Differential uPA expression by TGF-β1 in gingival fibroblasts

Journal of Dental Research

Volumn 85, Issue 2, 2006, Pages 150-155

  Smith, P C ^a   Martinez J ^a  

^a UNIVERSITY OF CHILE   (Chile)

Author keywords

Fibroblast; Gingival; Myofibroblast; TGF 1; Urokinase

Indexed keywords

ACTIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TGFB1 PROTEIN, HUMAN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; UROKINASE;

ADULT; ARTICLE; BIOSYNTHESIS; CASE CONTROL STUDY; CELL CULTURE; CYTOLOGY; FEMALE; FIBROBLAST; GINGIVA; GRANULATION TISSUE; HUMAN; INJURY; MALE; METABOLISM; PERIODONTAL DISEASE; PHYSIOLOGY; SIGNAL TRANSDUCTION; WOUND HEALING;

ACTINS; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADULT; CASE-CONTROL STUDIES; CELLS, CULTURED; FEMALE; FIBROBLASTS; GINGIVA; GRANULATION TISSUE; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MAP KINASE SIGNALING SYSTEM; PERIODONTAL DISEASES; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; URINARY PLASMINOGEN ACTIVATOR; WOUND HEALING;

EID: 33744825704     PISSN: 00220345     EISSN: None     Source Type: Journal    
DOI: 10.1177/154405910608500207     Document Type: Article

References (30)

1. Akhurst RJ, Derynck R (2001). TGF-beta signaling in cancer-a double-edged sword. Trends Cell Biol 11:S44-S51.
2. Andreasen PA, Kjøller L, Christensen L, Duffy MJ (1997). The urokinase-type plasminogen activator system in cancer metastasis: a review. Int J Cancer 72:1-22.
3. Anichini E, Fibbi G, Pucci M, Caldini R, Chevanne M, Del Rosso M (1994). Production of second messengers following chemotactic and mitogenic urokinase-receptor interaction in human fibroblasts and mouse fibroblasts transfected with human urokinase receptor. Exp Cell Res 213:438-448.
4. Arora PD, McCulloch CA (1994). Dependence of collagen remodelling on alpha-smooth muscle actin expression by fibroblasts. J Cell Physiol 159:161-175.
5. Bartold PM, Walsh LJ, Narayanan AS (2000). Molecular and cell biology of the gingiva. Periodontol 2000 24:28-55.
6. Behrendt N (2004). The urokinase receptor (uPAR) and uPAR-associated protein (uPARAP/Endo180): membrane proteins engaged in matrix turnover during tissue remodeling. Biol Chem 385:103-136.
7. Carmeliet P, Schoonjans L, Kieckens L, Ream B, Degen J, Bronson R, et al. (1994). Physiological consequences of loss of plasminogen activator gene function in mice. Nature 368:419-424.
8. Desmoulière A, Darby IA, Gabbiani G (2003). Normal and pathologic soft tissue remodeling: role of the myofibroblast, with special emphasis on liver and kidney fibrosis. Lab Invest 83:1689-1707.
9. Häkkinen L, Larjava H (1992). Characterization of fibroblast clones from periodontal granulation tissue in vitro. J Dent Res 71:1901-1907.
10. Häkkinen L, Westermarck J, Kähäri V-M, Larjava H (1996). Human granulation-tissue fibroblasts show enhanced proteoglycan gene expression and altered response to TGF-β1. J Dent Res 75:1767-1778.
11. 2 production, in human synovial fibroblasts. Proc Natl Acad Sci USA 88:7180-7184.
12. Harbeck N, Kates RE, Gauger K, Willems A, Kiechle M, Magdolen V, et al. (2004). Urokinase-type plasminogen activator (uPA) and its inhibitor PAI-I: novel tumor-derived factors with a high prognostic and predictive impact in breast cancer. Thromb Haemost 91:450-456.
13. Irigoyen JP, Muñoz-Canoves P, Montero L, Koziczak M, Nagamine Y (1999). The plasminogen activator system: biology and regulation. Cell Mol Life Sci 56:104-132.
14. Kinnby B, Lindberg P, Lecander I, Matsson L (1999). Localization of plasminogen activators and plasminogen-activator inhibitors in human gingival tissues demonstrated by immunohistochemistry and in situ hybridization. Arch Oral Biol 44:1027-1034.
15. Kuru L, Griffiths GS, Petrie A, Olsen I (2004). Changes in transforming growth factor-beta 1 in gingival crevicular fluid following periodontal surgery. J Clin Periodontol 31:527-533.
16. Laiho M, Saksela O, Keski-Oja J (1986a). Transforming growth factor beta alters plasminogen activator activity in human skin fibroblasts. Exp Cell Res 164:399-407.
17. Laiho M, Saksela O, Andreasen PA, Keski-Oja J (1986b). Enhanced production and extracellular deposition of the endothelial-type plasminogen activator inhibitor in cultured human lung fibroblasts by transforming growth factor-beta. J Cell Biol 103:2403-2410.
18. Larjava H, Salo T, Haapasalmi K, Kramer RH, Heino J (1993). Expression of integrins and basement membrane components by wound keratinocytes. J Clin Invest 92:1425-1435.
19. Miralles F, Parra M, Caelles C, Nagamine Y, Felez J, Muñoz-Canoves P (1998). UV irradiation induces the murine urokinase-type plasminogen activator gene via the c-Jun N-terminal kinase signaling pathway: requirement of an AP1 enhancer element. Mol Cell Biol 18:4537-4547.
20. Nielsen BS, Sehested M, Timshel S, Pyke C, Danø K (1996). Messenger RNA for urokinase plasminogen activator is expressed in myofibroblasts adjacent to cancer cells in human breast cancer. Lab Invest 74:168-177.
21. Parra M, Lluis F, Miralles F, Caelles C, Muñoz-Cánoves P (2000). The cJun N-terminal kinase (JNK) signaling pathway mediates induction of urokinase-type plasminogen activator (uPA) by the alkylating agent MNNG. Blood 96:1415-1424.
22. Resnati M, Guttinger M, Valmonica S, Sidenius N, Blasi F, Fazioli F (1996). Proteolytic cleavage of the urokinase receptor substitutes for the agonist-induced chemotactic effect. EMBO J 15:1572-1582.
23. Santibáñez JF, Maccioni RB, Martínez J (1995). The secretion of urokinase-like plasminogen activator is inhibited by microtubule-interacting drugs. Cell Biochem Funct 13:217-225.
24. Santibáñez JF, Iglesias M, Frontelo P, Martínez J, Quintanilla M (2000). Involvement of the Ras/MAPK signaling pathway in the modulation of urokinase production and cellular invasiveness by transforming growth factor-beta(1) in transformed keratinocytes. Biochem Biophys Res Commun 273:521-527.
25. Schäfer BM, Maier K, Eickhoff U, Todd RF, Kramer MD (1994). Plasminogen activation in healing human wounds. Am J Pathol 144:1269-1280.
26. Sieuwerts AM, Klijn JG, Henzen-Logmans SC, Foekens JA (1999). Cytokine-regulated urokinase-type-plasminogen-activator (uPA) production by human breast fibroblasts in vitro. Breast Cancer Res Treat 55:9-20.
27. Smith PC, Santibáñez JF, Morales JP, Martinez J (2004). Epidermal growth factor stimulates urokinase-type plasminogen activator expression in human gingival fibroblasts. Possible modulation by genistein and curcumin. J Periodontal Res 39:380-387.
28. Steinsvoll SH, Alstensen TS, Schenck K (1999). Extensive expression of TGF-beta1 in chronically-inflamed periodontal tissue. J Clin Periodontol 26:366-373.
29. Witowsky J, Abell A, Johnson NL, Johnson GL, Cuevas BD (2003). MEKK1 is required for inducible urokinase-type plasminogen activator expression. J Biol Chem 278:5941-5946.
30. Xiao Y, Li H, Bunn C, Bartold PM (2001). The expression of plasminogen activator system in a rat model of periodontal wound healing. J Periodontol 72:849-857.