RACK-1 expression and cytokine production in leukocytes obtained from AD patients

Aging Clinical and Experimental Research

Volumn 18, Issue 2, 2006, Pages 153-157

  Racchi, Marco ^a   Sinforiani, Elena ^b   Govoni, Stefano ^a   Marinovich, Marina ^c   Galli, Corrado L ^c   Corsini, Emanuela ^c,d  

^a UNIVERSITY OF PAVIA   (Italy)

^b C MONDINO NATIONAL NEUROLOGICAL INSTITUTE   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

^d Laboratory of Toxicology   (Italy)

Author keywords

Aging; Cytokine; DHEA; Immunosenescence; Protein kinase C

Indexed keywords

BRAIN PROTEIN; INTERLEUKIN 10; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; PRASTERONE; PROTEIN RACK 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADULT; AGED; AGING; ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DOWNSTREAM PROCESSING; ENZYME IMMUNOASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; IMMUNE DYSREGULATION; IN VITRO STUDY; LEUKOCYTE; MAJOR CLINICAL STUDY; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

EID: 33744801703     PISSN: 15940667     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03327432     Document Type: Article

References (9)

1. Bruunsgaard H, Pedersen AN, Pedersen BK. Aging and proinflammatory cytokines. Curr Opin Hematol 2001; 8: 131-6.
2. Lio D, Scola L, Crivello A, et al. Inflammation, genetics, and longevity: further studies on the protective effects in men of IL-10 - 1082 promoter SNP and its interaction with TNF-α - 308 promoter SNP. J Med Genet 2003; 40: 296-9.
3. Corsini E, Battaini F, Lucchi L, et al. A defective protein kinase C anchoring system underlying age-associated impairment in TNF-α production in rat macrophages. J Immunol 1999; 163: 3468-73.
4. Corsini E, Racchi M, Sinforiani E, et al. Age-related decline in RACK-1 expression in human leukocytes is correlated to plasma levels of dehydroepiandrosterone. J Leukocyte Biol 2005; 77: 247-56.
5. Corsini E, Lucchi L, Meroni M, et al. In vivo dehydroepiandrosterone restores age-associated defects in protein kinase C signal transduction pathway and related functional responses. J Immunol 2002; 168: 1753-8.
6. Viviani B, Bartesaghi S, Corsini E, Galli CL, Marinovich M. Cytokines role in neurodegenerative events. Toxicol Lett 2004; 149: 85-9.
7. Hanada T, Yoshimura A. Regulation of cytokine signaling and inflammation. Cytokine Growth Factor Rev 2002; 13: 413-21.
8. Bruunsgaard H, Pedersen AN, Schroll M, Skinhoi P, Pedersen BK. Impaired production of proinflammatory cytokines in response to lipopolysaccharide (LPS) stimulation in elderly human. Clin Exp Immunol 1999; 118: 235-41.
9. Gleckman R, Hibert D. Afebrile bacteremia. A phenomenon in geriatric patients. JAMA 1982; 248: 1478-81.