4-Aryl-5-oxo-1,2,3,4,5,6,7,8 -octahydroquinazoline-2-thione derivatives: Synthesis, enantiomeric separation and in vitro screening as calcium antagonists

Bollettino Chimico Farmaceutico

Volumn 136, Issue 11, 1997, Pages 657-664

  Sarac S ^a   Yarim, M ^a   Ertan, M ^a   Erol, K ^b   Aktan, Y ^b  

^a HACETTEPE UNIVERSITY   (Turkey)

^b ESKISEHIR OSMANGAZI UNIVERSITY   (Turkey)

Author keywords

Anellated tetrahydropyrimidine 2 thiones, pharmacology, synthesis; Calcium antagonists; Octahydroquinazoline 2 thiones, pharmacology, synthesis

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; 4 [2 (DIFLUOROMETHOXY)PHENYL] 1,4,5,7 TETRAHYDRO 2 METHYL 5 OXOFURO[3,4 B]PYRIDINE 3 CARBOXYLIC ACID ETHYL ESTER; 4 ARYL 5 OXO 1,2,3,4,5,6,7,8 OCTAHYDROQUINAZOLIN 2 THIONE; CALCIUM ANTAGONIST; NIFEDIPINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CALCIUM ANTAGONISM; CHEMICAL BOND; CONCENTRATION RESPONSE; DRUG DETERMINATION; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT;

ANIMALS; CALCIUM CHANNEL BLOCKERS; DRUG EVALUATION, PRECLINICAL; FEMALE; ILEUM; MALE; MUSCLE RELAXATION; QUINAZOLINES; RATS;

EID: 0031544856     PISSN: 00066648     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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