The safety of autologous intracoronary stem cell injections in a porcine model of chronic myocardial ischemia

Journal of Invasive Cardiology

Volumn 18, Issue 5, 2006, Pages 212-218

  Bhakta, Shyam ^b   Greco, Nicholas J ^b   Finney, Marcie R ^a   Hoffman, Robert D ^c   Joseph, Matthew E ^b   Banks, Jason J ^a   Laughlin, Mary J ^a   Pompili, Vincent J ^a,b  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,1 DIOCTADECYL 3,3,3',3' TETRAMETHYLINDOCARBOCYANINE PERCHLORATE; CARBOCYANINE; DYE; TROPONIN I; UNCLASSIFIED DRUG; FLUORESCENT DYE;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; BONE MARROW DERIVED MONONUCLEAR CELL; CELLULAR DISTRIBUTION; CUFF; DISEASE MODEL; EVALUATION; FEASIBILITY STUDY; HEART; HEART MUSCLE ISCHEMIA; HISTOPATHOLOGY; IMMUNOFLUORESCENCE MICROSCOPY; MONONUCLEAR CELL; NONHUMAN; OUTCOME ASSESSMENT; SAFETY; SPLEEN; STEM CELL TRANSPLANTATION; SWINE; ANIMAL; BONE MARROW; CHRONIC DISEASE; CORONARY BLOOD VESSEL; HEART MUSCLE; INTRAARTERIAL DRUG ADMINISTRATION; METHODOLOGY; PATHOLOGY; STEM CELL;

ANIMALS; BONE MARROW; CHRONIC DISEASE; CORONARY VESSELS; FEASIBILITY STUDIES; FLUORESCENT DYES; INJECTIONS, INTRA-ARTERIAL; MYOCARDIAL ISCHEMIA; MYOCARDIUM; SPLEEN; STEM CELL TRANSPLANTATION; STEM CELLS; SWINE;

EID: 33744978770     PISSN: 10423931     EISSN: 15572501     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Wollert KC, Drexler H. Clinical applications of stem cells for the heart. Circ Res 2005;96:151-163.
2. Tse HF, Kwong Y, Chan JKF, et al. Angiogenesis in ischaemic myocardium by intramyocardial autologous bone marrow mononuclear cell implantation. Lancet 2003;361:47-49.
3. Perin EC, Dohmann HFR, Borojevic R, et al. Transendocardial, autologous bone marrow transplantation for severe chronic ischemic heart failure. Circulation 2003;107:2294-2302.
4. Hamano K, Nishida M, Hirata K, et al. Local implantation of autologous bone marrow cells for therapeutic angiogenesis in patients with ischemic heart disease. Jpn Circ J 2001;65:845-847.
5. Fuchs S, Satler LF, Kornowski R, et al. Catheter-based autologous bone marrow myocardial injection in no-option patients with advanced coronary artery disease. J Am Coll Cardiol 2003;41:1721-1724.
6. Stone GW, Kandzari DE, Mehran R, et al. Percutaneous recanalization of chronically occluded coronary arteries: A consensus document. Part I. Circulation 2005;112:2364-2372.
7. Strauer BE, Brehm M, Zeus T, et al. Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans. Circulation 2002;106:1913-1918.
8. Assmus B, Schachinger V, Teupe C, et al. Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI). Circulation 2002;106:3009-3017.
9. Fernandez-Aviles F, San Roman JA, Garcia-Frade J, et al. Experimental and clinical regenerative capability of human bone marrow cells after myocardial infarction. Circ Res 2004;95:742-748.
10. Keuthe F, Richartz BM, Sayer HG, et al. Lack of regeneration of myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans with large anterior myocardial infarctions. Int J Cardiol 2004;97:123-127.
11. Wollert KC, Meyer GP, Lotz J, et al. Intracoronary autologous bone-marrow cell transfer after myocardial infarction: The BOOST randomised controlled clinical trial. Lancet 2004;364:141-148.
12. Chen SL, Fang WW, Ye F, et al. Effect on left ventricular function of intracoronary transplantation of autologous bone marrow mesenchymal stem cell in patients with acute myocardial infarction. Am J Cardiol 2004;94:92-95.
13. Vanderheyden M, Mansour S, Vandekerckhove B, et al. Selected intracoronary CD133+ bone marrow cells promote cardiac regeneration after acute myocardial infarction. Circulation 2004;110(Suppl III):324-325.
14. Koc ON, Gerson SL, Cooper BW, et al. Rapid hematopoetic recovery after coninfusion of autologous-blood stem cells and culture-expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapy. J Clin Oncol 2000;18:307-316.
15. Stamm C, Kleine HD, Westphal B, et al. CABG and bone marrow stem cell transplantation after myocardial infarction. Thorac Cardiov Surg 2004;52:152-158.
16. Erbs S, Linke A, Adams V, et al. Transplantation of blood-derived progenitor cells after recanalization of chronic coronary artery occlusion. First randomized and placebo-controlled study. Circ Res 2005;97:756-762.
17. Dohmann HFR, Perin EC, Takiya CM, et al. Transendocardial autologous bone Marrow mononuclear cell injection in ischemic heart failure. Postmortem anatomicopathologic and immunohistochemical findings. Circulation 2005;112:521-526.
18. Stamm C, Kleine HD, Westphal B, et al. CABG and bone marrow stem cell transplantation after myocardial infarction. Thorac Cardiov Surg 2004;52:152-158.