TGF-β1/SMAD signaling pathway mediates p53-dependent apoptosis in hepatoma cell lines

Chinese Medical Sciences Journal

Volumn 21, Issue 1, 2006, Pages 33-35

  Wang, Chun Lei ^a   Wan, Yuan Lian ^a   Liu, Yu Cun ^a   Huang, Zhi Qiang ^b  

^a PEKING UNIVERSITY   (China)

^b CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

Apoptosis; Hepatoma cell line; Signal transduction pathway; Transforming growth factor 1

Indexed keywords

LYMPHOTOXIN; PROTEIN P53; SMAD PROTEIN; LUCIFERASE; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

APOPTOSIS; ARTICLE; CARCINOMA CELL; ENZYME ACTIVITY; GENETIC TRANSFECTION; HEPATOMA CELL; HUMAN; HUMAN CELL; NICK END LABELING; SIGNAL TRANSDUCTION; DRUG EFFECT; GENETICS; LIVER CELL CARCINOMA; LIVER TUMOR; METABOLISM; PATHOLOGY; PLASMID; REPORTER GENE; TUMOR CELL LINE; TUMOR SUPPRESSOR GENE;

APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; GENES, P53; GENES, REPORTER; HUMANS; LIVER NEOPLASMS; LUCIFERASES; PLASMIDS; SIGNAL TRANSDUCTION; SMAD4 PROTEIN; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA1;

EID: 33744923207     PISSN: 10019294     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

1. EL-Serag HB, Mason AC, Key C. Trends in survival of patients with hepatocellular carcinoma between 1977 and 1966 in the linked States. Hepatology 2001; 33: 62-5.
2. Choi KS, Eom YW, Kang Y, et al. Cdc2 and Cdk2 kinase activated by TGF-β trigger apoptosis through the phosphorylation of retinoblastoma protein in FaO hepatoma cells. J Biol Chem 1999; 274: 31775-83.
3. Galle PR. Apoptosis in liver disease. J Hepatol 1997; 27: 405-12.
4. Hupp TR, Lane DP, Ball KL. Strategies for manipulating the p53 pathway in the treatment of human cancer. Biochem J 2000; 352: 1-17.
5. Wrana JL. Regulation of Smad activity. Cell 2000; 100: 189-92.
6. Massague J, Blain SW, Lo RS. TGF beta signaling in growth control, cancer, and heritable disorders. Cell 2000; 103: 295-309.
7. de Winter JP, Roelen BA, ten Dijke P, et al. Dpc4 (SMAD4) mediated transforming growth factor-1 induced growth inhibition and transcriptional response in breast tumor cells. Oncogene 1997; 14: 1891-9.