메뉴 건너뛰기




Volumn 21, Issue 2, 2006, Pages 88-100

A phase I trial of90Y-DOTA-anti-CEA chimeric T84.66 (cT84.66) radioimmunotherapy in patients with metastatic CEA-producing malignancies

Author keywords

90yttrium; Carcinoembryonic antigen; DOTA; Phase I; Radioimmunotherapy

Indexed keywords

1,4,7,10 TETRAAZACYCLODODECANE 1,4,7,10 TETRAACETIC ACID; 1,4,7,10 TETRAAZACYCLODODECANE 1,4,7,10 TETRAACETIC ACID Y 90; ANTIBODY CONJUGATE; CARCINOEMBRYONIC ANTIGEN; PENTETATE CALCIUM; PENTETATE INDIUM IN 111; PENTETIC ACID; UNCLASSIFIED DRUG; YTTRIUM 90;

EID: 33744816826     PISSN: 10849785     EISSN: None     Source Type: Journal    
DOI: 10.1089/cbr.2006.21.88     Document Type: Article
Times cited : (47)

References (59)
  • 2
    • 0028344048 scopus 로고
    • Effect of Lym-1 radioimmunoconjugate on refractory chronic lymphocytic leukemia
    • DeNardo GL, Lewis JP, DeNardo SJ, et al. Effect of Lym-1 radioimmunoconjugate on refractory chronic lymphocytic leukemia. Cancer 1994;73:1425.
    • (1994) Cancer , vol.73 , pp. 1425
    • Denardo, G.L.1    Lewis, J.P.2    Denardo, S.J.3
  • 3
    • 0028936249 scopus 로고
    • I31I-labeled anti-CD45 antibody, combined with cyclophosphamide and total body irradiation
    • I31I-labeled anti-CD45 antibody, combined with cyclophosphamide and total body irradiation. Blood 1995;85:1122.
    • (1995) Blood , vol.85 , pp. 1122
    • Matthews, D.C.1    Appelbaum, F.R.2    Eary, J.F.3
  • 4
    • 0028823422 scopus 로고
    • Treatment of non-Hodgkin's lymphoma with radiolabeled murine, chimeric, or humanized LL2, an anti-CD22 monoclonal antibody
    • Juweid M, Sharkey RM, Markowitz A, et al. Treatment of non-Hodgkin's lymphoma with radiolabeled murine, chimeric, or humanized LL2, an anti-CD22 monoclonal antibody. Cancer Res 1995;55:5899S.
    • (1995) Cancer Res , vol.55
    • Juweid, M.1    Sharkey, R.M.2    Markowitz, A.3
  • 5
    • 0027484445 scopus 로고
    • Radiolabeled antibody therapy of B-cell lymphoma with autologous bone marrow support
    • Press OW, Eary JF, Appelbaum FR, et al. Radiolabeled antibody therapy of B-cell lymphoma with autologous bone marrow support. N Engl J Med 1993;329:1219.
    • (1993) N Engl J Med , vol.329 , pp. 1219
    • Press, O.W.1    Eary, J.F.2    Appelbaum, F.R.3
  • 6
    • 0036180910 scopus 로고    scopus 로고
    • Yttrium 90 ibritumomab tiuxetan radioimmunotherapy for relapsed or refractory low-grade non-Hodgkin's lymphoma
    • Gordon LI, Witzig TE, Wiseman GA, et al. Yttrium 90 ibritumomab tiuxetan radioimmunotherapy for relapsed or refractory low-grade non-Hodgkin's lymphoma. Sem Oncol 2002;29:87.
    • (2002) Sem Oncol , vol.29 , pp. 87
    • Gordon, L.I.1    Witzig, T.E.2    Wiseman, G.A.3
  • 7
    • 0037397622 scopus 로고    scopus 로고
    • A clinical and scientific overview of tositumomab and iodine I-131 tositumomab
    • Zelenetz AD. A clinical and scientific overview of tositumomab and iodine I-131 tositumomab. Sem Oncol (Suppl) 2003;30:22.
    • (2003) Sem Oncol (Suppl) , vol.30 , pp. 22
    • Zelenetz, A.D.1
  • 8
    • 0028308598 scopus 로고
    • Treatment of metastatic prostate carcinoma with radiolabeled antibody CC49
    • Meredith RF, Bueschen AJ, Khazaeli MB, et al. Treatment of metastatic prostate carcinoma with radiolabeled antibody CC49. J Nucl Med 1994;35:1017.
    • (1994) J Nucl Med , vol.35 , pp. 1017
    • Meredith, R.F.1    Bueschen, A.J.2    Khazaeli, M.B.3
  • 9
    • 0029779766 scopus 로고    scopus 로고
    • Radioimmunotherapy of patients with small-volume tumors using iodine-131-labeled anti-CEA monoclonal antibody NP-4 F(ab')2
    • Juweid ME, Sharkey RM, Behr T, et al. Radioimmunotherapy of patients with small-volume tumors using iodine-131-labeled anti-CEA monoclonal antibody NP-4 F(ab')2. J Nucl Med 1996;37:1504.
    • (1996) J Nucl Med , vol.37 , pp. 1504
    • Juweid, M.E.1    Sharkey, R.M.2    Behr, T.3
  • 10
    • 0030901830 scopus 로고    scopus 로고
    • Radioimmunotherapy for advanced breast cancer using I-131-ChL6 antibody
    • DeNardo SJ, O'Grady LF, Richman CM, et al. Radioimmunotherapy for advanced breast cancer using I-131-ChL6 antibody. Anticancer Res 1997;17:1745.
    • (1997) Anticancer Res , vol.17 , pp. 1745
    • Denardo, S.J.1    O'Grady, L.F.2    Richman, C.M.3
  • 11
    • 0033941892 scopus 로고    scopus 로고
    • 131I-labeled chimeric monoclonal antibody MOv18 in patients with ovarian cancer
    • 131I-labeled chimeric monoclonal antibody MOv18 in patients with ovarian cancer. J Nucl Med 2000;41:1168.
    • (2000) J Nucl Med , vol.41 , pp. 1168
    • Van Zanten-Przybysz, I.1    Molthoff, C.2    Roos, J.C.3
  • 12
    • 0026634188 scopus 로고
    • Clinical experience with rhenium-186-labeled monoclonal antibodies for radioimmunotherapy results of phase I trials
    • Breitz HB, Weiden PL, Vanderheyden J-L, et al. Clinical experience with rhenium-186-labeled monoclonal antibodies for radioimmunotherapy results of phase I trials. J Nucl Med 1992;33:1099.
    • (1992) J Nucl Med , vol.33 , pp. 1099
    • Breitz, H.B.1    Weiden, P.L.2    Vanderheyden, J.-L.3
  • 14
    • 0347995052 scopus 로고    scopus 로고
    • A phase I trial of Y-90-anti-carcinoembryonic antigen chimeric T84.66 radioimmunotherapy with 5-fluorouracil in patients with metastatic colorectal cancer
    • Wong JYC, Shibata S, Williams LE, et al. A phase I trial of Y-90-anti-carcinoembryonic antigen chimeric T84.66 radioimmunotherapy with 5-fluorouracil in patients with metastatic colorectal cancer. Clin Cancer Res 2003;9:5842.
    • (2003) Clin Cancer Res , vol.9 , pp. 5842
    • Wong, J.Y.C.1    Shibata, S.2    Williams, L.E.3
  • 15
    • 0030816178 scopus 로고    scopus 로고
    • Radioimmunotherapy for breast cancer using indium-111/yttrium-90 BrE-3: Results of a phase I clinical trial
    • De Nardo SJ, Kramer EL, O'Donnell RT, et al. Radioimmunotherapy for breast cancer using indium-111/yttrium-90 BrE-3: Results of a phase I clinical trial. J Nucl Med 1997;38:1180.
    • (1997) J Nucl Med , vol.38 , pp. 1180
    • De Nardo, S.J.1    Kramer, E.L.2    O'Donnell, R.T.3
  • 16
    • 0030901830 scopus 로고    scopus 로고
    • Radioimmunotherapy for advanced breast cancer using I-131-ChL6 antibody
    • DeNardo SJ, O'Grady LF, Richman CM, et al. Radioimmunotherapy for advanced breast cancer using I-131-ChL6 antibody. Anticancer Res 1997;17:1745.
    • (1997) Anticancer Res , vol.17 , pp. 1745
    • Denardo, S.J.1    O'Grady, L.F.2    Richman, C.M.3
  • 17
    • 0026634188 scopus 로고
    • Clinical experience with rhenium-186-labeled monoclonal antibodies for radioimmunotherapy: Results of phase I trials
    • Breitz HB, Weiden PL, Vanderheyden JL, et al. Clinical experience with rhenium-186-labeled monoclonal antibodies for radioimmunotherapy: Results of phase I trials. J Nucl Med 1992;33:1099.
    • (1992) J Nucl Med , vol.33 , pp. 1099
    • Breitz, H.B.1    Weiden, P.L.2    Vanderheyden, J.L.3
  • 18
    • 0346815110 scopus 로고    scopus 로고
    • Radioimmunotherapy of head and neck cancer with 186-re-labeled humanized moncolonal antibody bivatuzumab. A dosimetric analysis
    • 158P
    • Postema EJ, Borjesson PK, Buijs WC, et al. Radioimmunotherapy of head and neck cancer with 186-re-labeled humanized moncolonal antibody bivatuzumab. A dosimetric analysis. [abstract] J Nucl Med 2002;43:158P.
    • (2002) J Nucl Med , vol.43
    • Postema, E.J.1    Borjesson, P.K.2    Buijs, W.C.3
  • 19
    • 0030816178 scopus 로고    scopus 로고
    • Radioimmunotherapy for breast cancer using indium-111/yttrium-90 BrE-3: Results of a phase I clinical trial
    • DeNardo SJ, Kramer EL, O'Donnell RT, et al. Radioimmunotherapy for breast cancer using indium-111/yttrium-90 BrE-3: Results of a phase I clinical trial. J Nucl Med 1997;38:1180.
    • (1997) J Nucl Med , vol.38 , pp. 1180
    • Denardo, S.J.1    Kramer, E.L.2    O'Donnell, R.T.3
  • 20
    • 0033755115 scopus 로고    scopus 로고
    • Phase I radioimmunotherapy trials evaluating Y-90-labeled anti-CEA chimeric T84.66 in patients with metastatic CEA-producing malignancies
    • Wong JYC, Chu DZ, Yamauchi DM, et al. Phase I radioimmunotherapy trials evaluating Y-90-labeled anti-CEA chimeric T84.66 in patients with metastatic CEA-producing malignancies. Clin Cancer Res 2000;6:3855.
    • (2000) Clin Cancer Res , vol.6 , pp. 3855
    • Wong, J.Y.C.1    Chu, D.Z.2    Yamauchi, D.M.3
  • 21
    • 0027935133 scopus 로고
    • 131I-labeled monoclonal antibody A33 in patients with advanced colon cancer
    • 131I-labeled monoclonal antibody A33 in patients with advanced colon cancer. J Clin Oncol 1994;12:1561.
    • (1994) J Clin Oncol , vol.12 , pp. 1561
    • Welt, S.1    Divgi, C.R.2    Kemeny, N.3
  • 22
    • 0028947670 scopus 로고
    • Phase I radioimmunotherapy trial with iodine-131-CC49 in metastatic colon carcinoma
    • Divgi CR, Scott AM, Dantis L, et al. Phase I radioimmunotherapy trial with iodine-131-CC49 in metastatic colon carcinoma. J Nucl Med 1995;36:586.
    • (1995) J Nucl Med , vol.36 , pp. 586
    • Divgi, C.R.1    Scott, A.M.2    Dantis, L.3
  • 23
    • 0024503756 scopus 로고
    • Intraperitoneal radioimmunotherapy for ovarian cancer: Pharmacokinetics, toxicity, and efficacy of 1-131 labeled monoclonal antibodies
    • Stewart JS, Hird V, Snook D, et al. Intraperitoneal radioimmunotherapy for ovarian cancer: Pharmacokinetics, toxicity, and efficacy of 1-131 labeled monoclonal antibodies. Int J Radiat Oncol Biol Phys 1989;16:405.
    • (1989) Int J Radiat Oncol Biol Phys , vol.16 , pp. 405
    • Stewart, J.S.1    Hird, V.2    Snook, D.3
  • 24
    • 0027292537 scopus 로고
    • A phase I trial of a rhenium 186-labeled monoclonal antibody administered intraperitoneally in ovarian carcinoma: Toxicity and clinical response
    • Jacobs AJ, Fer M, Su FM, et al. A phase I trial of a rhenium 186-labeled monoclonal antibody administered intraperitoneally in ovarian carcinoma: Toxicity and clinical response. Obstet Gynecol 1993;82:586.
    • (1993) Obstet Gynecol , vol.82 , pp. 586
    • Jacobs, A.J.1    Fer, M.2    Su, F.M.3
  • 25
    • 0025237122 scopus 로고
    • Yttrium-90-labeled monoclonal antibody for therapy: Labeling by a new macrocyclic bifunctional chelating agent
    • Deshpande SV, DeNardo SJ, Kukis DL, et al. Yttrium-90-labeled monoclonal antibody for therapy: Labeling by a new macrocyclic bifunctional chelating agent. J Nucl Med 1990;31:473.
    • (1990) J Nucl Med , vol.31 , pp. 473
    • Deshpande, S.V.1    Denardo, S.J.2    Kukis, D.L.3
  • 26
    • 0034794794 scopus 로고    scopus 로고
    • Intraperitoneal radioimmunochemotherapy of ovarian cancer: A phase I study
    • Meredith RF, Alvarez RD, Partridge EE, et al. Intraperitoneal radioimmunochemotherapy of ovarian cancer: A phase I study. Cancer Biother Radiopharm 2001;16:305.
    • (2001) Cancer Biother Radiopharm , vol.16 , pp. 305
    • Meredith, R.F.1    Alvarez, R.D.2    Partridge, E.E.3
  • 27
    • 0036715292 scopus 로고    scopus 로고
    • 90yttrium-CC49 intraperitoneal radioimmunotherapy for ovarian cancer
    • 90yttrium-CC49 intraperitoneal radioimmunotherapy for ovarian cancer. Clin Cancer Res 2002;8:2806.
    • (2002) Clin Cancer Res , vol.8 , pp. 2806
    • Alvaraz, R.D.1    Huh, W.K.2    Khazaeli, M.B.3
  • 28
    • 23844507146 scopus 로고    scopus 로고
    • High-dose radioimmunotherapy combined with fixed, low-dose paclitaxel in metastatic prostate and breast cancer by using a MUC-1 monoclonal antibody, m170, linked to indium 111/yttrium-90 via a cathepsin cleavable linker with cyclosporine to prevent human anti-mouse antibody
    • Richman CM, DeNardo SJ, O'Donnell RT, et al. High-dose radioimmunotherapy combined with fixed, low-dose paclitaxel in metastatic prostate and breast cancer by using a MUC-1 monoclonal antibody, m170, linked to indium 111/yttrium-90 via a cathepsin cleavable linker with cyclosporine to prevent human anti-mouse antibody. Clin Cancer Res 2005;11:5920.
    • (2005) Clin Cancer Res , vol.11 , pp. 5920
    • Richman, C.M.1    Denardo, S.J.2    O'Donnell, R.T.3
  • 29
    • 0025360623 scopus 로고
    • Macrocyclic chelates of radiometals for diagnosis and therapy
    • Meares CF, Moi MK, Diril H, et al. Macrocyclic chelates of radiometals for diagnosis and therapy. Br J Cancer 1990;10:21.
    • (1990) Br J Cancer , vol.10 , pp. 21
    • Meares, C.F.1    Moi, M.K.2    Diril, H.3
  • 30
    • 0029053874 scopus 로고
    • Pharmacokinetics of chimeric L6 conjugated to indium-111- And yttrium-90-DOTA-peptide in tumor-bearing mice
    • DeNardo SJ, Zhong GR, Salako Q, et al. Pharmacokinetics of chimeric L6 conjugated to indium-111- and yttrium-90-DOTA-peptide in tumor-bearing mice. J Nucl Med 1995;36:829.
    • (1995) J Nucl Med , vol.36 , pp. 829
    • Denardo, S.J.1    Zhong, G.R.2    Salako, Q.3
  • 32
    • 0037207880 scopus 로고    scopus 로고
    • 90Y-DOTA-hLL2: An agent for radioimmunotherapy of non-Hodgkins' lymphoma
    • Griffiths GL, Govindan SV, Sharkey RM, et al. 90Y-DOTA-hLL2: An agent for radioimmunotherapy of non-Hodgkins' lymphoma. J Nucl Med 2003;44:77.
    • (2003) J Nucl Med , vol.44 , pp. 77
    • Griffiths, G.L.1    Govindan, S.V.2    Sharkey, R.M.3
  • 33
    • 0028285302 scopus 로고
    • Comparative biodistribution of indium- And yttrium-labeled B3 monoclonal antibody conjugated to either 2-(p-SCN-Bz)-6-methyl-DTPA (1B4M-DTPA) or 2-(p-SCN-Bz)-1,4,7,10-tetra-azacyclododecane tetra-acetic acid (2B-DOTA)
    • Camera L, Kinuya S, Garmestani K, et al. Comparative biodistribution of indium- and yttrium-labeled B3 monoclonal antibody conjugated to either 2-(p-SCN-Bz)-6-methyl-DTPA (1B4M-DTPA) or 2-(p-SCN-Bz)-1,4,7,10-tetra- azacyclododecane tetra-acetic acid (2B-DOTA). Eur J Nucl Med 1994;21:640.
    • (1994) Eur J Nucl Med , vol.21 , pp. 640
    • Camera, L.1    Kinuya, S.2    Garmestani, K.3
  • 34
    • 0027958499 scopus 로고
    • Comparative toxicity studies of yttrium-90 MX-DTPA and 2-IT-BAD conjugated monoclonal antibody (BrE-3)
    • DeNardo GL, Kroger LA, DeNardo SJ, et al. Comparative toxicity studies of yttrium-90 MX-DTPA and 2-IT-BAD conjugated monoclonal antibody (BrE-3). Cancer 1994;73:1012.
    • (1994) Cancer , vol.73 , pp. 1012
    • Denardo, G.L.1    Kroger, L.A.2    Denardo, S.J.3
  • 40
    • 0036074251 scopus 로고    scopus 로고
    • 1-octreotate: A somatostatin analog for labeling with metal and halogen radionuclides for cancer imaging and therapy
    • 1-octreotate: A somatostatin analog for labeling with metal and halogen radionuclides for cancer imaging and therapy. Bioconjug Chem 2002;13:721.
    • (2002) Bioconjug Chem , vol.13 , pp. 721
    • Li, W.P.1    Lewis, J.S.2    Kim, J.3
  • 41
    • 0028892312 scopus 로고
    • 90yttrium radiolabeled anti-CEA chimeric T84.66 in a phase I radioimmunotherapy trial
    • 90yttrium radiolabeled anti-CEA chimeric T84.66 in a phase I radioimmunotherapy trial. Cancer Res 1995;55:5929S.
    • (1995) Cancer Res , vol.55
    • Wong, J.Y.C.1    Williams, L.E.2    Yamauchi, D.M.3
  • 42
    • 0009464272 scopus 로고    scopus 로고
    • 90Y)-chimeric T84.66 (cT84.66) anti-CEA antibody and autologous stem cell support in CEA-producing metastatic breast cancer
    • 90Y)-chimeric T84.66 (cT84.66) anti-CEA antibody and autologous stem cell support in CEA-producing metastatic breast cancer. Proc Am Assoc Cancer Res 1998;39:380.
    • (1998) Proc Am Assoc Cancer Res , vol.39 , pp. 380
    • Wong, J.Y.C.1    Somlo, G.2    Odom-Maryon, T.3
  • 43
    • 0002370108 scopus 로고    scopus 로고
    • Measuring antibody affinity using biosensors
    • Chiswell D, Mac-Cafferty J, Moogenboom H, eds. London: Oxford Press
    • Hefta LJ, Wu AM, Neaumaier M, et al. Measuring antibody affinity using biosensors. In: Chiswell D, Mac-Cafferty J, Moogenboom H, eds. Antibody Engineering: A Practical Approach. London: Oxford Press, 1996:99.
    • (1996) Antibody Engineering: A Practical Approach , pp. 99
    • Hefta, L.J.1    Wu, A.M.2    Neaumaier, M.3
  • 44
    • 0025232417 scopus 로고
    • Cloning of the genes for T84.66, an antibody that has a high specificity and affinity for carcinoembryonic antigen, and expression of chimeric human/mouse T84.66 genes in myeloma and Chinese hamster ovary cells
    • Neumaier M, Shively L, Chen FS, et al. Cloning of the genes for T84.66, an antibody that has a high specificity and affinity for carcinoembryonic antigen, and expression of chimeric human/mouse T84.66 genes in myeloma and Chinese hamster ovary cells. Cancer Res 1990;50:2128.
    • (1990) Cancer Res , vol.50 , pp. 2128
    • Neumaier, M.1    Shively, L.2    Chen, F.S.3
  • 45
    • 0031473623 scopus 로고    scopus 로고
    • Clinical evaluation of indium-111 -labeled chimeric anti-CEA monoclonal antibody
    • Wong JY, Thomas GE, Yamauchi D, et al. Clinical evaluation of indium-111 -labeled chimeric anti-CEA monoclonal antibody. J Nucl Med 1997;38:1951.
    • (1997) J Nucl Med , vol.38 , pp. 1951
    • Wong, J.Y.1    Thomas, G.E.2    Yamauchi, D.3
  • 46
    • 0035083298 scopus 로고    scopus 로고
    • An improved method for conjugating monoclonal antibodies with N-hydroxysulfosuccinimidyl DOTA
    • Lewis MR, Kao JY, Anderson A-L, et al. An improved method for conjugating monoclonal antibodies with N-hydroxysulfosuccinimidyl DOTA. Bioconjug Chem 2001;12:320.
    • (2001) Bioconjug Chem , vol.12 , pp. 320
    • Lewis, M.R.1    Kao, J.Y.2    Anderson, A.-L.3
  • 47
    • 0032438053 scopus 로고    scopus 로고
    • Dose escalation trial of indium-111-labeled anti-carcinoembryonic antigen chimeric monoclonal antibody (chimeric T84.66) in presurgical colorectal cancer patients
    • Wong JY, Chu DZ, Yamauchi D, et al. Dose escalation trial of indium-111-labeled anti-carcinoembryonic antigen chimeric monoclonal antibody (chimeric T84.66) in presurgical colorectal cancer patients. J Nucl Med 1998;39:2097.
    • (1998) J Nucl Med , vol.39 , pp. 2097
    • Wong, J.Y.1    Chu, D.Z.2    Yamauchi, D.3
  • 48
    • 0031459604 scopus 로고    scopus 로고
    • Pharmacokinetics modeling and absorbed dose estimation for a chimeric anti-CEA antibody (cT84.66) in humans
    • Odom-Maryon TL, Williams LE, Chai A, et al. Pharmacokinetics modeling and absorbed dose estimation for a chimeric anti-CEA antibody (cT84.66) in humans. J Nucl Med 1997;38:1959.
    • (1997) J Nucl Med , vol.38 , pp. 1959
    • Odom-Maryon, T.L.1    Williams, L.E.2    Chai, A.3
  • 49
    • 0038720544 scopus 로고
    • MIRD Pamphlet No.1. A schema for absorbed-dose calculations for biologically distributed radionuclides
    • Loevinger R, Berman M. MIRD Pamphlet No.1. A schema for absorbed-dose calculations for biologically distributed radionuclides. J Nucl Med 1968;9(Suppl 1):7.
    • (1968) J Nucl Med , vol.9 , Issue.SUPPL. 1 , pp. 7
    • Loevinger, R.1    Berman, M.2
  • 50
    • 0030002992 scopus 로고    scopus 로고
    • MIRDOSE: Personal computer software for internal dose assessment in nuclear medicine
    • Stabin MG. MIRDOSE: Personal computer software for internal dose assessment in nuclear medicine. J Nucl Med 1996;37:538.
    • (1996) J Nucl Med , vol.37 , pp. 538
    • Stabin, M.G.1
  • 52
    • 0017098356 scopus 로고
    • In vivo queantitation of lesion radioactivity using external counting methods
    • Thomas SR, Maxon HR, Kereiakes JG. In vivo queantitation of lesion radioactivity using external counting methods. Med Physics 1976;3:253.
    • (1976) Med Physics , vol.3 , pp. 253
    • Thomas, S.R.1    Maxon, H.R.2    Kereiakes, J.G.3
  • 55
    • 0028535424 scopus 로고
    • A facile, water-soluble method for modification of proteins with DOTA. Use of elevated temperature and optimized pH to achieve high specific activity and high chelate stability in radiolabeled immunoconjugates
    • Lewis MR, Raubitschek A, Shively JE. A facile, water-soluble method for modification of proteins with DOTA. Use of elevated temperature and optimized pH to achieve high specific activity and high chelate stability in radiolabeled immunoconjugates. Bioconjug Chem 1994;5:565.
    • (1994) Bioconjug Chem , vol.5 , pp. 565
    • Lewis, M.R.1    Raubitschek, A.2    Shively, J.E.3
  • 57
    • 0033982673 scopus 로고    scopus 로고
    • Evalauting changes in stable chromosomal translocation frequency in patients receiving radioimmunotherapy
    • Wong JYC, Wang J, Liu A, et al. Evalauting changes in stable chromosomal translocation frequency in patients receiving radioimmunotherapy. Int J Radiat Oncol Biol Phys 2000;3:599.
    • (2000) Int J Radiat Oncol Biol Phys , vol.3 , pp. 599
    • Wong, J.Y.C.1    Wang, J.2    Liu, A.3
  • 58
    • 0026582152 scopus 로고
    • Development of humoral immune responses against a macrocyclic chelating agent (DOTA) in cancer patients receiving radioimmunoconjugates for imaging and therapy
    • Kosmas C, Snook D, Gooden CS, et al. Development of humoral immune responses against a macrocyclic chelating agent (DOTA) in cancer patients receiving radioimmunoconjugates for imaging and therapy. Cancer Res 1992;52:904.
    • (1992) Cancer Res , vol.52 , pp. 904
    • Kosmas, C.1    Snook, D.2    Gooden, C.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.