Characterization of moderator assembly dimension for accelerator boron neutron capture therapy of brain tumors using 7Li(p,n) neutrons at proton energy of 2.5 MeV

Medical Physics

Volumn 33, Issue 6, 2006, Pages 1688-1694

  Tanaka, Kenichi ^a   Kobayashi, Tooru ^b   Bengua, Gerard ^b   Nakagawa, Yoshinobu ^c   Endo, Satoru ^a   Hoshi, Masaharu ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c National Kagawa Children's Hospital   (Japan)

Author keywords

Accelerator; BNCT

Indexed keywords

BORON; BRAIN; LITHIUM; LITHIUM COMPOUNDS; MODERATORS; PARTICLE ACCELERATORS; TUMORS;

BNCT; BORON NEUTRON CAPTURE THERAPY; BRAIN TUMORS; DOSE DISTRIBUTIONS; INNER DIAMETERS; PROTON CURRENT; PROTON ENERGY; TREATABLE PROTOCOL DEPTHS;

HEAT FLUX;

DEUTERIUM OXIDE; LITHIUM; LITHIUM FLUORIDE; POLYETHYLENE; PROTON;

ARTICLE; BRAIN TUMOR; COLLIMATOR; ELECTRIC CURRENT; ENERGY; HEAT TRANSFER; LINEAR ACCELERATOR; MEASUREMENT; NEUTRON CAPTURE THERAPY; PRIORITY JOURNAL; RADIATION DOSE; RADIATION DOSE DISTRIBUTION;

EID: 33744801982     PISSN: 00942405     EISSN: None     Source Type: Journal    
DOI: 10.1118/1.2199596     Document Type: Article

References (21)

1. C. K. Wang, T. E. Blue, and R. Gahbauer, " Neutronic study of an accelerator-based neutron irradiation facility for boron neutron capture therapy., " Nucl. Technol., 84, 93-107 (1989).
2. J. C. Yanch, R. E. Shefer, B. J. Hughey, and R. E. Klinkowstein, " Accelerator-based epithermal neutron beams for neutron capture therapy., " in Advances in Neutron Capture Therapy, edited by, A. H. Soloway,, (Plenum, New York, 1993), pp. 95-98.
3. G. L. Brownell, J. E. Kirsch, and J. Kehayias, " Accelerator production of epithermal neutrons for neutron capture therapy., " in Neutron Capture Therapy, edited by, H. Hatanaka, (Nishimura, Niigata, Japan, 1986), pp. 127-138.
4. J. W. Blue, W. K. Roberts, J. W. Bay, and S. Chou, " A plan for neutron capture therapy studies with a 2.5-MeV proton beam on Li7., " in Proceedings of the 2nd Workshop on Neutron Capture Therapy, edited by, R. G. Fairchild,, (BNL51994, Brookhaven National Laboratory, Brookhaven, NY, 1986), pp. 143-154.
5. T. Kobayashi, Y. Sakurai, K. Kanda, Y. Fujita, and K. Ono, " The remodeling and basic characteristics of the heavy water neutron irradiation facility of the Kyoto university research reactor mainly for neutron capture therapy., " Nucl. Technol. 131, 354-378 (2000).
6. S. Endo, Y. Onizuka, M. Ishikawa, M. Takada, Y. Sakurai, T. Kobayahi, K. Tanaka, M. Hoshi, and K. Shizuma, " Microdosimetry of neutron field for boron neutron capture therapy at Kyoto university reactor., " Radiat. Prot. Dosim. 110, 641-644 (2004).
7. G. Bengua, T. Kobayashi, K. Tanaka, and Y. Nakagawa, " Evaluation of the characteristics of boron-dose enhancer (BDE) materials for BNCT using near threshold Li(p,n) 7 Be7 direct neutrons., " Phys. Med. Biol. 49, 819-831 (2004).
8. C. L. Lee, X. L. Zhou, R. J. Kudchadker, F. Harmon, and Y. D. Harker, " A Monte Carlo dosimetry-based evaluation of the Li(p,n) 7 Be7 reaction near threshold for accelerator boron neutron capture therapy., " Med. Phys. 27, 192-202 (2000).
9. K. Tanaka, T. Kobayashi, Y. Sakurai, Y. Nakagawa, S. Endo, and M. Hoshi, " Dose distributions in a human head phantom for neutron capture therapy (NCT) using moderated neutrons from the 2.5 MeV proton- Li7 reaction or from fission of U235., " Phys. Med. Biol. 46, 2681-2695 (2001).
10. H. Liskien and A. Paulsen, " Neutron production cross section and energies for the reactions Li(p,n) 7 Be7 and Li(p,n) 7 Be*7., At. Data Nucl. Data Tables 15, 57-84 (1975).
11. Transport Methods Group in Los Alamos National Laboratory, TSICC Computer Code Collection MCNP4B Monte Carlo N-Particle Transport Code System, CCC-660 (1997).
12. K. Tanaka, T. Kobayashi, Y. Sakurai, Y. Nakagawa, M. Ishikawa, and M. Hoshi, " The investigation of irradiation characteristics of BNCT using the near-threshold Li(p,n) 7 Be7 direct neutrons-The application to intra-operative BNCT for malignant brain tumors., " Phys. Med. Biol. 47, 3011-3032 (2002).
13. R. S. Caswell, and J. J. Coyne, " Kerma factors for neutron energies below 30 MeV., " Radiat. Res. 83, 217-254 (1980).
14. J. H. Hubbell, " Review of photon interaction cross section data in the medical and biological context., " Phys. Med. Biol. 44, R1-R22 (1999).
15. K. Tanaka, T. Kobayashi, G. Bengua, Y. Nakagawa, S. Endo, and M. Hoshi, " TPD based evaluation of moderator characteristics for BNCT using Li(p,n) 7 neutrons at proton energy of 2.5 MeV., " Jpn. Jour. Med. Phys. 25, Sup. 3-1, 355-358 (2005).
16. T. Kobayashi, K. Tanaka, Y. Sakurai, Y. Nakagawa, S. Endo, and M. Hoshi, " Depth-dose characteristics in a water phantom for BNCT using neutrons from Li(p,n) 7 Be7 reactions at near-threshold & at 2.5 MeV and KUR-HWNIF., " in Proceedings of the 10th International Symposium on Neutron Capture Therapy for Cancer, edited by, W. Sauerwein,, (Monduzzi, Bologna, 2002), pp. 353-358.
17. Y. Nakagawa, K. Pooh, T. Kobayashi, T. Kageji, S. Uyama, A. Matsumura, and H. Kumada, " Clinical review of the Japanese experience with boron neutron capture therapy and a proposed strategy using epithermal neutron beams., " J. Neuro-Oncol. 62, 87-99 (2003).
18. R. Klinkowstein, R. Shefer, J. Yanch, W. Howard, H. Song, E. Binello, B. Blackburn, J. Daigle, S. Sears, C. Goldie, and R. Ledoux, " Operation of a high current tandem electrostatic accelerator for boron neutron capture therapy., " in Advances in Neutron Capture Therapy Volume I Medicine and Physics, edited by, A. H. Soloway,, (Plenum, New York, 1997), pp. 522-527.
19. K. Hasegawa, M. Mizumoto, N. Ito, J. Kusano, H. Oguri, Y. Touchi, and H. Murata, " Development of a high intensity RFQ at JAERI., " J. Nucl. Sci. Technol. 34, 622-627 (1997).
20. B. Bayanov, V. Belov, E. Bender, M. Bokhovko, G. Dimov, V. Kononov, O. Kononov, N. Kuksanov, V. Palchikov, V. Pivovarov, R. Salimov, G. Silvestrov, A. Skirinsky, N. Soloviov, and S. Taskaev, " Accelerator-based neutron source for the neutron-capture and fast neutron therapy at hospital., " Nucl. Instrum. Methods Phys. Res. A A413, 397-426 (1998).
21. K. Tanaka, T. Kobayashi, G. Bengua, Y. Nakagawa, S. Endo, and M. Hoshi, " Characteristics of BDE dependent on dose protocol and B10 concentration for BNCT using near-threshold Li(p,n) 7 Be7 direct neutrons., " Phys. Med. Biol. 50, 167-177 (2005).