Women with hip fracture have a greater rate of decline in bone mineral density than expected: Another significant consequence of a common geriatric problem

Osteoporosis International

Volumn 17, Issue 7, 2006, Pages 971-977

  Magaziner, J ^a   Wehren, L ^a   Hawkes, W G ^a   Orwig, D ^a   Hebel, J R ^a   Fredman, L ^b   Stone, K ^c   Zimmerman, S ^d   Hochberg, M C ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b BOSTON UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Aging; Body composition; Bone mineral density; Epidemiology; Orthopaedics; Osteoporosis

Indexed keywords

AGED; ARTICLE; BONE DENSITY; COHORT ANALYSIS; COMMUNITY; CONTROLLED STUDY; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; FEMUR NECK; FOLLOW UP; HIP FRACTURE; HOSPITAL; HUMAN; MAJOR CLINICAL STUDY; MEASUREMENT; OSTEOLYSIS; PREVALENCE; PRIORITY JOURNAL; RACE; RISK ASSESSMENT; SMOKING; UNITED STATES;

ACTIVITIES OF DAILY LIVING; AGED; AGED, 80 AND OVER; BONE DENSITY; FEMALE; HIP FRACTURES; HUMANS;

EID: 33744997949     PISSN: 0937941X     EISSN: 14332965     Source Type: Journal    
DOI: 10.1007/s00198-006-0092-3     Document Type: Article

References (69)

1. Cooper C, Campion G, Melton LJ (1992) Hip fractures in the elderly: a world-wide projection. Osteoporos Int 2:285-289
2. Gullberg B, Johnell O, Kanis JA (1997) World-wide projections for hip fracture. Osteoporos Int 7:407-413
3. Magaziner J, Hawkes W, Hebel JR, Zimmerman SI, Fox KM, Dolan M et al (2000) Recovery from hip fracture in eight areas of function. J Gerontol A Biol Sci Med Sci 55A:M498-M507
4. Magaziner J, Lydick E, Hawkes W, Fox KM, Zimmerman SI, Epstein RS et al (1997) Excess mortality attributable to hip fracture in white women aged 70 years and older. Am J Public Health 87:1630-1636
5. Magaziner J, Fredman L, Hawkes W, Hebel JR, Zimmerman S, Orwig DL et al (2003) Changes in functional status attributable to hip fracture: a comparison of hip fracture patients to community-dwelling aged. Am J Epidemiol 157:1023-1031
6. Wehren LE, Magaziner J (2003) Hip fracture: risk factors and outcomes. Curr Osteoporos Rep 1:78-85
7. van Balen R, Steyerberg EW, Polder JJ, Ribbers TLM, Habbema JDF, Cools HJM (2001) Hip fracture in elderly patients: outcomes for function, quality of life, and type of residence. Clin Ortop 390:232-243
8. Braithwaite RS, Col NF, Wong JB (2003) Estimating hip fracture morbidity, mortality and costs. J Am Geriatr Soc 51:364-370
9. Ray NF, Chan JK, Thamer M, Melton LJ (1997) Medical expenditures for the treatment of osteoporotic fractures in the United States in 1995: report from the National Osteoporosis Foundation. J Bone Miner Res 12:24-35
10. Brainsky A, Glick H, Lydick E, Epstein R, Fox KM, Hawkes W et al (1997) The economic cost of hip fractures in community-dwelling older adults: a prospective study. J Am Geriatr Soc 45:281-287
11. Kashner T, Magaziner J, Pruitt S (1990) Family size and caregiving of aged parents with hip fractures. In: Biegel D, Blum A (eds) Aging and caregiving: theory, research and policy. Sage Publications, Beverly Hills, CA, pp 184-203
12. Saltz CC, Zimmerman SI, Tompkins C, Harrington D, Magaziner J (1999) Stress among caregivers of hip fracture patients: a longitudinal study. J Gerontol Soc Work 30:167-181
13. Melton LJ 3rd, Gabriel SE, Crowson CS, Tosteson AN, Johnell O, Kanis JA (2003) Cost-equivalence of different osteoporotic fractures. Osteoporos Int 14(5):383-388
14. Melton LJI (1993) Hip fractures: a worldwide problem today and tomorrow. Bone 14:S1-S8
15. Jones G, Nguyen T, Sambrook P, Kelly PJ, Eisman JA (1994) Progressive loss of bone in the femoral neck in elderly people: longitudinal findings from the Dubbo Osteoporosis Epidemiology Study. Br Med J 309:691-695
16. Ensrud KE, Palermo L, Black DM, Cauley J, Jergas M, Orwoll ES et al (1995) Hip and calcaneal bone loss increase with advancing age: longitudinal results from the Study of Osteoporotic Fractures. J Bone Miner Res 10(11):1778-1787
17. Burger H, de Laet CEDH, van Daele PLA, Weel AEAM, Witteman JCM, Hofman A et al (1998) Risk factors for increased bone loss in an elderly population: the Rotterdam Study. Am J Epidemiol 147(9):871-879
18. Dennison E, Eastell R, Fall CHD, Kellingray S, Wood PJ, Cooper C (1999) Determinants of bone loss in elderly men and women: a prospective population-based study. Osteoporos Int 10:384-391
19. Karlsson MK, Obrant KJ, Nilsson BE, Johnell O (2000) Changes in bone mineral, lean body mass and fat content as measured by dual energy X-ray absorptiometry: a longitudinal study. Calcif Tissue Int 66:97-99
20. Melton LJ III, Atkinson EJ, O'Connor MK, O'Fallon WM, Riggs BL (2000) Determinants of bone loss from the femoral neck in women of different ages. J Bone Miner Res 15(1):24-31
21. Karlsson M, Nilsson JA, Sernbo I, Redlund-Johnell I, Johnell O, Obrant KJ (1996) Changes of bone mineral mass and soft tissue composition after hip fracture. Bone 18(1):19-22
22. Dirschl DR, Henderson RC, Oakley WC (1997) Accelerated bone mineral loss following a hip fracture: a prospective longitudinal study. Bone 21(2):79-82
23. Fox KM, Magaziner J, Hawkes WG, Yu-Yahiro J, Hebel JR, Zimmerman SI et al (2000) Loss of bone density and lean body mass after hip fracture. Osteoporos Int 11(1):31-35
24. Colón-Emeric C, Kuchibhatla M, Pieper C, Hawkes W, Fredman L, Magaziner J et al (2003) The contribution of hip fracture to risk of secondary fractures: data from two longitudinal studies. Osteoporos Int 14(11):879-883
25. Schroder HM, Petersen KK, Erlandsen M (1993) Occurrence and incidence of the second hip fracture. Clin Ortop 289:166-169
26. Chapurlat RD, Bauer DC, Nevitt M, Stone K, Cummings SR (2003) Incidence and risk factors for a second hip fracture in elderly women. The Study of Osteoporotic Fractures. Osteoporos Int 14(2):130-136
27. Cummings SR, Nevitt MC, Browner WS, Stone K, Fox KM, Ensrud KE et al (1995) Risk factors for hip fracture in white women. Study of Osteoporotic Fractures Research Group. N Engl J Med 332(12):767-773
28. Cummings SR, Black DM, Nevitt MC, Browner WS, Cauley JA, Genant HK et al (1990) Appendicular bone density and age predict hip fracture in women. JAMA 263:665-668
29. Steiger P, Cummings SR, Black DM, Spencer NE, Genant HK (1992) Age-related decrements in bone mineral density in women over 65. J Bone Miner Res 7(6):625-632
30. Fredman L, Hawkes W, Zimmerman SI, Hebel JR, Magaziner J (2001) Extending gerontological research through linking investigator's studies to public-use datasets. Gerontologist 41 (1):15-22
31. Wolinsky FD, Fitzgerald JF, Stump TE (1997) The effect of hip fracture on mortality, hospitalization, and functional status: a prospective study. Am J Public Health 87(3):398-403
32. Fredman L, Magaziner J, Hawkes W, Hebel JR, Fried LP, Kasper J et al (2005) Female hip fracture patients had poorer performance-based functioning than community-dwelling peers over 2-year follow-up period. J Clin Epidemiol 58(12):1289-1298
33. Sherrington C, Lord SR (1998) Increased prevalence of fall risk factors in older people following hip fracture. Gerontology 44:340-344
34. Nevitt MC, Cummings SR, Hudes ES (1991) Risk factors for injurious falls: a prospective study. J Gerontol 46(5):M164-M170
35. Tromp AM, Smit JH, Deeg DJH, Bouter LM, Lips P (1998) Predictors for falls and fractures in the Longitudinal Aging Study Amsterdam. J Bone Miner Res 13(12):1932-1939
36. King MB, Tinetti ME (1995) Falls in community-dwelling older persons. J Am Geriatr Soc 43:1146-1154
37. Dretakis KE, Dretakis EK, Papakitsou EF, Psarakis S, Steriopoulos K (1998) Possible predisposing factors for the second hip fracture. Calcif Tissue Int 62:366-369
38. Jorgensen L, Jacobsen BK (2001) Changes in muscle mass, fat mass, and bone mineral content in the legs after stroke: a 1 year prospective study. Bone 28:655-659
39. Uebelhart D, Bernard J, Hartmann DJ, Moro L, Roth M, Uebelhart B et al (2000) Modifications of bone and connective tissue after orthostatic bedrest. Osteoporos Int 11(1):59-67
40. LeBlanc A, Schneider V, Shackelford L, West S, Oganov V, Bakulin A et al (2000) Bone mineral and lean tissue loss after long duration space flight. J Musculoskel Neuron Interact 1:157-160
41. LeBlanc AD, Schneider VS, Evans HJ, Engelbretson DA, Krebs JM (1990) Bone mineral loss and recovery after 17 weeks of bed rest. J Bone Miner Res 5:843-850
42. Jorgensen L, Jacobsen BK, Wisgaard T, Magnus JH (2000) Walking after stroke: does it matter? Changes in bone mineral density within the first 12 months after stroke. A longitudinal study. Osteoporos Int 11:381-387
43. LeBoff MS, Kohlmeier L, Hurwitz S, Franklin J, Wright J, Glowacki J (1999) Occult vitamin D deficiency in postmenopausal US women with acute hip fracture. JAMA 281 (16):1501-1511
44. Yu-Yahiro JA, Michael RH, Dubin NH, Fox KM, Sachs M, Hawkes W et al (2001) Serum and urine markers of bone metabolism during the year after hip fracture. J Am Geriatr Soc 49:877-883
45. Dubin NH, Monahan LK, Yu-Yahiro JA, Michael RH, Zimmerman SI, Hawkes W et al (1999) Serum concentrations of steroids, parathyroid hormone, and calcitonin in postmenopausal women during the year after hip fracture: effect of location of fracture and age. J Gerontol: Med Sci 54A(9):M467-M473
46. Garnero P, Hausherr E, Chapuy M-C, Marcelli C, Grandjean H, Muller C et al (1996) Markers of bone resorption predict hip fracture in elderly women: the EPIDOS prospective study. J Bone Miner Res 11(10):1531-1538
47. Akesson K, Vergnaud P, Gineyts E, Delmas PD, Obrant KJ (1993) Impairment of bone turnover in elderly women with hip fracture. Calcif Tissue Int 53:162-169
48. Wehren LE, Hawkes W, Hebel JR, Orwig D, Zimmerman SI, Fox KM et al (2004) Predictors of bone loss after hip fracture. Osteoporos Int 15:125-131
49. National Osteoporosis Foundation (2003) Physician's guide to prevention and treatment of osteoporosis. National Osteoporosis Foundation, Washington, DC
50. National Osteoporosis Foundation (2003) Health professional's guide to rehabilitation of the patient with osteoporosis. National Osteoporosis Foundation, Washington, DC
51. Orwig DL, Wehren LE, Yu-Yahiro JA, Hochberg M, Magaziner J (2001) Treatment of osteoporosis following a hip fracture: sending results of bone densitometry to primary care physicians does not increase use of pharmacologic therapy (Abstract F382). J Bone Miner Res 16(Suppl 1):S220
52. Juby AG, De Geus-Wenceslau CM (2002) Evaluation of osteoporosis treatment in seniors after hip fracture. Osteoporos Int 13:205-210
53. Solomon DH, Finkelstein JS, Katz JN, Mogun H, Avorn J (2003) Underuse of osteoporosis medications in elderly patients with fractures. Am J Med 115:398-400
54. Simonelli C, Chen Y-T, Morancey J, Lewis AF, Abbott TAI (2003) Evaluation and management of osteoporosis following hospitalization for low-impact fracture. J Gen Intern Med 18:17-22
55. Kamel HK, Duthie EH (2002) The underuse of therapy in the secondary prevention of hip fractures. Drugs Aging 19:1-10
56. Harrington JT, Broy SB, Derosa AM, Licata AA, Shewmon DA (2002) Hip fracture patients are not treated for osteoporosis: a call to action. Arthritis Rheum 47:651-654
57. Gardner MJ, Flik K, Mooar PA, Lane JM (2002) Improvement in the undertreatment of osteoporosis following hip fracture. J Bone Joint Surg 84-A:1342-1348
58. Follin S, Black J, McDermott M (2003) Lack of diagnosis and treatment of osteoporosis in men and women after hip fracture. Pharmacotherapy 23:190-198
59. Bahl S, Coates PS, Greenspan SL (2003) The management of osteoporosis following hip fracture: have we improved our care? Osteoporos Int 14(11):884-888
60. Jachna CM, Whittle J, Lukert B, Graves L, Bhargava T (2003) Effect of hospitalist consultation on treatment of osteoporosis in hip fracture patients. Osteoporos Int 14(8):665-671
61. Black JN, Follin SL (2001) Osteoporosis diagnosis and management following hip fracture [abstract]. J Bone Miner Res 16(Suppl 1):S214
62. Cree MW, Juby AG, Carriere KC (2003) Mortality and morbidity associated with osteoporosis drug treatment following hip fracture. Osteoporos Int 14(9):722-727
63. Bellantonio S, Fortinsky RH, Prestwood K (2001) How well are community-living women treated for osteoporosis after hip fractures? J Am Geriatr Soc 49:1197-1204
64. Kaufman JD, Bolander ME, Bunta AD, Edwards BJ, Fitzpatrick LA, Simonelli C (2003) Barriers and solutions to osteoporosis care in patients with a hip fracture. J Bone Joint Surg Am 85-A(9):1837-1843
65. Taylor JC, Sterkel B, Utley M, Shipley M, Newman S, Horton M et al (2001) Opinions and experiences in general practice on osteoporosis prevention, diagnosis, and management. Osteoporos Int 12:844-848
66. Simonelli C, Killeen K, Mehle S, Swanson L (2002) Barriers to osteoporosis identification and treatment among primary care physicians and orthopedic surgeons. Mayo Clinic Proc 77:334-338
67. Morris AH, Zuckerman JD (2002) National Consensus Conference on Improving the Continuum of Care for Patients with Hip Fracture. J Bone Joint Surg Am 84-A(4):670-674
68. Chilov MN, Cameron ID, March LM (2003) Evidence-based guidelines for fixing broken hips: an update. Med J Aust 179 (9):489-493
69. Freitag MH, Magaziner J (2006) Post-operative considerations in hip fracture management. Curr Rheumatol Rep 8(1):55-62