A viable alternative to surgical vacuum aspiration: Repeated doses of intravaginal misoprostol over 9 hours for medical termination of pregnancies up to eight weeks

BJOG: An International Journal of Obstetrics and Gynaecology

Volumn 110, Issue 2, 2003, Pages 175-180

  Singh, Kuldip ^a   Fong, Y F ^b   Dong, F ^b  

^a NATIONAL UNIVERSITY HOSPITAL   (Singapore)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CHORIONIC GONADOTROPIN BETA SUBUNIT; MISOPROSTOL;

ABDOMINAL PAIN; ADOLESCENT; ADULT; ARTICLE; BLEEDING; BLOOD LEVEL; CLINICAL TRIAL; CONCEPTION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DRUG EFFICACY; FEMALE; HEMOGLOBIN DETERMINATION; HUMAN; HUMAN TISSUE; MENSTRUATION; PREGNANCY; PREGNANCY TERMINATION; PRIORITY JOURNAL; STATISTICAL ANALYSIS; THERAPEUTIC ABORTION; VACUUM ASPIRATION;

ABORTIFACIENT AGENTS; ABORTION, INDUCED; ADOLESCENT; ADULT; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; FEMALE; GESTATIONAL AGE; HUMANS; MIDDLE AGED; MISOPROSTOL; PREGNANCY; PREGNANCY TRIMESTER, FIRST; PROSPECTIVE STUDIES; TREATMENT OUTCOME; VACUUM CURETTAGE;

EID: 0037331232     PISSN: 14700328     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-0528.2003.02225.x     Document Type: Article

References (16)

1. Royal College of Obstetricians and Gynaecologists. The care of women requesting induced abortion. London: RCOG (Evidence-based Guideline No. 7), 2000.
2. Child T.J., Thomas J., Rees M., Mackenzie I.Z. A comparative study of surgical and medical procedures: 932 pregnancies terminations up to 63 days gestation. Hum Reprod. 16:2001;67-71.
3. Induced abortion operations and their early sequelae. J R Coll Gen Pract. 35:1985;175-180.
4. El-Refaey H., Rajasekar D., Abdalia M., Calder L., Templeton A. Induction of abortion with mifepristone (RU 486) and oral or vaginal misoprostol. N Engl J Med. 332:1995;983-987.
5. Koopersmith T.R., Mishell D.R. The use of misoprostol for termination of early pregnancy. Contraception. 53:1996;237-242.
6. Bugalho A., Faunders A., Jamisse L., Usfa M., Maria E., Bigue C. Evaluation of the effectiveness of vaginal misoprostol to induce first trimester abortion. Contraception. 53:1996;243-246.
7. Carbonell J.L.L., Varela L., Velazco A., Fernandez C. The use of misoprostol for termination of early pregnancy. Contraception. 55:1997;165-168.
8. Carbonell J.L.L., Varela L., Velazco A., Cabezas E., Tanda R., Sanchez C. Vaginal misoprostol for late first trimester abortion. Contraception. 57:1998;329-333.
9. Carbonell J.L.L., Varela L., Velazco A., Cabezas E., Tanda R., Sanchez C. Early abortion with 800 μg of misoprostol by the vaginal route. Contraception. 59:1999;219-225.
10. Ziemen M., Fong S.K., Benowitz N.L., Banskten D., Darney P.D. Absorption kinetics of misoprostol with oral or vaginal administration. Obstet Gynecol. 90:1997;88-92.
11. Grimes D.A. Medical abortion in early pregnancy: a review of the evidence. Obstet Gynecol. 89:1997;790-796.
12. Tang O.S., Wong K.S., Tang L.C.H., Ho P.C. Pilot study on the use of repeated doses of misoprostol in termination of pregnancy at less than 9 weeks of gestation. Adv Contracept. 15:1999;211-216.
13. Ngai S.W., Tang O.S., Chan Y.M., Ho P.C. Vaginal misoprostol alone for medical abortion up to 9 weeks of gestation: efficacy and acceptability. Hum Reprod. 15:2000;1159-1162.
14. Harwood B., Meckstroth R., Mishell D.R. Jr., Jain J.K. Serum beta-human chorionic gonadotropin levels and endometrial thickness after medical abortion. Contraception. 63:2001;255-256.
15. Creinin M.D. Changes in serum B-human chorionic gonadotropin after abortion with methotrexate and misoprostol. Am J Obstet Gynecol. 174(2):1995;776-778.
16. Tang O.S., Miao B.Y., Lee W.H.S., Ho P.C. Pilot study on the use of repeated doses of sublingual misoprostol in termination of pregnancy up to 12 weeks gestation: efficacy and acceptability. Hum Reprod. 17(3):2002;654-664.