Oral dexamethasone for the treatment of pain in children with acute pharyngitis: A randomized, double-blind, placebo-controlled trial

Annals of Emergency Medicine

Volumn 41, Issue 5, 2003, Pages 601-608

  Bulloch, Blake ^a,b   Kabani, Amin ^a   Tenenbein, Milton ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

^b PHOENIX CHILDREN'S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; PLACEBO; STREPTOCOCCUS ANTIGEN;

ADOLESCENT; ANALGESIA; ANTIGEN DETECTION; ARTICLE; BETA HEMOLYTIC STREPTOCOCCUS; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE ASSOCIATION; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; EMERGENCY WARD; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PAIN; PAIN ASSESSMENT; PHARYNGITIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME; TREATMENT PLANNING; VISUAL ANALOG SCALE;

EID: 0037408305     PISSN: 01960644     EISSN: None     Source Type: Journal    
DOI: 10.1067/mem.2003.136     Document Type: Article

References (18)

1. American Academy of Pediatrics. Group A streptococcal infections. In: Peter G, ed. 1997 Red Book: Report of the Committee on Infectious Diseases. 24th ed. Elk Grove Village, IL: American Academy of Pediatrics; 1997:483-490.
2. Krober MS, Bass JW, Michels GN. Streptococcal pharyngitis: placebo-controlled double-blind evaluation of clinical response to penicillin therapy. JAMA. 1985;253:1271-1274.
3. Klassen TP, Craig WR, Moher D, et al. Nebulized budesonide and oral dexamethasone for treatment of croup. A randomized controlled trial. JAMA. 1998;279:1629-1632.
4. Oureshi F, Zaritsky A, Poirier MP. Comparative efficacy of oral dexamethasone versus oral prednisone in acute pediatric asthma. J Pediatr. 2001;139:20-26.
5. Tom LW, Templeton JJ, Thompson ME, et al. Dexamethasone in adenotonsillectomy. Int J Pediatr Otorhinolaryngol. 1996;37:115-120.
6. O'Brien JF, Meade JL, Falk JL. Dexamethasone as adjuvant therapy for severe acute pharyngitis. Ann Emerg Med. 1993;22:212-215.
7. Marvez-Valls EG, Ernst AA, Gray J, et al. The role of betamethasone in the treatment of acute exudative pharyngitis. Acad Emerg Med. 1998;5:567-572,
8. Wei JL, Kasperbauer JL, Weaver AL, et al. Efficacy of single-dose dexamethasone as adjuvant therapy for acute pharyngitis. Laryngoscope. 2002;112:87-93.
9. Marvez-Valls EG, Stuckey A, Ernst AA. A randomized clinical trial of oral versus intramuscular delivery of steroids in acute exudative pharyngitis. Acad Emerg Med. 2002;9:9-14.
10. McGrath PA, Seifert CE, Speechley KN, et al. A new analogue scale for assessing children's pain: an initial validation study. Pain. 1996;64:435-443.
11. McGrath PJ, Cunningham SJ, Goodman JT, et al. The clinical measurement of pain in children: a review. Clin J Pain. 1985;1:221-227.
12. Bulloch B, Tenenbein M. Validation of two pain scales for use in the pediatric emergency department. Pediatrics. 2002;110:e33.
13. Bulloch B, Tenenbein M. Assessment of clinically important changes in pain scales for use in children in the emergency department. Acad Emerg Med. 2002;9:199-202.
14. Eland JM, Anderson JE. The experience of pain in children. In: Jacox AK, ed. Pain: A Sourcebook for Nurses and Other Health Professionals. Boston, MA: Little, Brown & Co; 1977:453-473.
15. Haynes RC Jr. Adrenal Corticosteroids. In: Goodman Gilman A, Rall TW, Nies AS, et al, eds. The Pharmacological Basis of Therapeutics. 8th ed. New York, NY: Pergamon Press; 1990:1431-1462.
16. Todd KH, Funk KG, Funk JP, et al. Clinical significance of reported changes in pain severity. Ann Emerg Med. 1996;27:485-489.
17. Todd KH. Clinical versus statistical significance in the assessment of pain relief. Ann Emerg Med. 1996;27:439-441.
18. Nevin K. Influence of sex on pain assessment and management. Ann Emerg Med. 1996;27:424-426.