Intrapartum Asphyxia and Cerebral Palsy: Is There a Link?

Clinics in Perinatology

Volumn 33, Issue 2, 2006, Pages 335-353

  Perlman, Jeffrey M ^a  

^a WEILL CORNELL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTIVE BEHAVIOR; AMNION FLUID ANALYSIS; APGAR SCORE; BRAIN DAMAGE; BRAIN DISEASE; BRAIN INJURY; BRAIN PERFUSION; BRAIN SCINTISCANNING; CARDIOVASCULAR RESPONSE; CENTRAL NERVOUS SYSTEM DISEASE; CEREBRAL PALSY; DELIVERY ROOM; DISEASE MARKER; ENCEPHALOMALACIA; EXTRAPYRAMIDAL SYNDROME; FETUS ELECTROCARDIOGRAPHY; HUMAN; HYPOXIA; ISCHEMIA; LABOR; MECONIUM; MULTIPLE ORGAN FAILURE; NERVE CELL NECROSIS; NEUROLOGIC DISEASE; NEUROPATHOLOGY; OXYGEN CONSUMPTION; PATHOGENESIS; PERINATAL ASPHYXIA; PLACENTA CIRCULATION; PRIORITY JOURNAL; RESUSCITATION; REVIEW; RISK FACTOR;

APGAR SCORE; CARDIOPULMONARY RESUSCITATION; CEREBRAL PALSY; FEMALE; FETAL MONITORING; HUMANS; HYPOXIA-ISCHEMIA, BRAIN; INFANT, NEWBORN; PREGNANCY; RISK FACTORS;

EID: 33744806908     PISSN: 00955108     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clp.2006.03.004     Document Type: Review

References (94)

1. Volpe J.J. Neurology of the newborn. 4th edition (2001), WB Saunders Company, Philadelphia
2. Paneth N., Damiano D., Rosenbaum P., et al. The classification of cerebral palsy. Dev Med Child Neuro 46 (2005) 571-576
3. American College of Obstetricians and Gynecologists. Task Force on Neonatal Encephalopathy and Cerebral. Neonatal encephalopathy and cerebral palsy (2003), American College of Obstetricians and Gynecologists, Washington, DC
4. Nelson K.B. The epidemiology of cerebral palsy in term infants. Ment Retard Dev Disabil Res Rev 8 (2002) 146-150
5. Blair E., and Stanley F.J. Intrapartum asphyxia-a rare cause of cerebral palsy. J Pediatr 112 (1988) 515-519
6. Torfs C.P., Van der berg B.J., and Oeschali F.W. Prenatal and perinatal factors in the etiology of cerebral palsy. J Pediatr 116 (1990) 615-619
7. Gluckman P.D., Wyatt J.S., Azzopardi D., et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomized trial. Lancet 365 (2005) 663-670
8. Shankaran S., Laptook A.R., Ehrenkrantz R.A., et al. Whole body hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med 353 (2005) 1574-1584
9. Low J.A., Panagiotopoulos C., and Derrick E.J. Newborn complications after intrapartum asphyxia with metabolic acidosis in the preterm fetus. Am J Obstet Gynecol 172 (1995) 805-809
10. Freeman J.M., and Nelson K.B. Intrapartum asphyxia and cerebral palsy. Pediatrics 82 (1988) 240-249
11. Towell M.E. The rationale for biochemical monitoring of the fetus. J Perinat Med 16 Suppl 1 (1988) 55-70
12. Goldaber K.G., Gilstrap L.C., Leveno K.J., et al. Pathologic fetal acidemia. Obstet Gynecol 78 (1991) 1103-1107
13. Sehdev H.M., Stamilio D.M., Macones G.A., et al. Predictive factors for neonatal morbidity in neonates with an umbilical arterial cord pH less than 7.00. Am J Obstet Gynecol 177 (1997) 1030-1034
14. King T., Jackson G., Burks M., et al. Unanticipated severe umbilical artery acidemia in term infants admitted to a newborn nursery: is it benign?. J Pediatr 132 (1998) 624-629
15. Fee S.C., Malee K., Deddish R., et al. Severe acidosis and subsequent neurologic status. Am J Obstet Gynecol 162 (1990) 802-806
16. Goodwin T.M., Belai I., Hernandez P., et al. Asphyxial complications in the term newborn with severe umbilical acidemia. Am J Obstet Gynecol 162 (1992) 1506-1512
17. Perlman J.M., and Risser R. Severe fetal acidemia: neonatal neurological features and short term outcome. Pediatr Neurol 9 (1992) 277-282
18. Lassen N.A., and Christensen M.S. Physiology of cerebral blood flow. Br J Anaesth 48 (1976) 719-734
19. Behrman R.E., Lees M.H., Petersen E.N., et al. Distribution of circulation in the normal and asphyxiated fetal primate. Am J Obstet Gynecol 108 (1970) 956-969
20. Cohn E.H., Sacks E.J., Heyman M.A., et al. Cardiovascular responses to hypoxemia and acidemia in fetal lambs. Am J Obstet Gynecol 120 (1974) 817-824
21. Peeters L., Sheldon R., Jones M., et al. Blood flow to fetal organs as a function of arterial oxygen content. Am J Obstet Gynecol 135 (1979) 637-646
22. Vannucci R.C., and Duffy T.E. Cerebral metabolism in newborn dogs during reversible asphyxia. Am Neurol 1 (1977) 528-534
23. Dawes G. Foetal and neonatal physiology (1968), Year Book Medical Publishers, Inc., Chicago
24. Jones Jr. M.D., Sheldon R.E., Peeters L.L., et al. Regulation of cerebral blood flow in the ovine fetus. Am J Physiol 235 (1978) H162-H166
25. Koehler R.C., Jones Jr. M.D., and Traystman R.J. Cerebral circulation response to carbon monoxide and hypoxic hypoxia in the lamb. Am J Physiol 243 (1982) H27-H32
26. Ashwal S., Dale P.S., and Longo I.D. Regional cerebral blood flow: studies in the fetal lamb during hypoxia, hypercapnia, acidosis and hypotension. Pediatr Res 18 (1984) 1309-1316
27. Johnson E.W., Palahniwk R.J., Tween W.A., et al. Regional cerebral blood flow changes during severe fetal asphyxia produced by slow partial umbilical cord compression. Am J Obstet Gynecol 135 (1979) 48-52
28. Powers W.J., Grubb Jr. R.L., Darriet D., et al. Cerebral blood flow and cerebral metabolic rates of oxygen requirements for cerebral function and viability in humans. J Cereb Blood Flow Metab 5 (1985) 600-608
29. Heiss W.D., and Rosner G. Functional recovery of cortical neurons as related to the degree and duration of ischemia. Ann Neurol 14 (1983) 294-301
30. + at critical levels of brain ischemia. Stroke 8 (1977) 51-57
31. Altman D.I., Powers W.I., Perlman J.M., et al. Cerebral blood flow requirement for brain viability in newborn infants is lower than in adults. Ann Neurol 24 (1988) 218-226
32. Duffy T.E., Kohle S.J., and Vannucci R.C. Carbohydrate and energy metabolism in perinatal rat brain: relation to survival in anoxia. J Neurochem 24 (1975) 271-276
33. Holowach-Thurston J., and McDougal Jr. D.B. Effects of ischemia on metabolism of the brain of the newborn mouse. Am J Physiol 216 (1964) 348-352
34. Yager J., Heitjan D.F., Towfighi J., et al. Effect of insulin-induced and fasting hypoglycemia on perinatal hypoxic ischemic brain damage. Pediatr Res 31 (1992) 138-142
35. Cremer J.E. Substrate utilization and brain development. J Cereb Blood Flow Metab 2 (1982) 394-407
36. Dawes G.S., Mott J.C., and Shelley H.J. The importance of cardiac glycogen for the maintenance of life in foetal lambs and newborn animals during anoxia. J Physiol 146 (1959) 519-538
37. Wells R.J., Friedman W.F., and Sobel B.E. Increased oxidative metabolism in the fetal and neonatal lamb heart. Am J Physiol 222 (1972) 1488-1493
38. Wimberley P.D. A review of oxygen and delivery in the neonate. Scand J Clin Lab Invest 160 Suppl (1982) 114-118
39. Ferreiro D.M. Protecting neurons. Epilepsia 46 Suppl 7 (2005) 45-51
40. Myers R.E. Four patterns of perinatal brain damage and their conditions of occurrence in the primate. Adv Neurology 10 (1975) 223-234
41. Pasternak J.F., and Gorey M.T. The syndrome of near total asphyxia in the term infant. Pediatr Neurol 18 (1998) 391-398
42. Wu Y.W., and Colford J.M. Chorioamnionitis as a risk factor for cerebral palsy. JAMA 284 (2000) 1417-1424
43. Shalak L., Laptook A., Ramilo O., et al. Clinical chorioamnionitis, elevated cytokines and brain injury in term infants. Pediatrics 110 (2002) 673-680
44. Kraus F.T., and Acheen V.I. Fetal thrombotic vasculopathy in the placenta: cerebral thrombi and infarcts, coagulopathies and cerebral palsy. Hum Pathol 30 (1999) 759-769
45. Quilligan E.J., and Paul R.H. Fetal monitoring: is it worth it. Obstet Gynecol 45 (1975) 96-110
46. Grant A., O'Brien N., Marie-Theriese J., et al. Cerebral palsy among children born during the Dublin randomized trial of intrapartum monitoring. Lancet 111 (1989) 1233-1236
47. Painter M.J., Scott M., Hirsch R.P., et al. Fetal heart rate patterns during labor: neurologic and cognitive development at six to nine years of age. Am J Obstet Gynecol 159 (1988) 854-858
48. Nelson K.B., and Ellenberg J.H. Obstetric complications as risk factors for cerebral palsy or seizure disorders. JAMA 251 (1984) 1843-1848
49. Gregory G.A., Gooding C.A., Phibbs R.H., et al. Meconium aspiration in infants-a prospective study. J Pediatr 85 (1974) 848-852
50. Miller F.C., and Sacks D.A. Significance of meconium during labor. Am J Obstet Gynecol 122 (1975) 573-580
51. Meis P.J., Hall III M., Marshall J.R., et al. Meconium passage. A new classification for risk assessment during labor. Am J Obstet Gynecol 131 (1978) 509-513
52. Abramovici H., Brandes J.M., Fuchs K., et al. Meconium during delivery: a sign of compensated fetal distress. Am J Obstet Gynecol 118 (1974) 251-254
53. Yeomans E.R., Gilstrap L.C., Leveno K.J., et al. Meconium in the amniotic fluid and fetal acid-base status. Obstet Gynecol 73 (1989) 175-178
54. American Academy of Pediatrics, and American College of Obstetrics and Gynecologists. Use and abuse of the Apgar score. ACOG Committee Opinion 174 (1996), AAP, Elk Grove Village (IL)
55. Nelson K.B., and Ellenberg J.H. Apgar score as predictors of chronic neurologic disability. Pediatrics 68 (1981) 36-44
56. Casey B.M., McIntire D.D., and Leveno K.J. The continuing value of the Apgar score for the assessment of newborn infants. N Engl J Med 344 (2001) 467-471
57. Moster D., Lie R.T., Irgens L.M., et al. The association of Apgar score with subsequent death and cerebral palsy in term infants. J Pediatr 138 (2001) 798-803
58. Perlman J.M., and Risser R. Cardiopulmonary resuscitation in the delivery room: associated clinical events. Arch Pediatr Adolesc Med 149 (1995) 20-25
59. Perlman J.M., and Risser R. Can infants with neonatal seizures secondary to perinatal asphyxia be rapidly identified by current high risk markers. Pediatrics 97 (1996) 456
60. DeReuck J. The human periventricular arterial blood supply and the anatomy of cerebral infarctions. Eur Neurol 5 (1973) 321-334
61. Roland E.H., Hill A., Rodriguez E., et al. Perinatal hypoxia-ischemic thalamic injury: clinical features and neuroimaging. Ann Neurol 44 (1998) 161-166
62. Takashima S., and Tanaka K. Development of cerebrovascular architecture and its relationship to periventricular leukomalacia. Arch Neurol 35 (1978) 11-16
63. Perlman J.M., Risser R., and Broyles R.S. Bilateral cystic periventricular leukomalacia in the premature infant: associated risk factors. Pediatrics 97 (1996) 822-826
64. Rogers B., Msall M., Owens T., et al. Cystic periventricular leukomalacia and type of cerebral palsy in preterm infants. J Pediatr 125 (1994) S1-S8
65. Myers R.E. Cerebral ischemia in the developing primate fetus. Biomed Biochim Acta 48 (1989) S137-S142
66. Perlman J.M., Rollins N.K., and Evans D. Neonatal stroke: clinical characteristics and cerebral blood flow velocity measurements. Pediatr Neurol 11 (1994) 281-284
67. Perlman J.M. Brain injury in the term infant. Semin Perinatol 28 (2004) 415-424
68. Sarnat H.B., and Sarnat M.S. Neonatal encephalopathy following fetal distress. A clinical and electroencephalographic study. Arch Neurol 33 (1976) 696-705
69. Nelson K.B., and Levinton A. How much of neonatal encephalopathy is due to birth asphyxia?. Am J Dis Child 315 (1991) 81-86
70. Dauber I.M., Krauss A.N., Symchych P.S., et al. Renal failure following perinatal anoxia. J Pediatr 88 (1976) 851-855
71. Begwin F., Dunnihood D.B., and Quilligan E.J. Effect of carbon dioxide elevation on renal blood flow in the fetal lamb in utero. Am J Obstet Gynecol 199 (1974) 630-635
72. 2 microglobulin in full term infants: evidence for proximal tubular dysfunction in term infants with meconium stained amniotic fluid. Pediatrics 76 (1985) 958-963
73. Stork H., and Geiger R. Renal tubular dysfunction following vascular accidents of the kidneys in the newborn period. J Pediatr 83 (1973) 933-937
74. Korst L.M., Phelan J.P., Ahn M.O., et al. Nucleated red blood cells: an update on the marker for fetal asphyxia. Am J Obstet Gynecol 175 (1996) 843-846
75. Phelan J.P., Korst L.M., Ahn M.O., et al. Neonatal nucleated red blood cell and lymphocyte counts in fetal brain injury. Obstet Gynecol 91 (1998) 485-489
76. Perlman J.M., Tack E.C., Martin T., et al. Acute systemic organ injury in term infants after asphyxia. Am J Dis Child 143 (1989) 617-620
77. Martinancel A., Garcia-Alix A., Gaya F., et al. Multiple organ involvement in perinatal asphyxia. J Pediatr 127 (1995) 786-793
78. Perlman J.M., and Tack E.C. Renal injury in the asphyxiated newborn infant: relationship to neurological outcome. J Pediatr 113 (1998) 875-879
79. Phelan J.P., Nelson K.B., Ellenberg J.H., et al. Intrapartum fetal asphyxial brain injury with absent multiorgan system dysfunction. J Matern Fetal Med 7 (1998) 19-22
80. Barkovich A.J. The encephalopathic neonate: choosing the proper imaging technique. AJNR Am J Neuroradiol 18 (1997) 1816-1820
81. Barkovich A.J., Westmark K., Partridge C., et al. Perinatal asphyxia: MR-findings in the first 10 days. AJNR Am J Neuroradiol 16 (1995) 427-438
82. Mercuri E., Guzzetta A., Haataja L., et al. Neonatal neurological examination in infants with hypoxic ischemic encephalopathy: correlation with MRI findings. Neuropediatrics 30 (1999) 83-89
83. Robertson R., Ben Sira L., Barnes P., et al. MR line-scan diffusion-weighted imaging of term neonates with perinatal brain ischemia AJNR. AJNR Am J Neuroradiol 20 (1999) 1658-1670
84. Saul J.S., Robertson R.L., Tzika A.A., et al. Time course of changes in diffusion-weighted magnetic resonance imaging in a case of neonatal encephalopathy with defined onset and duration of hypoxic-ischemic insult. Pediatrics 35 2 (2001) 148-151
85. Rutherford M., Counsell S., Allsop J., et al. Diffusion-weighted magnetic resonance imaging in term perinatal brain injury. A comparison with site of lesion and time from birth. Pediatrics 144 (2004) 1004-1014
86. Perlman J.M. Intrapartum hypoxic-ischemic cerebral injury and subsequent cerebral palsy: medicolegal issues. Pediatrics 99 (1997) 851-859
87. Badawi N., Watson L., Petterson B., et al. What constitutes cerebral palsy?. Dev Med Child Neurol 40 (1998) 520-527
88. National Institute of Child Health and Human Development Research Planning Workshop. Electronic fetal heart rate monitoring: research guidelines for interpretation. Am J Obstet Gynecol 177 (1997) 1385-1390
89. Nelson K.B., and Ellenberg J.H. Apgar scores as predictors of chronic neurologic disability. Pediatrics 68 (1981) 36-44
90. Cowan F., Rutherford M., Groenendaal F., et al. Origin and timing of brain lesions in term infants with neonatal encephalopathy. Lancet 361 (2003) 736-742
91. Nelson K.B., and Ellenberg J.H. Antecedents of cerebral palsy multivariate analysis of risk. N Engl J Med 315 (1986) 81-86
92. Nelson K.B., and Grether J.K. Potentially asphyxiating conditions and spastic cerebral palsy in infants of normal birth weight. Am J Obstet Gynecol 179 (1998) 507-513
93. Nelson K.B., Dambrosia J.M., Grether J.K., et al. Neonatal cytokines and coagulation factors in children with cerebral palsy. Ann Neurol 44 (1998) 665-675
94. Hull J., and Dodd K. What is birth asphyxia?. Br J Obstet Gynaecol 98 (1991) 953-955