The influence of fractionated radiation therapy on plasma vascular endothelial growth factor (VEGF) concentration in dogs with spontaneous tumors and its impact on outcome

Radiotherapy and Oncology

Volumn 79, Issue 2, 2006, Pages 239-244

  Wergin, Melanie C ^a   Roos, Malgorzata ^b   Inteeworn, Nathalie ^a   Laluhovà, Dagmar ^a   Allemann, Katrin ^a   Kaser Hotz, Barbara ^a  

^a VETSUISSE FACULTY UNIVERSITY OF ZURICH   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Canine; Plasma VEGF; Radiation; Survival; Time to treatment failure

Indexed keywords

VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD SAMPLING; CANCER PALLIATIVE THERAPY; CANCER RADIOTHERAPY; CANCER SURVIVAL; CONTROLLED STUDY; DOG; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FOLLOW UP; IONIZING RADIATION; LOW ENERGY RADIATION; MALE; NONHUMAN; OUTCOME ASSESSMENT; PREDICTION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION; QUANTITATIVE ANALYSIS; RADIATION DOSE; RADIATION DOSE FRACTIONATION; TIME; TREATMENT FAILURE; TREATMENT OUTCOME; TUMOR;

ANIMALS; DOG DISEASES; DOGS; DOSE FRACTIONATION; FEMALE; MALE; NEOPLASMS; SURVIVAL ANALYSIS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 33745071172     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.radonc.2006.03.021     Document Type: Article

References (33)

1. Achermann R.E., Ohlerth S.M., Rohrer-Bley C., et al. Oxygenation of spontaneous canine tumors during fractionated radiation therapy. Strahlenther Onkol 180 (2004) 1-9
2. Ando S., Nojima K., Majima H., et al. Evidence for mRNA expression of vascular endothelial growth factor by X-ray irradiation in a lung squamous carcinoma cell line. Cancer Lett 132 (1998) 75-80
3. Becker A., Stadler P., Krause U., et al. Association between elevated serum VEGF and polarographically measured tumor hypoxia in head and neck carcinomas. Strahlenther Onkol 177 (2001) 182-188
4. Carter S., Auer K.L., Reardon D.B., et al. Inhibition of the mitogen activated protein (MAP) kinase cascade potentiates cell killing by low dose ionizing radiation in A431 human squamous carcinoma cells. Oncogene 16 (1998) 2787-2796
5. Chin K.F., Greenman J., Reusch P., Gardiner E., Marme D., and Monson J.R. Vascular endothelial growth factor and soluble Tie-2 receptor in colorectal cancer: associations with disease recurrence. Eur J Surg Oncol 29 (2003) 497-505
6. Clifford C.A., Hughes D., Beal M.W., et al. Plasma vascular endothelial growth factor concentrations in healthy dog and dogs with hemangiosarcoma. J Vet Intern Med 14 (2001) 131-135
7. Clifford C.A., Hughes D., Beal M.W., et al. Vascular growth factor concentrations in body cavity effusions in dogs. J Vet Intern Med 16 (2002) 164-168
8. Couvelard A., O'Toole D., Turley H., et al. Microvessel density and hypoxia-inducible factor pathway in pancreatic endocrine tumors: negative correlation of microvascular density and VEGF expression with tumor progression. Br J Cancer 92 (2005) 94-101
9. Dent P., Reardon D.B., Park J.S., et al. Radiation-induced release of transforming growth factor α activates the epidermal growth factor receptor and mitogen-activated protein kinase pathway in carcinoma cells, leading to increased proliferation and protection from radiation induced cell death. Mol Biol Cell 10 (1999) 2493-2506
10. Dittadi R., Meo S., Fabris F., et al. Validation of blood collection procedures for the determination of circulating vascular endothelial growth factor (VEGF) in different blood compartments. Int J Biol Markers 16 (2001) 87-96
11. Dunst J., Stadler P., Becker A., et al. Tumor hypoxia and systemic levels of vascular endothelial growth factor (VEGF) in head and neck cancers. Strahlenther Onkol 177 (2001) 469-473
12. Ferrara N., and Davis-Smyth T. The biology of vascular endothelial growth factor. Endocr Rev 18 (1997) 4-18
13. Goldman C.K., Kendall R.L., Cabrera G., et al. Paracrine expression of a native soluble vascular endothelial growth factor receptor inhibits tumor growth, metastasis, and mortality rate. Proc Natl Acad Sci USA 95 (1998) 8795-8800
14. Gorski D.H., Beckett M.A., Jaskowiak N.T., et al. Blockage of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation. Cancer Res 59 (1999) 3374-3378
15. Hefler L., Tempfer C., Obermair A., et al. Serum concentrations of vascular endothelial growth factor in vulvar cancer. Clin Cancer Res 5 (1999) 2806-2809
16. Hormbrey E., Han C., Roberts A., McGrouther D.A., and Harris A.L. The relationship of human wound vascular endothelial growth factor (VEGF) after breast cancer surgery to circulating VEGF and angiogenesis. Clin Cancer Res 9 (2003) 4332-4339
17. Hyodo I., Doi T., Endo H., et al. Clinical significance of plasma vascular endothelial growth factor in gastrointestinal cancer. Eur J Cancer 34 (1998) 2041-2045
18. LaDue T., and Klein M.K. Toxicity criteria of the veterinary radiation therapy oncology group. Vet Radiol Ultrasound 42 (2001) 475-476
19. Liu Y., Cox S.R., Morita T., and Kourembanas S. Hypoxia regulates vascular endothelial growth factor gene expression in endothelial cells. Identification of a 5′ enhancer. Circ Res 77 (1995) 638-643
20. Maniwa Y., Okada M., Ishii N., and Kiyooka K. Vascular endothelial growth factor increased by pulmonary surgery accelerates the growth of micrometastases in metastatic lung cancer. Chest 114 (1998) 1668-1675
21. Mc Mahon G. VEGF-receptor signaling in tumor angiogenesis. Oncologist 5 (2000) 3-10
22. Mukhopadhyay D., Tsiokas L., Zhou X.M., Foster D., Brugge J.S., and Sukhatme V.P. Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation. Nature 375 (1995) 577-581
23. Nakamura Y., Yasuoka H., Tsujimoto M., et al. Prognostic significance of vascular endothelial growth factor D in breast carcinoma with long-term follow-up. Clin Cancer Res 9 (2003) 716-721
24. Owen L.N. The TNM classification of tumours in domestic animals (1980), World Health Organisation, Geneva p. 49
25. Shweiki D., Itin A., Soffer D., and Keshet E. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Lett Nat 359 (1992) 843-848
26. Veikkola T., Karkkainen M., Claesson-Welsh L., and Alitalo K. Regulation of angiogenesis via vascular endothelial growth factor receptors. Cancer Res 60 (2000) 203-212
27. Wergin M., and Kaser-Hotz B. Plasma Vascular endothelial growth factor (VEGF) in seventy dogs with spontaneously occuring tumors. Int J Vivo Res 18 (2004) 15-19
28. Wergin M.C., Ballmer-Hofer K., Roos M., et al. Preliminary study on plasma vascular endothelial growth factor during low- and high-dose radiation therapy of dogs with spontaneous tumors. Vet Radiol Ultrasound 45 (2004) 1-8
29. Werther K., Christensen I.J., and Nielsen H.J. Prognostic impact of matched preoperative plasma and serum VEGF in patients with primary colorectal carcinoma. Br J Cancer 86 (2002) 417-423
30. Wu Y., Saldana L., Chillar R., and Vadgama J.V. Plasma vascular endothelial growth factor is useful in assessing progression of breast cancer post surgery and during adjuvant treatment. Int J Oncol 20 (2002) 509-516
31. Wynendaele W., Derua R., Hoylaerts M.F., et al. Vascular endothelial growth factor measured in platelet poor plasma allows optimal separation between cancer patients and volunteers: a key to study an angiogenic marker in vivo?. Ann Oncol 10 (1999) 965-971
32. Zingg D., Riesterer O., Fabbro D., Glanzmann C., Bodis S., and Pruschy M. Differential activation of the phosphatidylinositol 3′-kinase/Akt survival pathway by ionizing radiation in tumor and primary endothelial cells. Cancer Res 64 (2004) 5398-5406
33. Zhong H., De Marzo A.M., Laughner E., et al. Overexpression of hypoxia-inducible factor-1α in common human cancers and their metastases. Cancer Res 59 (1999) 5830-5835