Reexamining quinolone use in the intensive care unit: Use them right or lose the fight against resistant bacteria

Critical Care Medicine

Volumn 33, Issue 2, 2005, Pages 443-444

  Niederman, Michael S ^a,b  

^a STONY BROOK UNIVERSITY   (United States)

^b WINTHROP UNIVERSITY HOSPITAL   (United States)

Author keywords

Antibiotic resistance; Antibiotic therapy; Combination therapy; Duration of therapy; Fluoroquinolone; Multidrug resistant bacteria

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; ANTIBIOTIC AGENT; BETA LACTAM ANTIBIOTIC; BETA LACTAMASE; CARBAPENEM DERIVATIVE; CEFTAZIDIME; CEPHALOSPORIN DERIVATIVE; CIPROFLOXACIN; GATIFLOXACIN; GEMIFLOXACIN; IMIPENEM; LEVOFLOXACIN; MEROPENEM; METICILLIN; MOXIFLOXACIN; OFLOXACIN; PENICILLIN DERIVATIVE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; QUINOLONE;

ACINETOBACTER BAUMANNII; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ANTIBIOTIC THERAPY; ARTIFICIAL VENTILATION; BACTERIAL INFECTION; BACTERIUM CULTURE; BACTERIUM ISOLATE; CLINICAL PROTOCOL; CLINICAL TRIAL; CRITICAL ILLNESS; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG UTILIZATION; EDITORIAL; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HUMAN; INTENSIVE CARE UNIT; MORTALITY; MULTIDRUG RESISTANCE; OUTCOMES RESEARCH; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; RISK FACTOR; STAPHYLOCOCCUS AUREUS; STENOTROPHOMONAS MALTOPHILIA; VENTILATOR ASSOCIATED PNEUMONIA;

ANTI-BACTERIAL AGENTS; CROSS INFECTION; DRUG RESISTANCE, MULTIPLE, BACTERIAL; FLUOROQUINOLONES; HUMANS; INTENSIVE CARE UNITS;

EID: 13444257353     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000153527.76103.EF     Document Type: Editorial

References (12)

1. Richards MJ, Edwards JR, Culver DH, et al: Nosocomial infections in medical ICUs in the United States: National Nosocomial Infections Surveillance System. Crit Care Med 1999; 27:887-892
2. Luna CM, Vujacich P, Niederman MS, et al: Impact of BAL data on the therapy and outcome of ventilator-associated pneumonia. Chest 1997; 111:676-685
3. Kollef MH, Sherman G, Ward S, et al: Inadequate antimicrobial treatment of infections: A risk factor for hospital mortality among critically ill patients. Chest 1999; 115:462-474
4. Trouillet JL, Vuagnat A, Combes A, et al: Pseudomonas aeruginosa ventilator-associated pneumonia: Comparison of episodes due to piperacill in-resistant versus piperacillin-susceptible organisms. Clin Infect Dis 2002; 34:1047-1054
5. Ruhe JJ, Hasbu R: Streptococcus pneumoniae bacteremia: Duration of previous antibiotic use and association with penicillin resistance. Clin Infect Dis 2003; 36:1132-38
6. Nseir S, DiPompeo C, Soubrier S, et al: First-generation fluoroquinolone use and subsequent emergence of multiple drug-resistant bacteria in the intensive care unit. Crit Care Med 2005; 33:283-289
7. Livermore DM: Multiple mechanisms of antimicrobial resistance in Pseudomonas aemginosa: Our worst nightmare? Clin Infect Dis 2002; 34:634-640
8. Hoffken G, Niederman MS: Nosocomial pneumonia: The importance of a de-escalating strategy for antibiotic treatment of pneumonia in the ICU. Chest 2002; 122:2183-2196
9. Gruson D, Hilbert G, Vargas F, et al: Rotation and restricted use of antibiotics in a medical intensive care unit. Impact on the incidence of ventilator-associated pneumonia caused by antibiotic-resistant gram-negative bacteria. Am J Respir Crit Care Med 2000; 162:837-843
10. Luna CM, Blanzaco D, Niederman MS, et al: Resolution of ventilator-associated pneumonia: prospective evaluation of the clinical pulmonary infection score as an early clinical predictor of outcome. Crit Care Med 2003; 31:676-682
11. Chastre J, Wolff M, Fagon JY, et al: Comparison of 8 vs 15 days of antibiotic therapy for ventilator-associated pneumonia in adults: A randomized trial. JAMA 2003; 290:2588-2598
12. Fink MP, Snydman DR, Niederman MS, et al: Treatment of severe pneumonia in hospitalized patients: Results of a multicenter, randomized, double-blind trial comparing intravenous ciprofloxacin with imipenemcilastatin. The Severe Pneumonia Study Group. Antimicrob Agents Chemother 1994; 38:547-557