Open channels block of Kv3.1 currents by genistein, a tyrosine kinase inhibitor

Korean Journal of Physiology and Pharmacology

Volumn 10, Issue 2, 2006, Pages 71-77

  Choi, Bok Hee ^a   Park, Ji Hyun ^b   Hahn, Sang June ^b  

^a Chonbuk National University   (South Korea)

^b The Catholic University of Korea   (South Korea)

Author keywords

Genistein; Kv3.1; Open channel block; Tyrosine kinase inhibitor

Indexed keywords

GENISTEIN; POTASSIUM CHANNEL; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR;

ANIMAL CELL; ARTICLE; BINDING KINETICS; CHANNEL GATING; CHO CELL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DEPOLARIZATION; ELECTRIC POTENTIAL; ENZYME INHIBITION; IC 50; NONHUMAN; PATCH CLAMP; POTASSIUM CURRENT; PROTEIN EXPRESSION; RAT; REPOLARIZATION; STEADY STATE; TAIL; TIME; WHOLE CELL;

EID: 33744792046     PISSN: 12264512     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Akiyama T, Ishida J, Nakagawa S, Ogawara H, Watanabe S, Itoh N, Shibuya M, Fukami Y. Genistein, a specific inhibitor of tyrosine-specific protein kinases. J Biol Chem 262: 5592-5595, 1987.
2. Aniksztejn L, Catarsi S, Drapeau P. Channel modulation by tyrosine phosphorylation in an identified leech neuron. J Physiol 498 (Pt 1): 135-142, 1997.
3. Chang KL, Kung ML, Chow NH, Su SJ. Genistein arrests hepatoma cells at G2/M phase: involvement of ATM activation and upregulation of p21waf1/ cip1 and Wee1. Biochem Pharmacol 67: 717-726, 2004.
4. Chiang CE, Chen SA, Chang MS, Lin CI, Luk HN. Genistein directly inhibits L-type calcium currents but potentiates cAMP-dependent chloride currents in cardiomyocytes. Biochem Biophys Bee Common 223: 598-603, 1996.
5. Choi BH, Choi JS, Jeong SW, Hahn SJ, Yoon SH, Jo YH, Kim MS. Direct block by bisindolylmaleimide of rat Kv1.5 expressed in Chinese hamster ovary cells. J Pharmacol Exp Ther 293: 634-640, 2000.
6. Choi BH, Choi JS, Yoon SH, Rhie DJ, Min DS, Jo YH, Kim MS, Hahn SJ. Effects of norfluoxetine, the major metabolite of fluoxetine, on the cloned neuronal potassium channel Kv3.1. Neuropharmacology 41: 443-453, 2001.
7. Delpon E, Valenzuela C, Gay P, Franqueza L, Snyders DJ, Tamargo J. Block of human cardiac Kv1.5 channels by loratadine: voltage-, time- and use-dependent block at concentrations above therapeutic levels. Cardiovasc Res 35: 341-350, 1997.
8. Dubois JM, Rouzaire-Dubois B. Role of potassium channels in mitogenesis. Prog Biophys Mol Biol 59: 1-21, 1993.
9. Fadool DA, Holmes TC, Berman K, Dagan D, Levitan IB. Tyrosine phosphorylation modulates current amplitude and kinetics of a neuronal voltage-gated potassium channel. J Neurophysiol 78: 1563-1573, 1997.
10. + channel in T cells. J Biol Chem 267: 2099-20971, 1992.
11. Holmes TC, Fadool DA, Levitan IB. Tyrosine phosphorylation of the Kv1.3 potassium channel. J Neurosci 16: 1581-1590, 1996.
12. Huang XY, Morielli AD, Peralta EG. Tyrosine kinase-dependent suppression of a potassium channel by the G protein-coupled m1 muscarinic acetylcholine receptor. Cell 75: 1145-1156, 1993.
13. Jonas EA, Kaczmarek LK. Regulation of potassium channels by protein kinases. Curr Opin Neurobiol 6: 318-323, 1996.
14. Jonas EA, Knox RJ, Kaczmarek LK, Schwartz JH, Solomon DH. Insulin receptor in Aplysia neurons: characterization, molecular cloning, and modulation of ion currents. J Neurosci 16: 1645-1658, 1996.
15. Kaczmarek LK. Voltage-dependent potassium channels: minK and Shaker families. New Biol 3: 315-323, 1991.
16. Kanemasa T, Gan L, Perney TM, Wang LY, Kaczmarek LK. Electrophysiological and pharmacological characterization of a mammalian Shaw channel expressed in NIH 3T3 fibroblasts. J Neurophysiol 74: 207-217, 1995.
17. Levitan IB. Modulation of ion channels by protein phosphorylation and dephosphorylation. Annu Rev Physiol 56: 193-212, 1994.
18. + channel diversity in the mammalian central nervous system. Proc Natl Acad Sci USA 88: 3932-3936, 1991.
19. Macica CM, Kaczmarek LK. Casein kinase 2 determines the voltage dependence of the Kv3.1 channel in auditory neurons and transfected cells. J Neurosci 21: 1160-1168, 2001.
20. + channel gating in mouse Schwann cells. J Physiol 519: 373-384, 1999.
21. Perney TM, Marshall J, Martin KA, Hockfield S, Kaczmarek LK. Expression of the mRNAs for the Kv3.1 potassium channel gene in the adult and developing rat brain. J Neurophysiol 68: 756-766, 1992.
22. Siegelbaum SA. Channel regulation. Ion channel control by tyrosine phosphorylation. Curr Biol 4: 242-245, 1994.
23. + currents by tyrosine kinase inhibitors genistein and ST 638. Circ Res 76: 310-316, 1995.
24. Snyders DJ, Yeola SW. Determinants of antiarrhythmic drug action. Electrostatic and hydrophobic components of block of the human cardiac hKv1.5 channel. Circ Res 77: 575-583, 1995.
25. Su SJ, Chow NH, Kung ML, Hung TC, Chang KL. Effects of soy isoflavones on apoptosis induction and G2-M arrest in human hepatoma cells involvement of caspase-3 activation, Bcl-2 and Bcl-XL downregulation, and Cdc2 kinase activity. Nutr Cancer 45: 113-123, 2003.
26. Su SJ, Yeh TM, Chuang WJ, Ho CL, Chang KL, Cheng HL, Liu HS, Cheng HL, Hsu PY, Chow NH. The novel targets for antiangiogenesis of genistein on human cancer cells. Biochem Pharmacol 69: 307-318, 2005.
27. + channel in T lymphocytes upon Fas stimulation. J Biol Chem 271: 20465-20469, 1996.
28. Valenzuela C, Delpon E, Franqueza L, Gay P, Perez O, Tamargo J, Snyders DJ. Class III antiarrhythmic effects of zatebradine. Time-, state-, use-, and voltage-dependent block of hKv1.5 channels. Circulation 94: 562-570, 1996.
29. Wang LY, Gan L, Forsythe ID, Kaczmarek LK. Contribution of the Kv3.1 potassium channel to high-frequency firing in mouse auditory neurones. J Physiol 509: 183-194, 1998.
30. + channels in regulating tumour cell proliferation and apoptosis. Pflugers Arch 448: 274-286, 2004.
31. Washizuka T, Horie M, Obayashi K, Sasayama S. Genistein inhibits slow component delayed-rectifier K currents via a tyrosine kinase-independent pathway. J Mol Cell Cardiol 30: 2577-2590, 1998.
32. + channels in the rat central nervous system. J Neurosci 14: 949-972, 1994.
33. Wijetunge S, Aalkjaer C, Schachter M, Hughes AD. Tyrosine kinase inhibitors block calcium channel currents in vascular smooth muscle cells. Biochem Biophys Res Commun 189: 1620-1623, 1992.
34. Yu Z, Li W, Liu F. Inhibition of proliferation and induction of apoptosis by genistein in colon cancer HT-29 cells. Cancer Lett 215: 159-166, 2004.