Amyotrophic lateral sclerosis: New developments in diagnostic markers

Neurodegenerative Diseases

Volumn 2, Issue 3-4, 2006, Pages 177-184

  Dengler, Reinhard ^a   Von Neuhoff, Nils ^a   Bufler, Johannes ^a   Krampfl, Klaus ^a   Peschel, Thomas ^a   Grosskreutz, Julian ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Amyotrophic lateral sclerosis; Diffusion tensor imaging; Magnetic resonance imaging; Proteomics; Transcranial magnetic stimulation

Indexed keywords

BIOCHEMICAL MARKER; BRAIN DERIVED NEUROTROPHIC FACTOR; CILIARY NEUROTROPHIC FACTOR; INTERLEUKIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN NOGO; PROTEIN NOGO A; SOMATOMEDIN; VASCULOTROPIN;

AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CEREBROSPINAL FLUID ANALYSIS; DIAGNOSTIC PROCEDURE; DIFFUSION TENSOR IMAGING; DISEASE COURSE; HUMAN; MASS SPECTROMETRY; MORPHOMETRICS; MOTOR NEURON DISEASE; MOTOR UNIT; NERVE CELL LESION; NERVE DEGENERATION; NEUROIMAGING; NEUROPHYSIOLOGY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEOMICS; TRANSCRANIAL MAGNETIC STIMULATION; TWO DIMENSIONAL GEL ELECTROPHORESIS;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; BIOLOGICAL MARKERS; BRAIN; DIFFUSION MAGNETIC RESONANCE IMAGING; HUMANS; MOTOR NEURONS; PROTEOMICS; TRANSCRANIAL MAGNETIC STIMULATION;

EID: 33744823049     PISSN: 16602854     EISSN: 16602862     Source Type: Journal    
DOI: 10.1159/000089623     Document Type: Article

References (37)

1. Dengler R, Bufler J: Amyotrophic lateral sclerosis and related disorders; in Herdegen T, Delgado-Garcia J (eds): Brain Damage and Repair. Dordrecht, Academic Publishers, 2004, pp 575-588.
2. Dengler R: Current treatment pathways in ALS: a European perspective. Neurology 1999;53:S4-S10.
3. Brooks BR, Miller RG, Swash M, Munsat TL: El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis. ALS 2000;1:293-299. http://www.wfnals.org/Articles/elescorial1998criteria.htm
4. Aebersold R, Mann M: Mass spectrometry-based proteomics. Nature 2003;422:198-207.
5. Carrette O, Demalte I, Scherl A, Yalkinoglu O, Corthals P, Hochstrasser DF, Sanchez J-C: A panel of cerebrospinal fluid potential biomarkers for the diagnosis of Alzheimer's disease. Proteomics 2003;3:1486-1494.
6. Ramstrom M, Ivonin I, Johansson A, Askmark H, Markides KE, Zubarev R, Hakansson P, Aquilonius SM, Bergquist J: Cerebrospinal fluid protein patterns in neurodegenerative disease revealed by liquid chromatography-Fourier transform ion cyclotron resonance mass spectrometry. Proteomics 2004;4:4010-4018.
7. Seilhean D, Takahashi J, El Hachimi KH, Fujigasaki H, Lebre AS, Biancalana V, Dürr A, Salachas F, Hogenhuis J, de Thé H, Hauw JJ, Meininger V, Brice A, Duyckaerts C: Amyotrophic lateral sclerosis with neuronal intranuclear protein inclusions. Acta Neuropathol 2004;108:81-87.
8. Selverstone Valentine J, Hart PJ: Misfolded CuZnSOD and amyotrophic lateral Sclerosis. Proc Natl Acad Sci USA 2003;100:3617-3622.
9. Von Neuhoff N, Kollewe K, Bufler J, Wurster U, Schlegelberger B, Dengler R, Proteomics and amyotrophic lateral sclerosis: Analysis of human cerebrospinal fluid to identify disease-specific peptide and protein patterns. Amyotroph Lateral Scler Other Motor Neuron Disord 2004;5(suppl 2):28.
10. Van den Bosch L, Tilkin P, Lemmens G, Robberecht W: Minocycline delays disease onset and mortality in a transgenic model of ALS. Neuroreport 2002;13:1067-1070.
11. Nguyen MD, Julien JP, Rivest S: Induction of proinflammatory molecules in mice with amyotrophic lateral sclerosis: no requirement for proapoptotic interleukin-1β in neurodegeneration. Ann Neurol 2001;50:630-639.
12. Wilms H, Sievers J, Dengler R, Bufler J, Deuschl G, Lucius R: Intrathecal synthesis of monocyte chemoattractant protein-1 in amyotrophic lateral sclerosis: further evidence for microglial activation in neurodegeneration. J Neuroimmunol 2003;144:139-142.
13. Oertle T, Schwab ME: Nogo and its paRTNers. Trends Cell Biol 2003;13:187-194.
14. Jokic N, Gonzalez de Aguilar JL, Pradat PF, Dupuis L, Echaniz-Laguna A, Muller A, Dubourg O, Seilhean D, Hauw JJ, Loeffler JP, Meininger V: Nogo expression in muscle correlates with amyotrophic lateral sclerosis severity. Ann Neurol 2005;57:553-556.
15. Lambrechts D, Storkebaum E, Morimoto M, Del-Favero J, Desmet F, Marklund SL, Wyns S, Thijs V, Andersson J, van Marion I, Al-Chalabi A, Bornes S, Musson R, Hansen V, Beckman L, Adolfsson R, Pall HS, Prats H, Vermeire S, Rutgeerts P, Katayama S, Awata T, Leigh N, Lang-Lazdunski L, Dewerchin M, Shaw C, Moons L, Vlietinck R, Morrison K.E, Robberecht W, Van Broeckhoven C, Collen D, Andersen PM, Carmeliet P: VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death. Nat Genet 2003;34:383-394.
16. Storkebaum E, Lambrechts D, Dewerchin M, Moreno-Murciano MP, Appelmans S, Oh H, Van Damme P, Rutten B, Man WY, De Mol M, Wyns S, Manka D, Vermeulen K, Van Den Bosch L, Mertens N, Schmilz C, Robberecht W, Conway EM, Collen D, Moons L, Carmeliet P: Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS. Nat Neurosci 2005;8:85-92.
17. Magistris MR, Rösler KM, Truffert A, Myers JP: Transcranial stimulation excites virtually all motor neurons supplying the target muscle. A demonstration and a method improving the study of motor evoked potentials. Brain 1998;121:437-450.
18. Rösler KM, Truffert A, Hess CW, Magistris MR: Quantification of upper motor neuron loss in amyotrophic lateral sclerosis. Clin Neurophysiol 2000;111:2208-2218.
19. Komissarow L, Rollnik JD, Bogdanova D, Krampfl K, Khabirov FA, Kossev A, Dengler R, Bufler J: Triple stimulation technique in amyotrophic lateral sclerosis. Clin Neurophysiol 2004;115:356-360.
20. Dengler R, Konstanzer A, Hesse S, Schubert M, Wolf W: Collateral nerve sprouting and twitch forces of single motor units in conditions with partial denervation in man. Neurosci Lett 1989;97:118-122.
21. Dengler R, Konstanzer A, Küther G, Wolf W, Hesse S, Struppler A: Amyotrophic lateral sclerosis: macro-EMG and twitch forces of single motor units. Muscle Nerve 1990;3:545-550.
22. Bromberg MB, Forshew DA, Nau KL, Bromberg J, Simmons Z, Fries TJ: Motor unit number estimation, isometric strength, and electromyographic measures in amyotrophic lateral sclerosis. Muscle Nerve 1993;16:1213-1219.
23. Yuen EC, Olney RK: Longitudinal study of fiber density and motor unit number estimate in patients with amyotrophic lateral sclerosis. Neurology 1997;49:573-578.
24. Wang FC, Bouquiaux O, De Pasqua V, Delwaide PJ: Changes in motor unit numbers in patients with ALS: a longitudinal study using the adapted multiple point stimulation method. Amyotroph Lateral Scler Other Motor Neuron Disord 2002;1:31-38.
25. De Carvalho M, Chio A, Dengler R, Hecht M, Weber M, Swash M: Neurophysiological measures in amyotrophic lateral sclerosis: markers of progression in clinical trials. Amyotroph Lateral Scler Other Motor Neuron Disord 2005;6:17-28.
26. Iwasaki Y, Kinoshita M, Ikeda K, Takamiya K, Shiojima T: MRI in patients with amyotrophic lateral sclerosis: correlation with clinical features. Int J Neurosci 1991;59:253-258.
27. 1- and proton-density-weighted images. J Neurol Sci 2001;186:37-44.
28. Hecht MJ, Fellner F, Fellner C, Hilz MJ, Neundorfer B, Heuss D: Hyperintense and hypointense MRI signals of the precentral gyrus and corticospinal tract in ALS: a follow-up examination including FLAIR images. J Neurol Sci 2002;199:59-65.
29. Ellis CM, Simmons A, Jones DK, Bland J, Dawson JM, Horsfield MA, Williams SC, Leigh PN: Diffusion tensor MRI assesses corticospinal tract damage in ALS. Neurology 1999;53:1051-1058.
30. Kaufmann P, Mitsumoto H: Amyotrophic lateral sclerosis: objective upper motor neuron markers. Curr Neurol Neurosci Rep 2002;2:55-60.
31. Graham JM, Papadakis N, Evans J, Widjaja E, Romanowski CA, Paley MN, Wallis L, Wilkinson ID, Shaw PJ, Griffiths PD: Diffusion tensor imaging for the assessment of upper motor neuron integrity in ALS. Neurology 2004;63:2111-2119.
32. Karlsborg M, Rosenbaum S, Wiegell M, Simonsen H, Larsson H, Werdelin L, et al: Corticospinal tract degeneration and possible pathogenesis in ALS evaluated by MR diffusion tensor imaging. Amyotroph Lateral Scler Other Motor Neuron Disord 2004;5:136-140.
33. Sach M, Winkler G, Glauche V, Liepert J, Heimbach B, Koch MA, Büchel C, Weiller C: Diffusion tensor MRI of early upper motor neuron involvement in amyotrophic lateral sclerosis. Brain 2004;127:340-350.
34. Peschel T, Kaufmann J, Bodammer N, Bufler J, Heinze HJ, Dengler R, Grosskreutz J: Diffusion tensor imaging detects upper motor neuron involvement in ALS patients. Neurology 2004;62(suppl 5):A279.
35. Ellis CM, Suckling J, Amaro E Jr, Bullmore ET, Simmons A, Williams SC, Leigh PN: Volumetric analysis reveals corticospinal tract degeneration and extramotor involvement in ALS. Neurology 2001;57:1571-1578.
36. Ashburner J, Friston KJ: Voxel-based morphometry-the methods. Neuroimage 2000;11:805-821.
37. Grosskreutz J, Fraedrich J, Kaufmann J, Bufler J, Dengler R, Heinze HJ, Peschel T: Cortical atrophy in ALS patients as detected by voxel-based morphometry. Neurology 2004; 62(suppl 5):A279-A280.