Dual surface immunoglobulin light-chain expression in B-cell lymphoproliferative disorders

Archives of Pathology and Laboratory Medicine

Volumn 130, Issue 6, 2006, Pages 853-856

  Xu, Dongsheng ^a  

^a BOSTON MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN KAPPA CHAIN; IMMUNOGLOBULIN LAMBDA CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; TUMOR MARKER;

ALLELE; B CELL LEUKEMIA; B CELL LYMPHOMA; CELL POPULATION; CHRONIC LYMPHATIC LEUKEMIA; FLOW CYTOMETRY; GENE EXPRESSION; GENE REARRANGEMENT; HUMAN; IMMUNOGLOBULIN GENE; IMMUNOPHENOTYPING; LYMPHOPROLIFERATIVE DISEASE; MALIGNANT NEOPLASTIC DISEASE; PRACTICE GUIDELINE; REVIEW; B LYMPHOCYTE; CELL CLONE; GENETICS; IMMUNOLOGY; METABOLISM; PATHOLOGY;

B-LYMPHOCYTES; CLONE CELLS; FLOW CYTOMETRY; GENE REARRANGEMENT, B-LYMPHOCYTE, LIGHT CHAIN; GUIDELINES; HUMANS; IMMUNOGLOBULIN KAPPA-CHAINS; IMMUNOGLOBULIN LAMBDA-CHAINS; LYMPHOPROLIFERATIVE DISORDERS; TUMOR MARKERS, BIOLOGICAL;

EID: 33745017259     PISSN: 00039985     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (17)

1. Korsmeyer SJ, Mieter PA, Ravetch JV, Poplack DC, Waldmann TA, Leder P. Developmental hierarchy of immunoglobulin gene rearrangements in human leukemic pre-B-cells. Proc Natl Acad Sci USA. 1981;78:7096-7100.
2. Tonegawa S. Somatic generation of antibody diversity. Nature. 1983;302:575-581.
3. Gerdes T, Wabl M. Autoreactivity and allelic inclusion in a B cell nuclear transfer mouse. Nat Immunol. 2004;5:1282-1287.
4. Rolink A, Grawunder U, Haasner D, Strasser A, Melchers F. Immature surface Ig+ B cells can continue to rearrange kappa and lambda L chain gene loci. J Exp Med. 1993;178:1263-1270.
5. Diaw L, Siwarski D, DuBois W, Jones C, Huppi K. Double producers of kappa and lambda define a subset of B cells in mouse plasmacytomas. Mol Immunol. 2000;37:775-781.
6. Giachino C, Radovan E, Lanzavecchia A. kappa+lambda+ dual receptor B cells are present in the human peripheral repertoire. J Exp Med. 1995;181:1245-1250.
7. Yu W, Nagaoka H, Jankovic M, et al. Continued RAG expression in late stages of B cell development and no apparent re-induction after immunization. Nature. 1999;400:682-687.
8. del Senno L, Gandini D, Gambari R, Lanza F, Tomasi P, Castoldi G. Monoclonal origin of B cells producing k, lambda and k lambda immunoglobulin light chains in a patient with chronic lymphocytic leukemia. Leuk Res. 1987;11:1093-1098.
9. Hardy RR, Dangl JL, Hayakawa K, Jager G, Herzenberg LA. Frequent lambda light-chain gene rearrangement and expression in a Ly-1 B lymphoma with a productive kappa chain allele. Proc Natl Acad Sci USA. 1986;83:1438-1442.
10. Liu D, Jenab J, Rosenberg N. Kappa and lambda rearrangement occur simultaneously in transformed pre-B cells. J Immunol. 1997;159:6061-6069.
11. Pauza ME, Rehmann JA, LeBien TW. Unusual patterns of immunoglobulin gene rearrangement and expression during human B cell ontogeny, human B cells can simultaneously express cell surface kappa and lambda light chains. J Exp Med. 1993;178:139-149.
12. Peltomaki P, Bianchi NO, Knuutila S, et al. Immunoglobulin kappa and lambda light-chain dual genotype rearrangement in a patient with kappa-secreting B-CLL. Eur J Cancer Clin Oncol. 1988;24:1233-1238.
13. Qin XF, Schwers S, Yu W, et al. Secondary V(D) J recombination in B-1 cells. Nature. 1999;397:355-359.
14. Coleclough C, Perry RP, Karjalainen K, Weigert M. Aberrant rearrangements contribute significantly to the allelic exclusion of immunoglobulin gene expression. Nature. 1981;290:372-378.
15. Casellas R, Shih TA, Kleinewietfeld M, et al. Contribution of receptor editing to the antibody repertoire. Science. 2001;291:1541-1544.
16. Kussick SJ, Kalnoski M, Braziel RM, Wood BL. Prominent clonal B-cell populations identified by flow cytometry in histologically reactive lymphoid proliferations. Am J Clin Pathol. 2004;121:464-472.
17. Kroft SH. Monoclones, monotypes, and neoplasia pitfalls in lymphoma diagnosis. Am J Clin Pathol. 2004;121:457-459.