Aldosterone, ion channels, and sudden death: Another piece of the circle?

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 290, Issue 6, 2006, Pages

  Pitt, Geoffrey S ^a,d   Pitt, Bertram ^b,c  

^a Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c WILLIAM BEAUMONT HOSPITAL   (United States)

^d Howard Hughes Medical Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSTERONE; INWARDLY RECTIFYING POTASSIUM CHANNEL; ION CHANNEL; MINERALOCORTICOID RECEPTOR; POTASSIUM CHANNEL HERG; SODIUM CHANNEL;

ARRHYTHMOGENESIS; EDITORIAL; GENE EXPRESSION; GENE MUTATION; HEART ARRHYTHMIA; HEART BUNDLE BRANCH BLOCK; HEART CONDUCTION; HEART FUNCTION; HEART MUSCLE CELL; HISTOPATHOLOGY; KNOCKOUT GENE; MEDICAL LITERATURE; NONHUMAN; PRIORITY JOURNAL; QT PROLONGATION; REPOLARIZATION; SUDDEN DEATH;

ALDOSTERONE; ANIMALS; DEATH, SUDDEN, CARDIAC; ION CHANNEL GATING; ION CHANNELS; MICE; MICE, KNOCKOUT; SODIUM CHANNELS;

EID: 33744919265     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00186.2006     Document Type: Editorial

References (23)

1. Antzelevitch C, Brugada P, Borggrefe M, Brugada J, Brugada R, Corrado D, Gussak I, LeMarec H, Nademanee K, Perez Riera AR, Shimizu W, Schulze-Bahr E, Tan H, and Wilde A. Brugada Syndrome: report of the Second Consensus Conference: endorsed by the Heart Rhythm Society and the European Heart Rhythm Association. Circulation 111: 659-670, 2005.
2. Barr CS, Lang CC, Hanson J, Arnott M, Kennedy N, and Struthers AD. Effects of adding spironolactone to an angiotensin-converting enzyme inhibitor in chronic congestive heart failure secondary to coronary artery disease. Am J Cardiol 76: 1259-1265, 1995.
3. Barr CS, Naas A, Freeman M, Lang CC, and Struthers AD. QT dispersion and sudden unexpected death in chronic heart failure. Lancet 343: 327-329, 1994.
4. Benitah JP, Perrier E, Gomez AM, and Vassort G. Effects of aldosterone on transient outward K+ current density in rat ventricular myocytes. J Physiol 537: 151-160, 2001.
5. Boixel C, Gavillet B, Rougier JS, and Abriel H. Aldosterone increases voltage-gated sodium current in ventricular myocytes. Am J Physiol Heart Circ Physiol 290: H2257-H2266, 2006.
6. Coronel R, Casini S, Koopmann TT, Wilms-Schopman FJG, Verkerk AO, de Groot JR, Bhuiyan Z, Bezzina CR, Veldkamp MW, Linnenbank AC, van der Wal AC, Tan HL, Brugada P, Wilde AAM, and de Bakker JMT. Right ventricular fibrosis and conduction delay in a patient with clinical signs of Brugada Syndrome: a combined electrophysiological, genetic, histopathologic, and computational study. Circulation 112: 2769-2777, 2005.
7. Francis J, Weiss RM, Wei SG, Johnson AK, Beltz TG, Zimmerman K, and Felder RB. Central mineralocorticoid receptor blockade improves volume regulation and reduces sympathetic drive in heart failure. Am J Physiol Heart Circ Physiol 281: H2241-H2251, 2001.
8. George AL Jr. Inherited disorders of voltage-gated sodium channels. J Clin Invest 115: 1990-1999, 2005.
9. Kleber AG and Rudy Y. Basic mechanisms of cardiac impulse propagation and associated arrhythmias. Physiol Rev 84: 431-488, 2004.
10. Le Menuet D, Isnard R, Bichara M, Viengchareun S, Muffat-Joly M, Walker F, Zennaro MC, and Lombes M. Alteration of cardiac and renal functions in transgenic mice overexpressing human mineralocorticoid receptor. J Biol Chem 276: 38911-38920, 2001.
11. Olson TM, Michels VV, Ballew JD, Reyna SP, Karst ML, Herron KJ, Horton SC, Rodeheffer RJ, and Anderson JL. Sodium channel mutations and susceptibility to heart failure and atrial fibrillation. JAMA 293: 447-454, 2005.
12. Papadatos GA, Wallerstein PMR, Head CEG, Ratcliff R, Brady PA, Benndorf K, Saumarez RC, Trezise AEO, Huang CLH, Vandenberg JI, Colledge WH, and Grace AA. From the cover: slowed conduction and ventricular tachycardia after targeted disruption of the cardiac sodium channel gene Scn5a. PNAS 99: 6210-6215, 2002.
13. 2+ current in mice. J Physiol 569: 153-162, 2005.
14. Pitt B, Remme W, Zannad F, Neaton J, Martinez F, Roniker B, Bittman R, Hurley S, Kleiman J, Gatlin M, and Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study Investigators. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med 348: 1309-1321, 2003.
15. Pitt B, Stier CT Jr, and Rajagopalan S. Mineralocorticoid receptor blockade: new insights into the mechanism of action in patients with cardiovascular disease. J Renin Angiotensin Aldosterone Syst 4: 164-168, 2003.
16. Priori SG, Napolitano C, Gasparini M, Pappone C, Bella PD, Giordano U, Bloise R, Giustetto C, De Nardis R, Grillo M, Ronchetti E, Faggiano G, and Nastoli J. Natural history of Brugada syndrome: insights for risk stratification and management. Circulation 105: 1342-1347, 2002.
17. Roden DM. Drug-induced prolongation of the QT interval. N Engl J Med 350: 1013-1022, 2004.
18. Royer A, van Veen TAB, Le Bouter S, Marionneau C, Griol-Charhbili V, Leoni AL, Steenman M, van Rijen HVM, Demolombe S, Goddard CA, Richer C, Escoubet B, Jarry-Guichard T, Colledge WH, Gros D, de Bakker JMT, Grace AA, Escande D, and Charpentier F. Mouse model of SCN5A-linked hereditary Lenegre's Disease: age-related conduction slowing and myocardial fibrosis. Circulation 111: 1738-1746, 2005.
19. Spargias KS, Lindsay SJ, Kawar GI, Greenwood DC, Cowan JC, Ball SG, and Hall AS. QT dispersion as a predictor of long-term mortality in patients with acute myocardial infarction and clinical evidence of heart failure. Eur Heart J 20: 1158-1165, 1999.
20. Tomaselli GF, Beuckelmann DJ, Calkins HG, Berger RD, Kessler PD, Lawrence JH, Kass D, Feldman AM, and Marban E. Sudden cardiac death in heart failure. The role of abnormal repolarization. Circulation 90: 2534-2539, 1994.
21. van Veen TAB, Stein M, Royer A, Le Quang K, Charpentier F, Colledge WH, Huang CLH, Wilders R, Grace AA, Escande D, de Bakker JMT, and van Rijen HVM. Impaired impulse propagation in Scn5a-knockout mice: combined contribution of excitability, connexin expression, and tissue architecture in relation to aging. Circulation 112: 1927-1935, 2005.
22. Vrtovec B, Delgado R, Zewail A, Thomas CD, Richartz BM, and Radovancevic B. Prolonged QTc interval and high B-type natriuretic peptide levels together predict mortality in patients with advanced heart failure. Circulation 107: 1764-1769, 2003.
23. Yee KM, Pringle SD, and Struthers AD. Circadian variation in the effects of aldosterone blockade on heart rate variability and QT dispersion in congestive heart failure. J Am Coll Cardiol 37: 1800-1807, 2001.