A pilot study of 1 versus 3 days of dexamethasone as add-on therapy in children with streptococcal pharyngitis

Pediatric Infectious Disease Journal

Volumn 25, Issue 6, 2006, Pages 477-481

  Niland, Mary Lynn ^a,b   Bonsu, Bema K ^a   Nuss, Kathryn E ^a   Goodman, Deborah G ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b Section of Pediatric Gastroenterology   (United States)

Author keywords

Dexamethasone therapy; Group A streptococcus; Streptococcal pharyngitis

Indexed keywords

ANTIBIOTIC AGENT; DEXAMETHASONE; PLACEBO; STEROID;

ABSENTEEISM; ADD ON THERAPY; ADOLESCENT; ADULT; AGE DISTRIBUTION; ARTICLE; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DATA ANALYSIS; DISEASE SEVERITY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG DOSE REGIMEN; DRUG EFFICACY; FACES PAIN SCALE; FEMALE; FOLLOW UP; HUMAN; INTERVIEW; MAJOR CLINICAL STUDY; MALE; PHARYNGITIS; PHYSICAL ACTIVITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; SCHOOL; STREPTOCOCCUS GROUP A; STREPTOCOCCUS INFECTION; SURVIVAL; TELEPHONE; TREATMENT DURATION; TREATMENT OUTCOME;

EID: 33744983518     PISSN: 08913668     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.inf.0000219469.95772.3f     Document Type: Article

References (17)

1. Bisno AL, Gerber MA, Gwaltney JM, Kaplan EL, Schwartz RH. Practice guidelines for the diagnosis and management of group A streptococcal pharyngitis. Clin Infect Dis. 2002;35:113-125.
2. Zwart S, Rovers MM, de Melker RA, Hoes AW. Penicillin for acute sore throat in children: Randomized, double blind trial. BMJ. 2003;327:1-5.
3. Del Mar C, Glasziou PP. Antibiotics for sore throats? J Paediatr Child Health. 1998;34:498-499.
4. Del Mar C, Glasziou PP, Spinks AB. Antibiotics for sore throats. Cochrane Database Syst Rev. 2000;4:CD000023.
5. O'Brien JF, Meade JL, Falk JL. Dexamethasone as adjuvant therapy for severe acute pharyngitis. Ann Emerg Med. 1993;22:2:70-73.
6. Marvez-Valls EG, Ernst AA, Gray J, Johnson WD. The role of betamethasone in the treatment of acute exudative pharyngitis. Acad Emerg Med. 1998;5:567-572.
7. Marvez-Valls EG, Stuckey A, Ernst AA. A randomized clinical trial of oral versus intramuscular delivery of steroids in acute exudative pharyngitis. Acad Emerg Med. 2002;9:9-14.
8. Wei JL, Kasperbauer JL, Weaver AL, Boggust AJ. Efficacy of single-dose dexamethasone as adjuvant therapy for acute pharyngitis. Laryngoscope. 2002;112:87-93.
9. Ganzel TM, Goldman JL, Padhya TA. Otolaryngologic clinical patterns in pediatric infectious mononucleosis. Am J Otolaryngol. 1996;17:397-400.
10. Bulloch B, Kabani A, Tenenbein M. Oral dexamethasone for the treatment of pain in children with acute pharyngitis: a randomized, double-blind, placebo-controlled trial. Ann Emerg Med. 2003;41:5:601-608.
11. Olympia RP, Khine H, Avner JR. Effectiveness of oral dexamethasone in the treatment of moderate to severe pharyngitis in children. Arch Pediatr Adolesc Med. 2005;159:278-282.
12. Wong D, Baker C. Pain in children: Comparison of assessment scales. Pediatr Nurs. 1988;14:9-17.
13. Keck J, Gerkensmeyer J, Joyce B, Schade J. Reliability and validity of the FACES and word descriptor scales to measure pain in verbal children. J Pediatr Nurs. 1996;11:368-374.
14. Harris A. Survivorship Analysis for Clinical Studies. Statistics: Textbooks and Monograph, series no. 114. Marcel Dekker; 1991.
15. Kleinbaum DG. Survival Analysis. A Self-Learning Text. Statistics in the Health Sciences. Springer-Verlag; 1996.
16. Prentice RL, Marek P. A qualitative discrepancy between censored rank tests. Biometrics. 1979;34:861-867.
17. Kalbfleisch JD, Prentice RL. The Statistical Analysis of Failure Time Data. New York: John Wiley; 1980.