CARMA1 is critical for the development of allergic airway inflammation in a murine model of asthma

Journal of Immunology

Volumn 176, Issue 12, 2006, Pages 7272-7277

  Medoff, Benjamin D ^a   Seed, Brian ^a   Jackobek, Ryan ^a   Zora, Jennifer ^a   Yang, Yi ^a   Luster, Andrew D ^a   Xavier, Ramnik ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; PROTEIN CARMA1; SCAFFOLD PROTEIN; UNCLASSIFIED DRUG;

ADOPTIVE TRANSFER; ALLERGY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN SPECIFICITY; ARTICLE; ASTHMA; BRONCHUS HYPERREACTIVITY; CARMA1 GENE; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG TARGETING; GENE; GENE DELETION; HISTOPATHOLOGY; IMMUNE RESPONSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY TRACT INFLAMMATION; T LYMPHOCYTE ACTIVATION; WILD TYPE;

EID: 33744910592     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.176.12.7272     Document Type: Article

References (34)

1. Bertin, J., L. Wang, Y. Guo, M. D. Jacobson, J. L. Poyet, S. M. Srinivasula, S. Merriam, P. S. DiStefano, and E. S. Alnemri. 2001. CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-κB. J. Biol. Chem. 276: 11877-11882.
2. Gaide, O., F. Martinon, O. Micheau, D. Bonnet, M. Thome, and J. Tschopp. 2001. Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-κB activation. FEBS Lett. 496: 121-127.
3. Hara, H., T. Wada, C. Bakal, I. Kozieradzki, S. Suzuki, N. Suzuki, M. Nghiem, E. K. Griffiths, C. Krawczyk, B. Bauer, et al. 2003. The MAGUK family protein CARD11 is essential for lymphocyte activation. Immunity 18: 763-775.
4. Pomerantz, J. L., E. M. Denny, and D. Baltimore. 2002. CARD11 mediates factor-specific activation of NF-κB by the T cell receptor complex. EMBO J. 21: 5184-5194.
5. Wang, D., Y. You, S. M. Case, L. M. McAllister-Lucas, L. Wang, P. S. DiStefano, G. Nunez, J. Bertin, and X. Lin. 2002. A requirement for CARMA1 in TCR-induced NF-κB activation. Nat. Immunol. 3: 830-835.
6. Li, Q., and I. M. Verma. 2002. NF-κB regulation in the immune system. Nat. Rev. Immunol. 2: 725-734.
7. Thome, M. 2004. CARMA1, BCL-10 and MALT1 in lymphocyte development and activation. Nat. Rev. Immunol. 4: 348-359.
8. Hayden, M. S., and S. Ghosh. 2004. Signaling to NF-κB. Genes Dev. 18: 2195-2224.
9. Egawa, T., B. Albrecht, B. Favier, M. J. Sunshine, K. Mirchandani, W. O'Brien, M. Thome, and D. R. Littman. 2003. Requirement for CARMA1 in antigen receptor-induced NF-κB activation and lymphocyte proliferation. Curr. Biol. 13: 1252-1258.
10. Matsumoto, R., D. Wang, M. Blonska, H. Li, M. Kobayashi, B. Pappu, Y. Chen, D. Wang, and X. Lin. 2005. Phosphorylation of CARMA1 plays a critical role in T cell receptor-mediated NF-κB activation. Immunity 23: 575-585.
11. Sommer, K., B. Guo, J. L. Pomerantz, A. D. Bandaranayake, M. E. Moreno-Garcia, Y. L. Ovechkina, and D. J. Rawlings. 2005. Phosphorylation of the CARMA1 linker controls NF-κB activation. Immunity 23: 561-574.
12. Khoshnan, A., D. Bae, C. A. Tindell, and A. E. Nel. 2000. The physical association of protein kinase Cθ with a lipid raft-associated inhibitor of κB factor kinase (IKK) complex plays a role in the activation of the NF-κB cascade by TCR and CD28. J. Immunol. 165: 6933-6940.
13. Weil, R., K. Schwamborn, A. Alcover, C. Bessia, V. Di Bartolo, and A. Israel. 2003. Induction of the NF-κB cascade by recruitment of the scaffold molecule NEMO to the T cell receptor. Immunity 18: 13-26.
14. Hara, H., C. Bakal, T. Wada, D. Bouchard, R. Rottapel, T. Saito, and J. M. Penninger. 2004. The molecular adapter Carma1 controls entry of IκB kinase into the central immune synapse. J. Exp. Med. 200: 1167-1177.
15. Jun, J. E., L. E. Wilson, C. G. Vinuesa, S. Lesage, M. Blery, L. A. Miosge, M. C. Cook, E. M. Kucharska, H. Hara, J. M. Penninger, et al. 2003. Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis. Immunity 18: 751-762.
16. Donovan, C. E., D. A. Mark, H. Z. He, H. C. Liou, L. Kobzik, Y. Wang, G. T. De Sanctis, D. L. Perkins, and P. W. Finn. 1999. NF-κB/Rel transcription factors: c-Rel promotes airway hyperresponsiveness and allergic pulmonary inflammation. J. Immunol. 163: 6827-6833.
17. Yang, L., L. Cohn, D. H. Zhang, R. Homer, A. Ray, and P. Ray. 1998. Essential role of nuclear factor κB in the induction of eosinophilia in allergic airway inflammation. J. Exp. Med. 188: 1739-1750.
18. Das, J., C. H. Chen, L. Yang, L. Cohn, P. Ray, and A. Ray. 2001. A critical role for NF-κB in GATA3 expression and TH2 differentiation in allergic airway inflammation. Nat. Immunol. 2: 45-50.
19. Desmet, C., P. Gosset, B. Pajak, D. Cataldo, M. Bentires-Alj, P. Lekeux, and F. Bureau. 2004. Selective blockade of NF-κB activity in airway immune cells inhibits the effector phase of experimental asthma. J. Immunol. 173: 5766-5775.
20. Poynter, M. E., R. Cloots, T. van Woerkom, K. J. Butnor, P. Vacek, D. J. Taatjes, C. G. Irvin, and Y. M. Janssen-Heininger. 2004. NF-κ activation in airways modulates allergic inflammation but not hyperresponsiveness. J. Immunol. 173: 7003-7009.
21. Broide, D. H., T. Lawrence, T. Doherty, J. Y. Cho, M. Miller, K. McElwain, S. McElwain, and M. Karin. 2005. Allergen-induced peribronchial fibrosis and mucus production mediated by IκB kinase β-dependent genes in airway epithelium. Proc. Natl. Acad. Sci. USA 102: 17723-17728.
22. Yang, Y., and B. Seed. 2003. Site-specific gene targeting in mouse embryonic stem cells with intact bacterial artificial chromosomes. Nat. Biotechnol. 21: 447-451.
23. Medoff, B. D., A. M. Tager, R. Jackobek, T. K. Means, L. Wang, and A. D. Luster. 2006. Antibody-antigen interaction in the airway drives early granulocyte recruitment through BLT1. Am. J. Physiol. 290: L170-L178.
24. Tager, A. M., S. K. Bromley, B. D. Medoff, S. A. Islam, S. D. Bercury, E. B. Friedrich, A. D. Carafone, R. E. Gerszten, and A. D. Luster. 2003. Leukotriene B4 receptor BLT1 mediates early effector T cell recruitment. Nat. Immunol. 4: 982-990.
25. Revets, H., G. Pynaert, J. Grooten, and P. De Baetselier. 2005. Lipoprotein 1, a TLR2/4 ligand modulates Th2-driven allergic immune responses. J. Immunol. 174: 1097-1103.
26. Mathew, A., B. D. Medoff, A. D. Carafone, and A. D. Luster. 2002. Cutting edge: Th2 cell trafficking into the allergic lung is dependent on chemoattractant receptor signaling. J. Immunol. 169: 651-655.
27. MacLean, J. A., R. Ownbey, and A. D. Luster. 1996. T cell-dependent regulation of eotaxin in antigen-induced pulmonary eosinophila. J. Exp. Med. 184: 1461-1469.
28. + T cells to the lung during influenza pneumonia. J. Immunol. 167: 6983-6990.
29. Takeda, K., A. Haczku, J. J. Lee, C. G. Irvin, and E. W. Gelfand. 2001. Strain dependence of airway hyperresponsiveness reflects differences in eosinophil localization in the lung. Am. J. Physiol. 281: L394-L402.
30. Rueda, D., and M. Thome. 2005. Phosphorylation of CARMA1: the link(er) to NF-κB activation. Immunity 23: 551-555.
31. Gonzalo, J. A., C. M. Lloyd, L. Kremer, E. Finger, A. C. Martinez, M. H. Siegelman, M. Cybulsky, and J. C. Gutierrez-Ramos. 1996. Eosinophil recruitment to the lung in a murine model of allergic inflammation: the role of T cells, chemokines, and adhesion receptors. J. Clin. Invest, 98: 2332-2345.
32. Bromley, S. K., S. Y. Thomas, and A. D. Luster. 2005. Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics. Nat. Immunol. 6: 895-901.
33. Eisenbarth, S. C., S. Cassel, and K. Bottomly. 2004. Understanding asthma pathogenesis: linking innate and adaptive immunity. Curr. Opin. Pediatr. 16: 659-666.
34. Lin, X., and D. Wang. 2004. The roles of CARMA1, Bcl10, and MALT1 in antigen receptor signaling. Semin. Immunol. 16: 429-435.