Complete sequence data support lack of balancing selection on PRNP in a natural Chinese population

Journal of Human Genetics

Volumn 51, Issue 5, 2006, Pages 451-454

  Zan, Qin ^a   Wen, Bo ^a   He, Yungang ^a   Wang, Yi ^a   Xu, Shuhua ^a   Qian, Ji ^a   Lu, Daru ^a   Jin, Li ^a,b,c  

^a FUDAN UNIVERSITY   (China)

^b Chinese Academy of Sciences   (China)

^c UNIVERSITY OF CINCINNATI   (United States)

Author keywords

Balancing selection; Chinese; PRNP M129V

Indexed keywords

PRION PROTEIN;

ARTICLE; CHINESE; DNA POLYMORPHISM; GENE FREQUENCY; GENE SEQUENCE; GENETIC SELECTION; GENETIC VARIABILITY; GENOMICS; HUMAN; HYPOTHESIS; NORMAL HUMAN; NUCLEOTIDE SEQUENCE; POPULATION; POPULATION GENETICS; PROMOTER REGION;

ASIAN CONTINENTAL ANCESTRY GROUP; DATABASES, GENETIC; EVALUATION STUDIES; HUMANS; POPULATION GROUPS; PRIONS; VARIATION (GENETICS);

EID: 33745000777     PISSN: 14345161     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10038-006-0383-8     Document Type: Article

References (15)

1. Cann HM, de Toma C, Cazes L, Legrand MF, Morel V, Piouffre L, Bodmer J, Bodmer WF, Bonne-Tamir B, Cambon-Thomsen A, Chen Z, Chu J, Carcassi C, Contu L, Du R, Excoffier L, Ferrara GB, Friedlaender JS, Groot H, Gurwitz D, Jenkins T, Herrera RJ, Huang X, Kidd J, Kidd KK, Langaney A, Lin AA, Mehdi SQ, Parham P, Piazza A, Pistillo MP, Qian Y, Shu Q, Xu J, Zhu S, Weber JL, Greely HT, Feldman MW, Thomas G, Dausset J, Cavalli-Sforza LL (2002) A human genome diversity cell line panel. Science 296:261-262
2. Erginel-Unaltuna N, Peoc'h K, Komurcu E, Acuner TT, Issever H, Laplanche JL (2001) Distribution of the M129V polymorphism of the prion protein gene in a Turkish population suggests a high risk for Creutzfeldt-Jakob disease. Eur J Hum Genet 9:965-968
3. Forster P, Torroni A, Renfrew C, Röhl A (2001) Phylogenetic star contraction applied to Asian and Papuan mtDNA evolution. Mol Biol Evol 18:1864-1881
4. Fu YX, Li WH (1993) Statistical tests of neutrality of mutations. Genetics 133:693-709
5. Hammer MF, Blackmer F, Garrigan D, Nachman MW, Wilder JA (2003) Human population structure and its effects on sampling Y chromosome sequence variation. Genetics 164:1495-1509
6. Jeong BH, Nam JH, Lee YJ, Lee KH, Jang MK, Carp RI, Lee HD, Ju YR, Jo SA, Park KY, Kim YS (2004) Polymorphisms of the prion protein gene (PRNP) in a Korean population. J Hum Genet 49:319-324
7. Kreitman M, Di-Rienzo A (2004) Balancing claims for balancing selection. Trend Genet 20:300-304
8. Lee HS, Brown P, Cervenakova L, Garruto RM, Alpers MP, Gajdusek DC, Goldfarb LG (2001) Increased susceptibility to kuru of carriers of the PRNP 129 methionine/methionine genotype. J Infect Dis 183:192-196
9. Mead S, Stumph MPH, Whitfield J, Beck JA, Poulter M, Campbell T, Uphill JB, Goldstein D, Alpers M, Fisher EMC, Collinge J (2003) Balancing selection at the prion protein gene consistent with prehistoric kuru-like epidemics. Science 300:640-643
10. Rujescu D, Meisenzahl EM, Giegling I, Kirner A, Leinsinger G, Hegerl U, Hahn K, Möller HJ (2002) Methionine hemozygosity at codon 129 in the prion protein is associated with white matter reduction and enlargement of CSF compartments in health volunteers and schizophrenic patients. NeuroImage 15:200-206
11. Simonsen KL, Churchill GA, Aquadro CF (1995) Properties of statistical tests of neutrality for DNA polymorphism data. Genetics 141:413-429
12. Soldevila M, Calafell F, Helgason A, Stefansson K, Bertranpetit J (2005) Assessing the signatures of selection in PRNP from polymorphism data: results support Kreitman and Di Rienzo's opinion. Trends Genet 21:389-391
13. Stephens M, Smith N, Donnelly P (2001) A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 68:978-989
14. Tajima F (1989) Statistical method for testing the neutral mutation hypothesis by DNA polymorphism. Genetics 123:585-595
15. Yu SL, Jin L, Sy MS, Mei FH, Kang SL, Sun GH, Tien P, Wang FS, Xiao GF (2004) Polymorphisms of the PRNP gene in Chinese populations and the identification of a novel insertion mutation. Eur J Hum Genet 12:867-870