Differential expression of alternatively spliced mRNA forms of the insulin-like growth factor 1 receptor in human neuroendocrine tumors

Oncology Reports

Volumn 15, Issue 5, 2006, Pages 1249-1256

  Vitale, Lorenza ^a   Lenzi, Luca ^a   Huntsman, Shane A ^b   Canaider, Silvia ^a   Frabetti, Flavia ^a   Casadei, Raffaella ^a   Facchin, Federica ^a   Carinci, Paolo ^a   Zannotti, Maria ^a   Coppola, Domenico ^b   Strippoli, Pierluigi ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

'subtle' alternative splicing; IGF1R; Neuroendocrine tumors; Semiquantitative PCR

Indexed keywords

ISOPROTEIN; MESSENGER RNA; PRIMER DNA; RNA; SOMATOMEDIN C RECEPTOR;

ADULT; AGED; ALTERNATIVE RNA SPLICING; AMINO ACID SEQUENCE; ARTICLE; CELL DIFFERENTIATION; CHEMISTRY; COMPARATIVE STUDY; FEMALE; GENETICS; HEAD AND NECK TUMOR; HUMAN; MALE; METABOLISM; MIDDLE AGED; MOLECULAR GENETICS; NEUROENDOCRINE TUMOR; PANCREAS ISLET CELL CARCINOMA; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY;

ADULT; AGED; ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; CARCINOMA, ISLET CELL; CELL DIFFERENTIATION; DNA PRIMERS; FEMALE; HEAD AND NECK NEOPLASMS; HUMANS; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; NEUROENDOCRINE TUMORS; PROTEIN ISOFORMS; RECEPTOR, IGF TYPE 1; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, NEOPLASM; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 33744976345     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.15.5.1249     Document Type: Article

References (19)

1. Ullrich A, Gray A, Tam AW, Yang-Feng T, Tsubokawa M, Collins C, Henzel W, Le Bon T, Kathuria S, Chen E, et al: Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity. EMBO J 5: 2503-2512, 1986.
2. Sekharam M, Zhao H, Sun M, Fang Q, Zhang Q, Yuan Z, Dan HC, Boulware D, Cheng JQ and Coppola D: Insulin-like growth factor 1 receptor enhances invasion and induces resistance to apoptosis of colon cancer cells through the Akt/Bcl-x(L) pathway. Cancer Res 63: 7708-7716, 2003. (Pubitemid 37466701)
3. Hakam A, Yeatman TJ, Lu L, Mora L, Marcet G, Nicosia SV, Karl RC and Coppola D: Expression of insulin-like growth factor-1 receptor in human colorectal cancer. Hum Pathol 30: 1128-1133, 1999. (Pubitemid 29480878)
4. Long L, Rubin R, Baserga R and Brodt P: Loss of the metastatic phenotype in murine carcinoma cells expressing an antisense RNA to the insulin-like growth factor receptor. Cancer Res 55: 1006-1009, 1995.
5. Trojan J, Johnson TR, Rudin SD, Ilan J, Tykocinski M and Ilan J: Treatment and prevention of rat glioblastoma by immunogenic C6 cells expressing antisense insulin-like growth factor I RNA. Science 259: 94-97, 1993. (Pubitemid 23036094)
6. Ambrose D, Resnicoff M, Coppola D, Sell C, Miura C, Jameson S, Baserga R and Rubin R: Growth regulation of human glioblastoma T98G cells by insulin-like growth factor-1 and its receptor. J Cell Physiol 159: 92-100, 1994. (Pubitemid 24234581)
7. Pietrzkoski Z, Mulholland G, Gomella L, Jameson BA, Wernicke D and Baserga R: Inhibition of growth of prostatic cancer cell lines by peptide analogues of insulin-like growth factor 1. Cancer Res 53: 1102-1106, 1993. (Pubitemid 23087914)
8. Resnicoff M, Ambrose D, Coppola D and Rubin R: Insulin-like growth factor-1 and its receptor mediate the autocrine proliferation of human ovarian carcinoma cell lines. Lab Invest 69: 756-760, 1993. (Pubitemid 24026857)
9. Resnicoff M, Coppola D, Sell C, Rubini R, Ferrone S and Baserga R: Growth inhibition of human melanoma cells in nude mice by antisense strategies to the type 1 insulin-like growth factor receptor. Cancer Res 54: 4848-4850, 1994. (Pubitemid 24289413)
10. Adachi Y, Lee CT, Coffee K, Yamagata N, Ohm JE, Park KH, Dikov MM, Nadaf SR, Arteaga CL and Carbone DP: Effects of genetic blockade of the insulin-like growth factor receptor in human colon cancer cell lines. Gastroenterology 123: 1191-1204, 2002.
11. Von Wichert G, Jehle PM, Hoeflich A, Koschnick S, Dralle H, Wolf E, Wiedenmann B, Boehm BO, Adler G and Seufferlein T: Insulin-like growth factor-I is an autocrine regulator of chromogranin A secretion and growth in human neuroendocrine tumor cells. Cancer Res 60: 4573-4581, 2000. (Pubitemid 32103642)
12. Van Gompel JJ and Chen H: Insulin-like growth factor 1 signaling in human gastrointestinal carcinoid tumor cells. Surgery 136: 1297-1302, 2004. (Pubitemid 39647548)
13. Wulbrand U, Remmert G, Zofel P, Wied M, Arnold R and Fehmann HC: mRNA expression patterns of insulin-like growth factor system components in human neuroendocrine tumours. Eur J Clin Invest 30: 729-739, 2000. (Pubitemid 30604075)
14. Condorelli G, Bueno R and Smith RJ: Two alternatively spliced forms of the human insulin-like growth factor I receptor have distinct biological activities and internalization kinetics. J Biol Chem 269: 8510-8516, 1994. (Pubitemid 24200276)
15. Engels WR: Contributing software to the internet: the Amplify program. Trends Biochem Sci 18: 448-450, 1993.
16. Sharrocks AD: The design of primer for PCR. In: PCR Technology - Current Innovations. Griffin HG, Griffin AM (eds). CRC Press, Boca Raton, pp5-11, 1994.
17. Hiller M, Huse K, Szafranski K, Jahn N, Hampe J, Schreiber S, Backofen R and Platzer M: Widespread occurrence of alternative splicing at NAGNAG acceptors contributes to proteome plasticity. Nat Genet 36: 1255-1257, 2004. Erratum in: Nat Genet 37:106, 2005. (Pubitemid 39577932)
18. Day R and Salzet M: The neuroendocrine phenotype, cellular plasticity, and the search for genetic switches: redefining the diffuse neuroendocrine system. Neuroendocrinol Lett 23: 447-451, 2002. (Pubitemid 36050024)
19. Pedrini MT, Giorgino F and Smith RJ: cDNA cloning of the rat IGF I receptors: structural analysis of rat and human IGF I and insulin receptors reveals differences in alternative splicing and receptor-specific domain conservation. Biochem Biophys Res Commun 202: 1038-1046, 1994. (Pubitemid 24259317)