Correlation of haloperidol levels between submandibular saliva and brain in the rat

Archives of Oral Biology

Volumn 51, Issue 7, 2006, Pages 567-572

  Takai, Noriyasu ^a   Eto, Kenji ^a   Uchihashi, Kenji ^a   Yamaguchi, Masaki ^b   Nishikawa, Yasuo ^a  

^a OSAKA DENTAL UNIVERSITY   (Japan)

^b UNIVERSITY OF TOYAMA   (Japan)

Author keywords

Brain; Haloperidol; Plasma; Rat; Submandibular saliva

Indexed keywords

HALOPERIDOL; NEUROLEPTIC AGENT;

ANIMAL; ARTICLE; BLOOD; BRAIN LEVEL; CHEMISTRY; DRUG EFFECT; MALE; RAT; SALIVA; SALIVATION; SUBMANDIBULAR GLAND; WISTAR RAT;

ANIMALS; ANTIPSYCHOTIC AGENTS; BRAIN CHEMISTRY; HALOPERIDOL; MALE; RATS; RATS, WISTAR; SALIVA; SALIVATION; SUBMANDIBULAR GLAND;

CHORDA;

EID: 33744939986     PISSN: 00039969     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.archoralbio.2005.12.002     Document Type: Article

References (21)

1. Horning M.G., Brown L., Nowlin J., Lertratanangkoon K., Kellaway P., and Zion T.E. Use of saliva in therapeutic dug monitoring. Clin Chem 23 (1977) 157-164
2. Drobitch R.K., and Svensson C.K. Therapeutic drug monitoring in saliva an update. Clin Pharmacokinet 23 (1992) 365-379
3. Liu H., and Delgado M.R. Therapeutic drug concentration monitoring using saliva samples focus on anticonvulsants. Clin Pharmacokinet 36 (1999) 453-470
4. Aps J.K., and Martens L.C. Review: the physiology of saliva and transfer of drugs into saliva. Forensic Sci Int 150 (2005) 119-131
5. Lawson G.M. Monitoring of serum haloperidol. Mayo Clin Proc 69 (1994) 189-190
6. Eilers R. Therapeutic drug monitoring for the treatment of psychiatric disorders clinical use and cost effectiveness. Clin Pharmacokinet 29 (1995) 442-450
7. Kudo S., and Ishizaki T. Pharmacokinetics of haloperidol: an update. Clin Pharmacokinet 37 (1999) 435-456
8. Yamazumi S., and Miura S. Haloperidol concentrations in saliva and serum: determination by the radioimmunoassay method. Int Pharmacopsychiatry 16 (1981) 174-183
9. Dysken M.W., Johnson S.B., Holden L., Kuskowski M., Ofstehage J., Skare S., et al. Haloperidol and reduced haloperidol in saliva and blood. J Clin Psychopharmacol 12 (1992) 186-190
10. Zohar J., Birmaher B., Schoenfeld H., and Belmaker R.B. Salivary and blood levels of neuroleptics during outpatient maintenance treatment. Isr J Psychiatry Relat Sci 23 (1986) 123-128
11. Creese I., Burt D.R., and Snyder S.H. Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs. Science 192 (1976) 481-483
12. Takai N., Yoshida Y., and Kakudo Y. Secretion and re-absorption of glucose in rat submandibular and sublingual saliva. J Dent Res 62 (1983) 1022-1025
13. Takai N., Yoshida Y., Shida T., Kondo E., Ueda Y., Kiyama H., et al. Expression of vasoactive intestinal polypeptide receptor mRNA and secretory regulation by vasoactive intestinal polypeptide in rat submandibular and sublingual salivary glands. Arch Oral Biol 42 (1997) 197-204
14. Jusko W.J., and Milsap R.L. Pharmacokinetic principles of drug distribution in saliva. Ann NY Acad Sci 694 (1993) 36-47
15. Magliozzi J.R., Hollister L.E., Arnold K.V., and Earle G.M. Relationship of serum haloperidol levels to clinical response in schizophrenic patients. Am J Psychiatry 138 (1981) 365-367
16. Öhman R., Larsson M., Nilsson I.M., Engel J., and Carlsson A. Neurometabolic and behavioural effects of haloperidol in relation to drug levels in serum and brain. Naunyn Schmiedeberg Arch Pharmacol 299 (1977) 105-114
17. Spector R. Drug transport in the mammalian central nervous system: multiple complex systems a critical analysis and commentary. Pharmacology 60 (2000) 58-73
18. Stephen K.W., McCrossan J., Mackenzie D., Macfarlane C.B., and Speirs C.F. Factors determining the passage of drugs from blood into saliva. Br J Clin Pharmacol 9 (1980) 51-55
19. Haeckel R., and Hanecke P. Application saliva for drug monitoring an in vitro model for transmembrane transport. Eur J Clin Chem Clin Biochem 34 (1996) 171-191
20. Garrett JR. Movement of organic molecules from blood to saliva and from glands to blood. In: Garrett J.R., Ekström J., and Anderson L.C. (Eds). Glandular mechanisms of salivary secretion. Front Oral Biol vol. 10 (1998), Karger, Basel 153-166
21. Mazariegos M.R., Tice L.W., and Hand A.R. Alteration of tight junctional permeability in the rat parotid gland after isoproterenol stimulation. J Cell Biol 98 (1984) 1865-1877