Vobasinyl-iboga bisindole alkaloids, potent acetylcholinesterase inhibitors from Tabernaemontana divaricata root

Journal of Pharmacy and Pharmacology

Volumn 58, Issue 6, 2006, Pages 847-852

  Ingkaninan, Kornkanok ^a   Changwijit, Kanokwan ^a   Suwanborirux, Khanit ^b  

^a NARESUAN UNIVERSITY   (Thailand)

^b CHULALONGKORN UNIVERSITY   (Thailand)

Author keywords

[No Author keywords available]

Indexed keywords

19,20 DIHYDROERVAHANINE A; 19,20 DIHYDROTABERNAMINE; ALKALOID; CHOLINESTERASE INHIBITOR; CONDURINE; GALANTAMINE; PLANT EXTRACT; TABERNAELEGANTINE A; UNCLASSIFIED DRUG;

ARTICLE; BIOASSAY; COLORIMETRY; CONTROLLED STUDY; DRUG INHIBITION; FRACTIONATION; MEDICINAL PLANT; NONHUMAN; TABERNAEMONTANA;

ALKALOIDS; CHOLINESTERASE INHIBITORS; MAGNETIC RESONANCE SPECTROSCOPY; PLANT ROOTS; TABERNAEMONTANA;

EID: 33744795962     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.58.6.0015     Document Type: Article

References (14)

1. Andrade, M. T., Lima, J. A., Pinto, A. C., Rezende, C. M., Carvalho, M. P., Epifanio, R. A. (2005) Indole alkaloids from Tabernaemontana australis (Muell. Arg) Mier that inhibit acetylcholinesterase enzyme. Bioorg. Med. Chem. 13: 4092-4095
2. Cordell, G. A., Saxton, J. E., Shamma M., Smith, G. F. (1989) Dictionary of alkaloids. Chapman and Hall, London
3. Ellman, G. L., Lourtney, D. K., Andres, V., Gmelin, G. (1961) A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem. Pharmacol. 7: 88-95
4. Henriques, A. T., Melo, A. A., Moreno, P. R., Ene, L. L., Henriques, J. A., Schapoval, E. E. (1996) Ervatamia coronaria: chemical constituents and some pharmacological activities. J. Ethnopharmacol. 50: 19-25
5. Ingkaninan, K., Temkitthawon, P., Chuenchom, K., Yuyaem, T., Thongnoi, W. (2003) Screening for acetylcholinesterase inhibitory activity in plants used in Thai traditional rejuvenating and neurotonic remedies. J. Ethonopharmacol. 89: 261-264
6. Johnson, N., Davis, T., Bosanquet, N. (2000) The epidemic of Alzheimer's disease: how can we manage the costs? Pharmacoeconomics 18: 215-223
7. Kam, T., Sim, K. (2003) Conodurine, conoduramine, and ervahanine derivatives from Tabernaemontana corymbosa. Phytochemistry 63: 625-629
8. Kuo, Y. C., Sun, C. M., Tsai, W. J., Ou, J. C., Chen, W. P., Lin, C. Y. (1999) Blocking of cell proliferation, cytokines production and gene expression following administration of Chinese herbs in the human mesangial cells. Life Sd. 64: 2089-2099
9. Leeuwenberg, A. J. M. (1991) Tabernaemontana: the old world species. Royal Botanic Garden, Kew, London
10. Melo, A. A., Querol, C. B., Henriques, A. T., Henriques, J. A. (1986) Cytostatic, cytotoxic and mutagenic effects of voacristine, an indole alkaloid in wild-type and repair-deficient yeasts. Mutat. Res. 171: 17-24
11. Mroue, M. A., Euler, K. L., Ghuman, M. A., Alam, M. (1996) Indole alkaloids of Haplophyton crooksii. J. Nat. Prod. 59: 890-893
12. Scarpini, E., Scheltens, P., Feldman, H. (2003) Treatment of Alzheimer's disease: current status and new perspectives. Lancet Neur. 2: 539-547
13. Taesotikul, T., Panthong, A., Kanjanapothi, D., Verpoorte, R., Scheffer, J. J. (1989) Hippocratic screening of ethanolic extracts from two Tabernaemontana species. J. Ethnopharmacol. 27: 99-106
14. van Beek, T. A., Verpoorte, R., Baerheim Svendsen, A., Leeuwenberg, A. J. M., Bisset, N. G. (1984) Tabernaemontana L. (Apocynaceae): a review of its taxonomy, phytochemistry, ethnobotany and pharmacology. J. Ethnophamacol. 10: 1-156