Effects of human pharmaceuticals on aquatic life: Next steps

Environmental Science and Technology

Volumn 40, Issue 11, 2006, Pages 3456-3462

  Cunningham, Virginia L ^a   Buzby, Mary ^b   Hutchinson, Thomas ^c   Mastrocco, Frank ^d   Parke, Neil ^e   Roden, Nicholas ^f  

^a GLAXOSMITHKLINE   (United Kingdom)

^b MERCK RESEARCH LABORATORIES   (United States)

^c ASTRAZENECA   (United Kingdom)

^d PFIZER INC   (United States)

^e ELI LILLY AND COMPANY   (United States)

^f Schering Plough Corporation   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AQUATIC LIFE; CHRONIC EFFECTS; EXPERIMENTAL TESTS; WATER-SHED MODEL;

DRUG PRODUCTS; ENVIRONMENTAL ENGINEERING; ENVIRONMENTAL IMPACT; MATHEMATICAL MODELS; OCEAN HABITATS; TOXIC MATERIALS;

WATER POLLUTION;

DRUG PRODUCTS; ENVIRONMENTAL ENGINEERING; ENVIRONMENTAL IMPACT; MATHEMATICAL MODELS; OCEAN HABITATS; TOXIC MATERIALS; WATER POLLUTION;

AQUATIC ENVIRONMENT; DRUG; ENVIRONMENTAL IMPACT ASSESSMENT; WATER QUALITY;

AQUATIC ENVIRONMENT; EFFLUENT; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL RELEASE; HEALTH HAZARD; POLLUTION; REVIEW; RISK ASSESSMENT; WASTE COMPONENT REMOVAL; WATERSHED;

ANIMALS; DAPHNIA; ECOSYSTEM; ENVIRONMENTAL MONITORING; HUMANS; PHARMACEUTICAL PREPARATIONS; RISK ASSESSMENT; SEWAGE; WATER POLLUTANTS, CHEMICAL; WATER POLLUTION, CHEMICAL;

EID: 33744789363     PISSN: 0013936X     EISSN: None     Source Type: Journal    
DOI: 10.1021/es063017b     Document Type: Review

References (25)

1. Ternes, T. A. Occurrence of Drugs in German Sewage Treatment Plants and Rivers. Water Res. 1998, 32, 3245-3260.
2. Halling-Sorensen, B.; et al. Occurrence, Fate and Effects of Pharmaceutical Substances in the Environment-A Review. Chemosphere 1998, 36, 357-393.
3. Kolpin, D. W.; et al. Pharmaceuticals, Hormones, and Other Organic Wastewater Contaminants in U.S. Streams, 1999-2000: A National Reconnaissance. Environ. Sci. Technol. 2002, 36, 1202-1211.
4. Kümmerer, K., Ed. Pharmaceuticals in the Environment, 2nd ed.; Springer-Verlag: New York, 2004.
5. Williams, R. T., Ed. Human Pharmaceuticals: Assessing the Impacts on Aquatic Ecosystems; SETAC Press: Pensacola, FL, 2005.
6. Boxall, A. B. A.; et al. Are Veterinary Medicines Causing Environmental Risks? Environ. Sci. Technol. 2003, 37, 287A-294A.
7. Velagaleti, R.; et al. Impact of Current Good Manufacturing Practices and Emission Regulations and Guidances on the Discharge of Pharmaceutical Chemicals into the Environment from Manufacturing, Use and Disposal. Environ. Health Perspect. 2002, 110, 213-220.
8. Stackelberg, P. E.; et al. Persistence of Pharmaceutical Compounds and Other Organic Wastewater Contaminants in a Conventional Drinking-Water-Treatment Plant. Sci. Total Environ. 2004, 329, 99-113.
9. Jones, O. A.; Lester, J. N.; Voulvoulis, N. Pharmaceuticals: A Threat To Drinking Water? Trends Biotechnol. 2005, 23, 163-167.
10. Schwab, B. W.; et al. Human Pharmaceuticals in U.S. Surface Water: A Human Health Risk Assessment. Regul. Toxicol. Pharmacol 2005, 42, 296-312.
11. Guidance for Industry-Environmental Assessment of Human Drug and Biologics Applications, CMC6 Revision 1; FDA Center for Drug Evaluation and Research: Rockville, MD, 1998; www.fda.gov/cber/gdlns/environ.pdf.
12. Guideline on the Environmental Risk Assessment of Medicinal Products for Human Use, CMCP/SWP/4447/draft; European Agency for the Evaluation of Medicinal Products: London, 2005; www.emea.eu.int/pdfs/human/ swp/444700en.pdf.
13. Anderson, P. D.; et al. Screening Analysis of Human Pharmaceutical Compounds in U.S. Surface Waters. Environ. Sci. Technol. 2004, 38, 838-849.
14. Feijtel, T. C. J.; et al. Development of a Geography-Referenced Regional Exposure Assessment Tool for European Rivers-GREAT-ER. Contribution to GREAT-ER#1. Chemosphere 1997, 34, 2351-2373.
15. Schowanek, D.; Webb, S. Exposure Simulation for Pharmaceuticals in European Surface Waters with GREATER. Toxicol. Lett. 2002, 131, 39-50.
16. Cowan, C. E.; et al. An Improved Model for Predicting the Fate of Consumer Product Chemicals in Wastewater Treatment Plants. Water Res. 1993, 27, 561-573.
17. Struijs, J.; Stoltenkamp, J.; van de Meent, D. A Spreadsheet-Based Box Model to Predict the Fate of Xenobiotics in a Municipal Wastewater Treatment Plant. Water Res. 1991, 25, 891-900.
18. Fent, K.; Weston, A. A.; Caminada, D. Ecotoxicology of Human Pharmaceuticals. Aquat. Toxicol. 2006, 76, 122-159.
19. Versteeg, D. J.; et al. Environmental Exposure Modeling and Monitoring of Human Pharmaceuticals in the Environment. In Human Pharmaceuticals: Assessing the Impacts on Aquatic Ecosystems; Williams, R. T., Ed.; SETAC Press: Pensacola, FL, 2005; pp 71-110.
20. Hutchinson, T. H.; et al. Development of Fish Tests for Endocrine Disruptors. Pure Appl. Chem. 2003, 75, 2343-2353.
21. Ankley, G. T.; et al. A Framework for Assessing the Hazard of Pharmaceutical Materials to Aquatic Species. In Human Pharmaceuticals: Assessing the Impacts on Aquatic Ecosystems; Williams, R. T., Ed.; SETAC Press: Pensacola, FL, 2005; pp 183-237.
22. Verhaar, H. J. M.; van Leeuwen, C. J.; Hermens, J. L. M. Classifying Environmental Pollutants. 1: Structure-Activity Relationships for Prediction of Aquatic Toxicity. Chemosphere 1992, 25, 471-491.
23. Huggett, D. B.; et al. Theoretical Model for Utilizing Mammalian Pharmacology and Safety Data to Prioritize Potential Impacts of Human Pharmaceuticals to Fish. Hum. Ecol. Risk Assess. 2003, 9, 1789-1799.
24. Huggett, D. B.; et al. The Role of Mammalian Data in Determining Pharmaceutical Responses in Aquatic Species. In Human Pharmaceuticals: Assessing the Impacts on Aquatic Ecosystems; Williams, R. T., Ed.; SETAC Press: Pensacola, FL, 2005; pp 149-181.
25. Hutchinson, T. H.; et al. Current Research Needs to Improve the Science Supporting the Environmental Stewardship of Human Pharmaceuticals. In Human Pharmaceuticals: Assessing the Impacts on Aquatic Ecosystems; Williams, R. T., Ed.; SETAC Press: Pensacola, FL, 2005; pp 303-311.