Flanking sequence composition differentially affects the binding and functional characteristics of glucocorticoid receptor homo- and heterodimers

Biochemistry

Volumn 45, Issue 23, 2006, Pages 7299-7306

  Morin, Brian ^a   Nichols, LaNita A ^a   Holland, Lené J ^a  

^a University of Missouri   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DIMERS; GENES; HORMONES; NUCLEIC ACIDS; PROTEINS;

CORE BINDING SITES; GENE-SPECIFIC CONTROL; TRANSCRIPTION FACTORS; XENOPUS GLUCOCORTICOID RECEPTOR ACCESSORY FACTOR (XGRAF);

BINDING ENERGY;

FIBRINOGEN; GAMMA FIBRINOGEN; GLUCOCORTICOID RECEPTOR; HETERODIMER; HOMODIMER; MONOMER; REGULATOR PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; XENOPUS GLUCOCORTICOID RECEPTOR ACCESSORY FACTOR;

ADOLESCENT; ANIMAL CELL; ARTICLE; BINDING SITE; DNA BASE COMPOSITION; DNA FLANKING REGION; DNA RESPONSIVE ELEMENT; FEMALE; GAMMA FIBRINOGEN GENE; GENE; GENE MUTATION; GENETIC TRANSCRIPTION; GLUCOCORTICOID RESPONSIVE ELEMENT; HORMONAL REGULATION; HORMONE RESPONSIVE ELEMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; RECEPTOR BINDING; REGULATOR GENE; TRANSCRIPTION FACTOR RESPONSE ELEMENT; TRANSCRIPTION REGULATION; XENOPUS LAEVIS;

ANIMALS; BASE SEQUENCE; DIMERIZATION; DNA PRIMERS; FEMALE; FIBRINOGEN; HEPATOCYTES; RECEPTORS, GLUCOCORTICOID; XENOPUS LAEVIS;

EID: 33745070996     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi060314k     Document Type: Article

References (33)

1. Lefstin, J. A., and Yamamoto, K. R. (1998) Allosteric effects of DNA on transcriptional regulators, Nature 392, 885-888.
2. Leung, T. H., Hoffmann, A., and Baltimore, D. (2004) One nucleotide in a κB site can determine cofactor specificity for NF-κB dimers, Cell 118, 453-464.
3. Natoli, G. (2004) Little things that count in transcriptional regulation, Cell 118, 406-408.
4. Kato, S., Sasaki, H., Suzawa, M., Masushige, S., Tora, L., Chambon, P., and Gronemeyer, H. (1995) Widely spaced, directly repeated PuGGTCA elements act as promiscuous enhancers for different classes of nuclear receptors, Mol. Cell. Biol. 15, 5858-5867.
5. Mangelsdorf, D. J., and Evans, R. M. (1995) The RXR heterodimers and orphan receptors, Cell 83, 841-850.
6. Winter, L. A., Stewart, M. J., Shean, M. L., Dong, Y., Poellinger, L., Okret, S., Gustafsson, J.-Å., and Duester, G. (1990) A hormone response element upstream from the human alcohol dehydrogenase gene ADH2 consists of three tandem glucocorticoid receptor binding sites, Gene 91, 233-240.
7. Connor, L. M., and Marriott, S. J. (2000) Sequences flanking the cAMP responsive core of the HTLV-I Tax response elements influence CREB protease sensitivity, Virology 270, 328-336.
8. Morin, B., Woodcock, G. R., Nichols, L. A., and Holland, L. J. (2001) Heterodimerization between the glucocorticoid receptor and the unrelated DNA-binding protein, Xenopus glucocorticoid receptor accessory factor, Mol. Endocrinol. 15, 458-466.
9. Mullick, J., Anandatheerthavarada, H. K., Amuthan, G., Bhagwat, S. V., Biswas, G., Camasamudram, V., Bhat, N. K., Reddy, S. E. P., Rao, V., and Avadhani, N. G. (2001) Physical interaction and functional synergy between glucocorticoid receptor and Ets2 proteins for transcription activation of the rat cytochrome P-450c27 promoter, J. Biol. Chem. 276, 18007-18017.
10. Stafford, J. M., Wilkinson, J. C., Beechem, J. M., and Granner, D. K. (2001) Accessory factors facilitate the binding of glucocorticoid receptor to the phosphoenolpyruvate carboxykinase gene promoter, J. Biol. Chem. 276, 39885-39891.
11. Gaunitz, F., Heise, K., and Gebhardt, R. (2004) A silencer element in the first intron of the glutamine synthetase gene represses induction by glucocorticoids, Mol. Endocrinol. 18, 63-69.
12. Ki, S. H., Cho, I. J., Choi, D. W., and Kim, S. G. (2005) Glucocorticoid receptor (GR)-associated SMRT binding to C/EBPβ TAD and Nrf2 Neh4/5: Role of SMRT recruited to GR in GSTA2 gene repression, Mol. Cell. Biol. 25, 4150-4165.
13. Nordeen, S. K., Ogden, C. A., Taraseviciene, L., and Lieberman, B. A. (1998) Extreme position dependence of a canonical hormone response element, Mol. Endocrinol. 12, 891-898.
14. Kelly, E. J., Sandgren, E. P., Brinster, R. L., and Palmiter, R. D. (1997) A pair of adjacent glucocorticoid response elements regulate expression of two mouse metallothionein genes, Proc. Natl. Acad. Sci. U.S.A. 94, 10045-10050.
15. Li, M., Ye, X., Woodward, R. N., Zhu, C., Nichols, L. A., and Holland, L. J. (1998) Analysis of the DNA-binding site for Xenopus glucocorticoid receptor accessory factor: Critical nucleotides for binding specificity in vitro and for amplification of steroid-induced fibrinogen gene transcription, J. Biol. Chem. 273, 9790-9796.
16. Woodward, R. N., Li, M., and Holland, L. J. (1997) Novel accessory factor-binding site required for glucocorticoid regulation of the γ-fibrinogen subunit gene from Xenopus laevis, Mol. Endocrinol. 11, 563-576.
17. Morin, B., Zhu, C., Woodcock, G. R., Li, M., Woodward, R. N., Nichols, L. A., and Holland, L. J. (2000) The binding site for Xenopus glucocorticoid receptor accessory factor and a single adjacent half-GRE form an independent glucocorticoid response unit, Biochemistry 39, 12234-12242.
18. d'Emden, M. C., Okimura, Y., and Maurer, R. A. (1992) Analysis of functional cooperativity between individual transcription-stimulating elements in the proximal region of the rat prolactin gene, Mol. Endocrinol. 6, 581-588.
19. Roberts, L. R., Nichols, L. A., and Holland, L. J. (1993) Transcriptional regulation of the Xenopus laevis Bβ fibrinogen subunit gene by glucocorticoids and hepatocyte nuclear factor 1: Analysis by transfection into primary liver cells, Biochemistry 32, 11627-11637.
20. Wood, K. V. (1991) The origin of beetle luciferases, in Bioluminescence and Chemiluminescence: Current Status (Stanley, P. E., and Kricka, L. J., Eds.) pp 11-14, John Wiley and Sons, Chichester, U.K.
21. Holland, L. J., Wall, A. A., and Bhattacharya, A. (1991) Xenopus liver ferritin H subunit: cDNA sequence and mRNA production in the liver following estrogen treatment, Biochemistry 30, 1965-1972.
22. La Baer, J., and Yamamoto, K. R. (1994) Analysis of the DNA-binding affinity, sequence specificity and context dependence of the glucocorticoid receptor zinc finger region, J. Mol. Biol. 239, 664-688.
23. Freedman, L. P., Luisi, B. F., Korszun, Z. R., Basavappa, R., Sigler, P. B., and Yamamoto, K. R. (1988) The function and structure of the metal coordination sites within the glucocorticoid receptor DNA binding domain, Nature 334, 543-546.
24. Srinivasan, G., and Thompson, E. B. (1990) Overexpression of full-length human glucocorticoid receptor in Spodoptera frugiperda cells using the baculovirus expression vector system, Mol. Endocrinol. 4, 209-216.
25. Aumais, J. P., Lee, H. S., DeGannes, C., Horsford, J., and White, J. H. (1996) Function of directly repeated half-sites as response elements for steroid hormone receptors, J. Biol. Chem. 271, 12568-12577.
26. Glantz, S. A. (1997) Primer of Biostatistics, 4th ed., McGraw-Hill, New York.
27. Tsai, S. Y., Carlstedt-Duke, J., Weigel, N. L., Dahlman, K., Gustafsson, J.-Å., Tsai, M.-J., and O'Malley, B. W. (1988) Molecular interactions of steroid hormone receptor with its enhancer element: Evidence for receptor dimer formation, Cell 55, 361-369.
28. Stormo, G. D. (2000) DNA binding sites: Representation and discovery, Bioinformatics 16, 16-23.
29. Wasserman, W. W., and Sandelin, A. (2004) Applied bioinformatics for the identification of regulatory elements, Nat. Rev. Genet. 5, 276-287.
30. Sandelin, A., and Wasserman, W. W. (2005) Prediction of nuclear hormone receptor response elements, Mol. Endocrinol. 19, 595-606.
31. Hallikas, O., Palin, K., Sinjushina, N., Rautiainen, R., Partanen, J., Ukkonen, E., and Taipale, J. (2006) Genome-wide prediction of mammalian enhancers based on analysis of transcription-factor binding affinity, Cell 124, 47-59.
32. Beato, M., Chalepakis, G., Schauer, M., and Slater, E. P. (1989) DNA regulatory elements for steroid hormones, J. Steroid Biochem. 32, 737-747.
33. Nordeen, S. K., Suh, B. J., Kühnel, B., and Hutchison, C. A., III (1990) Structural determinants of a glucocorticoid receptor recognition element, Mol. Endocrinol. 4, 1866-1873.