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Role of Toll-like receptor 4 in Gram-positive and Gram-negative pneumonia in mice
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Differential roles of CD14 and Toll-like receptors 4 and 2 in murine Acinetobacter pneumonia
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Knapp S, Wieland CW, Florquin S, et al. Differential roles of CD14 and Toll-like receptors 4 and 2 in murine Acinetobacter pneumonia. Am J Respir Crit Care Med 2006; 173:122-129. This study tried to gain first insight into the role of CD14 and TLRs 4 and 2 in host responses to A. baumannii pneumonia using a murine model defective in the respective genes.
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Central role of toll-like receptor 4 signaling and host defense in experimental pneumonia caused by Gram-negative bacteria
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Schurr JR, Young E, Byrne P, et al. Central role of toll-like receptor 4 signaling and host defense in experimental pneumonia caused by Gram-negative bacteria. Infect Immun 2005; 73:532-545. In this study the role of TLR-4 signalling in coordinating gene expression was assessed by gene-expression profiling in lung tissue in a mouse model of experimental K. pneumoniae pneumonia.
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Schurr, J.R.1
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Surfactant protein a is a principal and oxidation-sensitive microbial permeabilizing factor in the alveolar lining fluid
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Kuzmenko AI, Wu H, Wan S, McCormack FX. Surfactant protein A is a principal and oxidation-sensitive microbial permeabilizing factor in the alveolar lining fluid. J Biol Chem 2005; 280:25913-25919. This study investigated the physiologic importance of surfactant protein A's ability to kill some Gram-negative organisms by increasing membrane permeability and the effect of oxidative stress on the antimicrobial functions of surfactant protein A.
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J Biol Chem
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Pseudomonas aeruginosa strains from nosocomial pneumonia are more serum resistant than P. aeruginosa strains from non-infectious respiratory colonization processes
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Vitkauskiene A, Scheuss S, Sahly H, et al. Pseudomonas aeruginosa strains from nosocomial pneumonia are more serum resistant than P. aeruginosa strains from non-infectious respiratory colonization processes. Infection 2005; 33:356-361.
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