Jaundice and alpha gene triplication in beta-thalassemia: Association or causation?

Hematology

Volumn 11, Issue 2, 2006, Pages 109-112

  Panigrahi, Inusha ^a   Mahapatra, Manoranjan ^a   Kumar, Rajat ^a   Kumar, Guresh ^a   Choudhry Ved, Prakash ^a   Saxena, Renu ^a  

^a INSTITUTE ROTARY CANCER HOSPITAL   (India)

Author keywords

Alpha anti 3.7 triplication; Alpha gene deletions; Jaundice; Molecular analysis; Thalassaemia intermedia

Indexed keywords

ALPHA GLOBIN; BILIRUBIN; HEMOGLOBIN; HEMOGLOBIN F; PREDNISOLONE;

ADOLESCENT; ADULT; ARTICLE; ASIAN; BETA THALASSEMIA; CLINICAL FEATURE; CONTROLLED STUDY; COOMBS POSITIVE HEMOLYTIC ANEMIA; DISEASE ASSOCIATION; DISEASE SEVERITY; ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY; FEMALE; GENE IDENTIFICATION; GENE REPLICATION; GENETIC SCREENING; HEMOGLOBIN DETERMINATION; HETEROZYGOSITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HOMOZYGOSITY; HUMAN; INDIAN; JAUNDICE; LIVER FUNCTION TEST; MAJOR CLINICAL STUDY; MALE; PATHOPHYSIOLOGY; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

ADOLESCENT; ADULT; ANEMIA, HEMOLYTIC; BETA-THALASSEMIA; CHILD; FEMALE; FETAL HEMOGLOBIN; GENE AMPLIFICATION; GENOTYPE; GLOBINS; HEMOGLOBIN A2; HUMANS; INDIA; MALE;

EID: 33744933206     PISSN: 10245332     EISSN: 16078454     Source Type: Journal    
DOI: 10.1080/1024533050069882     Document Type: Article

References (12)

1. Higgs, DR and Thein, SL and Wood, WG.(2001) Distribution and population genetics of the thalassemias. In The thalassemia syndromes4th ed. (pp. 237-284). Oxford: Blackwell Science.
2. Smetanina, NS and Huisman, TH. (1996) Detection of α-thalassemia-2 (-3.7 kb) and its corresponding triplication (α)(α)(α) (anti-3.7 kb) by PCR: An improved technical change Am J Hematol, 53, pp. 202-203.
3. Liu, YT and Old, JM and Miles, K and Fisher, CA and Weatherall, DJ and Clegg, JB. (2000) Rapid detection of alpha-thalassaemia deletions and alpha-globin gene triplication by multiplex polymerase chain reactions Br J Haematol, 108, pp. 295-299.
4. Rees, DC and Singh, BM and Luo, LY and Wickramasinghe, S and Thein, SL. (1998) Nontransfusional iron overload in thalassemia. Association with hereditary hemochromatosis Ann NY Acad Sci, 850, pp. 490-494.
5. 3.7) or deletion (-α3.7/) association in Argentinian β-thalassemic carriers Ann Hematol, 82, pp. 696-698.
6. Agarwal, S and Sarwai, S and Nigam, N and Singhal, P. (2002) Rapid detection of alpha+thalassemia deletion and α globin gene triplication by Gap-PCR in Indian subjects Ind J Med Res, 116, pp. 155-161.
7. Trehan, U and Garewal, G and Kaul, D and Das, R. (2001) Molecular pathology of thalassemia and triplicated locus in North Indians; interaction with heterozygous thalassemia Hematology, 6, pp. 153-160.
8. Panigrahi, I and Rafeeq, PHA and Choudhry, VP and Saxena, R. (2004) High frequency of deletional alpha thalassemia in β-thalassemia trait: Implications for genetic counseling Am J Hematol, 76, pp. 297-299.
9. Bianco, I and Lerone, M and Foglietta, E and Deidda, G and Cappabianca, MP and Morlupi, L and Ponzini, D and Grisanti, P and Di Biagio, P and Amato, A and Mezzabotta, M and Graziani, B. (1997) Phenotypes of individuals with a β thal classical allele associated either with a β thal silent allele or with α globin gene triplication Haematologica, 82, pp. 513-525.
10. Ma, SK and Au, WY and Chan, AY and Chan, LC. (2001) Clinical phenotype of triplicated α-globin genes and heterozygosity for β-0-thalassemia in Chinese subjects Int J Mol Med, 8, pp. 171-175.
11. Kanavakis, E and Metaxotou-Mavromati, A and Kattamis, C and Wainscoat, JS and Wood, WG. (1983) The triplicated α gene locus and beta thalassemia Br J Haematol, 54, pp. 201-207.
12. Henni, T and Belhani, M and Morle, F and Bachir, D and Tabone, P and Colonna, P and Godet, J. (1985) α globin gene triplication in severe heterozygous β-thalassemia Acta Haematol, 74, pp. 236-239.