ApoE genotypes: Risk factor for Alzheimer's Disease

Journal, Indian Academy of Clinical Medicine

Volumn 7, Issue 2, 2006, Pages 118-122

  Kapur, Suman ^a   Sharad, Shashwat ^a   Kapoor, Manav ^a   Bala, Kiran ^b  

^a BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE   (India)

^b INSTITUTE OF HUMAN BEHAVIOUR AND ALLIED SCIENCES   (India)

Author keywords

Alzheimer's disease; ApoE genotype; LDL cholesterol; Risk allele genotype

Indexed keywords

APOLIPOPROTEIN E; CHOLESTEROL; LIPID; LOW DENSITY LIPOPROTEIN;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; GENE FREQUENCY; GENOTYPE; HUMAN; INDIAN; MALE; MONOZYGOTIC TWINS; POLYMERASE CHAIN REACTION; PROTEIN LOCALIZATION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RISK FACTOR; SURVIVAL;

EID: 33744942354     PISSN: 09723560     EISSN: 09723560     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Parasuraman R, Greenwood PM, Sunderland T et al. The apolipoprotein E gene, attention and brain function. Neuropsychology 2002; 16 (2): 254-74.
2. Nathan BP, Bellosta S, Sanan DA et al. Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro. Science 1994; 264 (5160): 850-2.
3. Meyer MR, Tschanz JT, Norton MC et al. ApoE genotype predicts when - not whether - one is predisposed to develop Alzheimer disease. Nature Genetics 1998; 19: 321-2.
4. Mahley RW, Huang Y. Apolipoprotein E: from atherosclerosis to Alzheimer's disease and beyond. Curr Opin Lipidol 1999; 10: 207-17.
5. Seshadri S, Drachman DA, Lippa CF. Apolipoprotein E4 allele and the lifetime risk of Alzheimer's disease. Arch Neurol 1995; 52: 1074-9.
6. Assmann G, Funke H, Jabs HU. Analytical procedures for the detection and characterisation of apolipoprotein E mutants. Am Heart J 1987; 113 (2 Pt 2): 598-603.
7. Kölsch H, Lütjohann D, Tulke A et al. The neurotoxic effect of 24-hydroxycholesterol on SHSY5Y human neuroblastoma cells. Brain Res 1999; 818: 171-5.
8. Thelma BK, Juyal RC, Dodge HH et al. ApoE polymorphism in a rural older population-based sample in India. Hum Biol 2001; 73 (1): 135-44.
9. American Psychiatric Association. Diagnostic and statistical manual of mental disorders DSM IV-TR (text Revision). American Psychiatric Press, Washington, DC, 1994.
10. Hammond JB, Spanswick G, Mawn JA. Extraction of DNA from preserved animal specimens for use in randomly amplified polymorphic DNA analysis. Anal Biochem 1996; 240 (2): 298-300.
11. Laws SM, Hone E, Gandy S, Martins RN. Expanding the association between the ApoE gene and the risk of Alzheimer's disease: possible roles for ApoE promoter polymorphisms and alterations in ApoE transcription. J Neurochem 2003; 84 (6): 1215-36.
12. Pansari K, Gupta A, Thomas P. Alzheimer's disease and vascular factors: facts and theories. Int J Clin Pract 2002; 56 (3): 197-203.
13. Bertram L, McQueen M, Mullin K et al. The AlzGene Database. Alzheimer Research Forum. Available at: http://www.alzgene.org. Accessed on 22 October, 2005.
14. Nunomura A, Perry G, Aliev G. Oxidative damage is the earliest event in Alzheimer's disease. Journal of Neuropathology and Experimental Neurology 2001; 60 (8): 759-67.
15. Horsburgh K, Cole GM, Yang F et al. Beta-amyloid (Abeta) 42 (43), abeta42, abeta40 and apoE immunostaining of plaques in fatal head injury. Neuropathol Appl Neurobiol 2000; 26 (2): 124-32.