M., Kudo, I., and Shimizu, T. (2000) Role of cytosolic phospholipase A2 in the production of lipid mediators and histamine release in mouse bone-marrow-derived mast cells. Biochem. J. 352 Pt 2, 311-317.
29. Nagase, T., Uozumi, N., Ishii, S., Kume, K., Izumi, T., Ouchi, Y., and Shimizu, T. (2000) Acute lung injury by sepsis and acid aspiration: a key role for cytosolic phospholipase A2. Nat. Immunol. 1, 42-46.
30. Nagase, T., Uozumi, N., Aoki-Nagase, T., Terawaki, K., Ishii, S., Tomita, T., Yamamoto, H., Hashizume, K., Ouchi, Y., and Shimizu, T. (2003) A potent inhibitor of cytosolic phospholipase A2, arachidonyl trifluoromethyl ketone, attenuates LPS-induced lung injury in mice. Am. J. Physiol. Lung Cell Mol. Physiol. 284, L720-726.
31. Nagase, T., Uozumi, N., Ishii, S., Kita, Y., Yamamoto, H., Ohga, E., Ouchi, Y., and Shimizu, T. (2002) A pivotal role of cytosolic phospholipase A(2) in bleomycin-induced pulmonary fibrosis. Nat. Med. 8, 480-484.
32. Hegen, M., Sun, L., Uozumi, N., Kume, K., Goad, M. E., Nickerson-Nutter, C. L., Shimizu, T., and Clark, J. D. (2003) Cytosolic phospholipase A2alpha-deficient mice are resistant to collagen-induced arthritis. J. Exp. Med. 197, 1297-1302.
33. Miyaura, C., Inada, M., Matsumoto, C., Ohshiba, T., Uozumi, N., Shimizu, T., and Ito, A. (2003) An essential role of cytosolic phospholipase A2alpha in prostaglandin E2-mediated bone resorption associated with inflammation. J. Exp. Med. 197, 1303-1310.
34. Klivenyi, P., Beal, M. F., Ferrante, R. J., Andreassen, O. A., Wermer, M., Chin, M. R., and Bonventre, J. V. (1998) Mice deficient in group IV cytosolic phospholipase A2 are resistant to MPTP neurotoxicity. J. Neurochem. 71, 2634-2637.
35. Takaku, K., Sonoshita, M., Sasaki, N., Uozumi, N., Doi, Y., Shimizu, T., and Taketo, M. M. (2000) Suppression of intestinal polyposis in Apc(delta 716) knockout mice by an additional mutation in the cytosolic phospholipase A(2) gene. J. Biol. Chem. 275, 34013-34016.
36. Marusic, S., Leach, M. W., Pelker, J. W., Azoitei, M. L., Uozumi, N., Cui, J., Shen, M. W., DeClercq, C. M., Miyashiro, J. S., Carito, B. A., Thakker, P., Simmons, D. L., Leonard, J. P., Shimizu, T., and Clark, J. D. (2005) Cytosolic phospholipase A2 alpha-deficient mice are resistant to experimental autoimmune encephalomyelitis. J. Exp. Med. 202, 841-851.
37. Yoshikawa, K., Kita, Y., Kishomoto, K., Shimada, A., and Shimizu, T. (2006) Profiling of eicosanoid production in the rat hippocampus during kainate-induced seizure: dual phase regulation and differential involvement of Cox-1 and Cox-2. J. Biol. Chem. 281, in press.
38. Oikawa, Y., Yamato, E., Tashiro, F., Yamamoto, M., Uozumi, N., Shimada, A., Shimizu, T., and Miyazaki, J. (2005) Protective role for cytosolic phospholipase A2a in autoimmune diabetes of mice. FEBS Lett. 579, 3975-3978.