A practical approach for spiro- and 5-monoalkylated barbituric acids

Journal of Heterocyclic Chemistry

Volumn 43, Issue 3, 2006, Pages 607-612

  Singh, Palwinder ^a   Paul, Kamaldeep ^a  

^a GURU NANAK DEV UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

1,3 DIMETHYL 5 (2 PHENYLSULFANYLETHYL) 1H PYRAMIDINE 2,4,6 TRIONE; 5 [2 (2 HYDROXYETHYLSULFANYL)ETHYL] 1,3 DIMETHYLPYRIMIDINE 2,4,6 TRIONE; 5,7 DIAZASPIRO[2.5]OCTANE 4,6,8 TRIONE; ALKYL GROUP; BARBITURIC ACID DERIVATIVE; CARBON; HALIDE; N,N DIMETHYLFORMAMIDE; POTASSIUM CARBONATE; SODIUM CYANIDE; SPIRO COMPOUND; TETRABUTYLAMMONIUM; THYMIDYLATE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CATALYSIS; CATALYST; DRUG ISOLATION; DRUG STRUCTURE; DRUG SYNTHESIS; MELTING POINT; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; RING OPENING; STRUCTURE ANALYSIS;

EID: 33744966879     PISSN: 0022152X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jhet.5570430313     Document Type: Article

References (20)

1. [1a] A. R. Katritzky, C. W. Rees, Comprehensive Heterocyclic Chemistry, 3, 105 (1984);
2. [b] C. K. Cain, J. Kleis, J. Med. Pharm. Chem., 1, 31 (1959) and references cited therein.
3. [2a] L. A. Paquette, R. T. Bibart, C. U. Seekamp, A. L. Kahane, Org. Lett., 3, 4039 (2001);
4. [b] M. Meldgaard, J. Wengel, J. Chem. Soc., Perkin Trans-I, 3539 (2000).
5. A. N. Osman, M. M. Kandeel, M. M. Said, E. M. Ahmad, Indian J. Chem., 35B, 1073 (1996).
6. A. C. Cope, P. Kovacic, M. Burg, J. Am. Chem. Soc., 71, 3658 (1949).
7. W. Fraser, C. J. Suckling, H. C. S. Wood, J. Chem. Soc., Perkin Trans-I, 11, 3137 (1990).
8. A. Renard, J. Lhomme, M. Kotera, J. Org. Chem., 67, 1302-1307 (2002).
9. R. H. McKoown, R. J. Prankerd, J. Chem. Soc., Perkin Trans-II, 481 (1981).
10. A. C. Cope, D. Heyl, D. Peck, C. Eide, A. Arroyo, J. Am. Chem. Soc., 63, 356 (1941).
11. D. J. Guerin, D. Mazeas, M. S. Musale, F. N. M. Naguib, O. N. Al. Safarjalani, M. H. Kouni, R. P. Panzica, Bioorg. Med. Chem. Lett., 9, 1477 (1999) and references cited therein.
12. D. M. Neumann, B. S. Jursic, K. L. Martin, Tetrahedron Lett., 43, 1603 (2002).
13. M. M. A. El Zoorab, M. A. Mogib, Tetrahedron, 52, 10147 (1996).
14. [12a] E. T. da Silva, E. L. S. Lima, Tetrahedron Lett., 44, 3621 (2003);
15. [b] B. S. Jursic, D. M. Neumann, Tetrahedron Lett., 42, 4103 (2001);
16. [c] B. S Jursic, E. D. Stevens, Tetrahedron Lett., 44, 2203 (2003);
17. [d] B. S. Jursic, D. M. Neumann, Tetrahedron Lett., 42, 8435 (2001).
18. M. V. Jovanovic, E. R. Biehl, J. Heterocycl. Chem., 24, 191 (1987).
19. H. H. Zoorob, M. A. Ismail, J. Heterocyclic Chem., 38, 359 (2001).
20. A. R. Katritzky, C. W. Rees, Comprehensive Heterocyclic Chemistry, 3, 68 (1984).