Identification of physical-chemical variables affecting particle size following precipitation using a supercritical fluid

Pharmaceutical Development and Technology

Volumn 11, Issue 2, 2006, Pages 195-205

  Sacha, Gregory ^a   Schmitt, William ^b   Nail, Steven ^a,c  

^a PURDUE UNIVERSITY   (United States)

^b PFIZER INC   (United States)

^c ELI LILLY AND COMPANY   (United States)

Author keywords

Crystallization; Precipitation; Steroid; Supercritical antisolvent

Indexed keywords

HEMISUCCINATE; HYDROCORTISONE ACETATE; HYDROCORTISONE SODIUM SUCCINATE; METHYLPREDNISOLONE; METHYLPREDNISOLONE ACETATE; PREDNISOLONE; PREDNISOLONE ACETATE; PREDNISOLONE HEMISUCCINATE; STEROID; UNCLASSIFIED DRUG; YTTRIUM;

ARTICLE; CRYSTALLIZATION; DIELECTRIC CONSTANT; DRUG SOLUBILITY; HYDRATION; PARTICLE SIZE; PHYSICAL CHEMISTRY; POWDER; PRECIPITATION; PRESSURE; PRIORITY JOURNAL; SOLUTE; SUPERCRITICAL FLUID; VAPOR PRESSURE;

CHEMISTRY, PHYSICAL; DRUG CARRIERS; DRUG COMPOUNDING; ELECTROCHEMISTRY; LASERS; LIGHT; MICROSCOPY, ELECTRON, SCANNING; PARTICLE SIZE; SCATTERING, RADIATION; SOLVENTS; STEROIDS; X-RAY DIFFRACTION;

EID: 33745087809     PISSN: 10837450     EISSN: 10979867     Source Type: Journal    
DOI: 10.1080/10837450600561299     Document Type: Article

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