Effect of pentoxifylline and indomethacin on rabbits with endotoxin induced disseminated intravascular coagulation (DIC) and comparison with heparin

Turkish Journal of Hematology

Volumn 23, Issue 1, 2006, Pages 37-46

  Turgut, Burhan ^a   Vural, Özden ^a   Demir, Muzaffer ^a   Kutlu, Kemal ^a   Kayapinar, Ramazan ^a  

^a TRAKYA UNIVERSITY   (Turkey)

Author keywords

DIC; Endotoxin; Heparin; Indomethacin; Pentoxifylline

Indexed keywords

CYTOKINE; ESCHERICHIA COLI ENDOTOXIN; HEPARIN; INDOMETACIN; PENTOXIFYLLINE; PLACEBO; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICOAGULATION; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; CYTOKINE RELEASE; DISSEMINATED INTRAVASCULAR CLOTTING; DRUG EFFICACY; ENDOTOXEMIA; FIBRINOGEN BLOOD LEVEL; FIBRINOLYSIS; FIBROSIS; HEMOSTASIS; HISTOPATHOLOGY; MALE; MORTALITY; NONHUMAN; PARTIAL THROMBOPLASTIN TIME; PROTHROMBIN TIME; RABBIT; STATISTICAL SIGNIFICANCE; THROMBOCYTE COUNT;

EID: 33745037037     PISSN: 13007777     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Levi M, de Jonge E, van der Poll T, ten Cate H. Disseminated intravascular coagulation. Thromb Haemost 1999;82:695-705.
2. Weinstein L. Gram-negative bacterial infections: a look at the past, a view of the present, and a glance at the future. Rev Infect Dis 1985;7:538-44.
3. Cape HT, Sommeljer DW, Levi MM, eds. Disseminated intravascular coagulation in the new millennium. 7. Congress of the European Hematology Association, Educational program. Amsterdam, The Netherlands, 2002:86-95
4. Lopez-Aguirre Y, Paramo JA. Endothelial cell and hemostatic activation in relation to cytokines in patients with sepsis. Throm Research 1999;94:95-101.
5. Hack CE, Aarden LA, Thijs LG. Role of cytokines in sepsis. Adv Immunol 1997;66:101-95.
6. Hadjiminas DJ, McMasters KM, Robertson SE, Cheadle WG. Enhanced survival from cecal ligation and puncture with pentoxifylline is associated with altered neutrophil trafficking and reduced interleukin-1 beta expression but not inhibition of tumor necrosis factor synthesis. Surgery 1994;116:348-55.
7. Lauterbach R, Pawlik D, Kowalczyk D, Ksycinski W, Helwich E, Zembala M. Effect of the immunomodulating agent, pentoxifylline, in the treatment of sepsis in prematurely delivered infants: a placebo-controlled, double-blind trial. Crit Care Med 1999; 27:807-14.
8. Badger AM, Olivera DL, Esser KM. Beneficial effects of phosphodiesterase inhibitors BRL 61063, pentoxifylline, and rolipram in a murine model of endotoxin shock. Circ Shock 1994;44:188-95.
9. Schade UF. Pentoxifylline increases survival in murine endotoxin shock and decreases formation of tumor necrosis factor. Circ Shock 1990;31:171-81.
10. Chalkiadakis GE, Kostakis A, Karayannacos PE, Chalkiadakis ME, Sgouromali S, Giamarellou H, Skaldeas GD. Pentoxifylline in the treatment of experimental peritonitis in the rat. Arch Surg 1985;120:1141:44.
11. Ertel W, Morrison MH, Wang P, Ba ZF, Ayala A, Chaudry IH. The complex pattern of cytokines in sepsis. Association between prostaglandins, cachectin and interleukins. Ann Surg 1991;214: 141-8.
12. Mitchell PF. Therapeutic options directed against platelet activating factor, eicosanoids and bradykinin in sepsis. J Antimicrob Chemother 1998;41:81-94.
13. Gomez C, Paramo JA, Rocha E. Effect of heparin and/or antithrombib III in a model of disseminated intravascular coagulation induced by endotoxin in rabbits. Sangre 1992;337:5-10.
14. Hermida J, Montes R, Munoz MC, Orbe J, Paramo JA, Rocha E. Effects of low molecular weight heparin, alone or combined with antithrombin III, on mortality, fibrin deposits and hemostatic parameters in endotoxin-induced disseminated intravascular coagulation induced in rabbits. Am J Hematol 1999; 60:6-11.
15. Van der Poll T, Buller HR, ten Cate H, Wortel CH, Bouer KA, van Deventer SJ, Hack CE, Souer wein HP, Rosenberg RD, ten Cate JW. Activation of coagulation after administration of tumor necrosis factor to normal subjects. N Engl J Med 1990;322:1622-7.
16. Bauer KA, ten Cate H, Barzegar S, Spriggs Dr, Sherman ML, Rosenberg RD. Tumor necrosis factor infusions have a procoagulant effect on the hemostatic mechanism of humans. Blood 1989;74: 165-72.
17. Nawroth PP, Stern DM. Modulation of endothelial cell hemostatic properties by tumor necrosing factor. J Exp Med 1986;163:740.
18. Van der Poll T, Levi M, van Deventer SJ, ten Cate H, Haagmans BL, Biemond BJ, Buller HR, Hack CE, ten Cate JW. Differential effects of anti-tumor necrosis factor monoclonal antibodies on systemic inflammatory responses in experimental endotoxemia in chimpanzees. Blood 1994;83:446-51.
19. Conway EM, Rosenberg RD. Tumor necrosis factor suppresses transcription of the thrombomodulin gene in endothelial cells. Mol Cell Biol 1988;8:5588-92.
20. Biemond BJ, Levi M, ten Cate H, van der Poll T, Buller HR, Hack CE, ten Cate JW. Plasminogen activator and plasminogen activator inhibitor I release during experimental endotoxaemia in chimpanzees: effects of interventions in the cyotokine and coagulation cascades. Clin Sci 1995;88:587-94.
21. Doherty GM, Jensen JC, Alexander HR, Buresh CM, Norton JA. Pentoxifylline suppression of tumor necrosis factor gene transcription. Surgery 1991;110:192-8.
22. Pink MP. Whither pentoxifylline? Crit Care Med 1999;27:20.
23. Lissoni P, Ardizzoia A, Barni S, Pittalis S, Rossini F, Porta A, Tancini G. Characterization of cancer-related disseminated intravascular coagulation in relation to tumor necrosis factor-alpha blood concentrations: possible therapeutic role of pentoxifylline. Tumori 1996;82:78-80.
24. Josaki K, Contrino J, Kristie J, Krause P, Kreutzer DL. Pentoxifylline-induced modulation of human leukocyte function in vitro. Am J Pathol 1990;136:623-30.
25. Nelson JL, Alexander JW, Mao Ju-Xian, Vohs T, Ogle CK. Effects of pentoxifylline on survival and intestinal cytokine messenger RNA transcription in a rat model of ongoing peritoneal sepsis. Crit Care Med 1999;27:113-9.
26. 2 in human fibroblasts. J Biol Chem 1992; 267:23451-4.
27. Jones DA, Carlton DP, Molntyre TM, Zimmerman GA, Prescott SM. Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines. J Biol Chem 1993;268:9049-54.
28. Ristimaki A, Garfinkel S, Wessendorf J, Maciag T, Hla T. Induction of cyclooxygenase-2 by interleukin-1 alpha. Evidence for post-transcriptional regulation. J Biol Chem 1994;269:11769-75.
29. McAdam BF, Mardini LA, Habib A, Burke A, Lawson JA, Kapoor S, Fitz Gerald GA. Effect of regulated expression of human cyclooxygenase isoforms on eicosanoid and isoeicosanoid production in inflammation. J Clin Inv 2000;105:1473-82.
30. Hall-Angeras M, Saljo A, Hasselgren PO. Effect of methylprednisolone, indomethacin, and diethylcarbamazine on survival rate following trauma and sepsis in rats. Circ Shock 1986;20:231-8.
31. Hulton NR, Johnson DJ, Wilmore DW. Limited effects of prostaglandin inhibitors in Escherichia coli sepsis. Surgery 1985;98:291-7.
32. Fletcher JR, Ramwell PW. E. coli endotoxin shock in the dog; treatment with lidocaine or indomethacin. Br J Pharmacol 1978;64:185-91.
33. Jenkins JK, Carey PD, Byrne K, Sugerman HJ, Fowler AA. Sepsis-induced lung injury and the effects of ibuprofen pretreatment. Analysis of early alveolar events via repetitive bronchoalveolar lavage. Am Rev Respir Dis 1991;143:155-61.
34. Fink MP, McVittie TJ, Casey LC. Inhibition of prostaglandin sythesis restores normal hemodynamics in canine hyperdynamic sepsis. Ann Surg 1984; 200:619-26.
35. Hanly PJ, Sienko A, Light RB. Role of prostacyclin and thromboxane in the circulatory changes of acute bacteremic Pseudomonas pneumonia in dogs. Am Rev Respir Dis 1988;137:700-6.
36. Fletcher JR, Ramwell PW. Indomethacin treatment following baboon endotoxin shock improves survival. Adv Shock Res 1980;4:103-11.
37. Cilley RE, Polley TZ, Zwischenberger JB, Toomasian JM, Bartlett RH. Independent measurement of oxygen consumption and oxygen delivery. J Surg Res 1989;47:242-7.